Zobrazeno 1 - 10
of 180
pro vyhledávání: '"L K, Wong"'
Autor:
Jacquelyn R. McDonald, Bryan C. Jensen, Aakash Sur, Iris L. K. Wong, Stephen M. Beverley, Peter J. Myler
Publikováno v:
Pathogens, Vol 11, Iss 8, p 930 (2022)
Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding g
Externí odkaz:
https://doaj.org/article/ec7b0b0f4a8e43e2ba9b9ac9e585c993
Autor:
Kin-Fai Chan, Ning Sun, Siu-Cheong Yan, Iris L. K. Wong, Hok-Kiu Lui, Kwan-Choi Cheung, Jian Yuan, Fung-Yi Chan, Zhiwei Zheng, Edward W. C. Chan, Sheng Chen, Yun-Chung Leung, Tak Hang Chan, Kwok-Yin Wong
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 7281-7292 (2017)
Externí odkaz:
https://doaj.org/article/fe43b9ffa0e742c497654357194e1226
Autor:
Wenqin Sun, Iris L. K. Wong, Helen Ka-Wai Law, Xiaochun Su, Terry C. F. Chan, Gege Sun, Xinqing Yang, Xingkai Wang, Tak Hang Chan, Shengbiao Wan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4377
Volume 24
Issue 5
Pages: 4377
The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR) and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as epigallocatechin gallate (EGCG), have low P-gp-modulating activity, with an EC50 over 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f66d38295de12b95ead2a18b4c76ef
Autor:
M. D. Ibrahim, S. N. A. Amran, Y. S. Yunos, M. R. A. Rahman, M. Z. Mohtar, L. K. Wong, A. Zulkharnain
Publikováno v:
Applied Bionics and Biomechanics, Vol 2018 (2018)
The skin of a fast swimming shark reveals riblet structures that help reduce the shark’s skin friction drag, enhancing its efficiency and speed while moving in the water. Inspired by the structure of the shark skin denticles, our team has carried o
Externí odkaz:
https://doaj.org/article/e8a165edbb75453eb21207ded943c79f
Autor:
Larry M.C. Chow, Chin-Fung Chan, Man Chun Law, Xuezhen Zhu, Tsz Cheung Chong, Zhen Liu, Tsun Sing Chow, Jiahua Cui, Kin-Fai Chan, Tak Hang Chan, Iris L. K. Wong
Publikováno v:
Journal of Medicinal Chemistry. 64:14311-14331
We synthesize various substituted triazole-containing flavonoids and identify potent, nontoxic, and highly selective BCRP inhibitors. Ac18Az8, Ac32Az19, and Ac36Az9 possess m-methoxycarbonylbenzyloxy substitution at C-3 of the flavone moiety and subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e263f6d662e83c7fb1095f6382fe523f
https://doi.org/10.1021/acs.jmedchem.1c00779
https://doi.org/10.1021/acs.jmedchem.1c00779
Autor:
Tsz Cheung, Chong, Iris L K, Wong, Jiahua, Cui, Man Chun, Law, Xuezhen, Zhu, Xuesen, Hu, Jason W Y, Kan, Clare S W, Yan, Tak Hang, Chan, Larry M C, Chow
Publikováno v:
International journal of molecular sciences. 23(21)
Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37c1ff8947a2264dd2d4dfa61a2d7324
https://pubmed.ncbi.nlm.nih.gov/36362047
https://pubmed.ncbi.nlm.nih.gov/36362047
Publikováno v:
Marine Drugs, Vol 12, Iss 10, Pp 5209-5221 (2014)
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relat
Externí odkaz:
https://doaj.org/article/6a8ebc29db2b475295478b6bbec1e5e2
Autor:
Teng Chen, Xiaochun Su, Tak Hang Chan, Wenqin Sun, Peng Li, Tsun Sing Chow, Larry M.C. Chow, Iris L. K. Wong, Kit Ying Choy, Xinqing Yang, Yunjiao He
Publikováno v:
Molecular Cancer Therapeutics. 20:76-84
Staphylococcal nuclease domain-containing protein 1 (SND1) is a multifunctional oncoprotein overexpressed in breast cancer. Binding of metadherin (MTDH) to SND1 results in the stabilization of SND1 and is important in the initiation and progression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68c0524d4e66e32addbca589c8a5fbf
https://doi.org/10.1158/1535-7163.mct-20-0130
https://doi.org/10.1158/1535-7163.mct-20-0130
Publikováno v:
Case Reports in Infectious Diseases, Vol 2015 (2015)
Tuberculosis is an opportunistic infection with protean clinical manifestations. We describe a case of Ruxolitinib induced miliary tuberculosis presenting as a neck lump. A 78-year-old female presented with a two-month history of right-sided neck lum
Externí odkaz:
https://doaj.org/article/88c2a7a9925a45449a6051a47da87842
Autor:
Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15299
Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC50 = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297ab9288971f1e08816d2d7236731c5
https://doi.org/10.3390/ijms232315299
https://doi.org/10.3390/ijms232315299