Výsledky vyhledávání

Pubertal Exposure to High Fat Diet Causes Mouse Strain-dependent Alterations in Mammary Gland Development and Estrogen Responsiveness

Autor: Sandra Z. Haslam, Yong Zhao, L K Olson, Ying S. Tan, Mark D. Aupperlee

Publikováno v: International journal of obesity (2005)

Objective Increased adolescent obesity rates in the United States are a significant public health concern. Obesity or increased adiposity during puberty in girls, an important period of breast development and a window of exposure sensitivity, may inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253638d03783e89ba5a97a06803ec2c9
http://europepmc.org/articles/PMC2923244

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Natural Electrophoresis of Norepinephrine and Ascorbic Acid

Autor: Patrick F. Dillon, Patrick R. Sears, Robert Root-Bernstein, L. K. Olson

Publikováno v: Biophysical Journal. 79:370-376

The electric field produced by cell membranes, extending only a few nanometers, is 1000 times stronger than the electric fields required to produce dissociation of molecular complexes. Using the complex formed by norepinephrine (NE) and ascorbic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4e51a313e1bf1c49893a3193c8d5b2
https://doi.org/10.1016/s0006-3495(00)76298-9

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[Untitled]

Autor: Elizabeth N. Kaytor, J. Qian, L K Olson, Howard C. Towle

Publikováno v: Molecular and Cellular Biochemistry. 210:13-21

Transcription of the L-type pyruvate kinase (L-PK) and S14 genes is induced in hepatocytes in response to increased glucose metabolism. The regulatory sequences of these genes responsible for induction by glucose have been mapped to related E-box con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3f38c65a211327741174174c43eacc4
https://doi.org/10.1023/a:1007006429041

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Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic β-cells

Autor: Howard C. Towle, L K Olson, J. Qian, Elizabeth N. Kaytor

Publikováno v: Biochemical Journal. 341:315-322

The homeobox gene Pdx-1 plays a key role in the development of the pancreas. In the adult, however, expression of the Pdx-1 gene is restricted to pancreatic beta-cells and endocrine cells of duodenal epithelium. Recently, the transcription factor, up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::daf6b473aca26f33ffe6d14ec9ac3c7f
https://doi.org/10.1042/bj3410315

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Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator

Autor: Vincent Poitout, L. K. Olson, R. P. Robertson

Publikováno v: Journal of Clinical Investigation. 97:1041-1046

We have shown previously that chronic exposure of HIT-T15 cells to supraphysiologic glucose concentrations causes decreased insulin gene transcription and decreased binding activities of two beta-cell specific transcription factors, STF-1 and the RIP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12629f1903b45d88ab35df3fa5281c1f
https://doi.org/10.1172/jci118496

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Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

Autor: Richard A. Stein, L. K. Olson, Christopher V.E. Wright, Arun Sharma, R P Rodertson, Mina Peshavaria, Howard C. Towle

Publikováno v: Proceedings of the National Academy of Sciences. 92:9127-9131

Chronic exposure of HIT-T15 beta cells to elevated glucose concentrations leads to decreased insulin gene transcription. The reduction in expression is accompanied by diminished binding of a glucose-sensitive transcription factor (termed GSTF) that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf1793359f076bbf2319a77b6305f55
https://doi.org/10.1073/pnas.92.20.9127

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Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein

Autor: Howard C. Towle, L K Olson, J. B. Redmon, R. P. Robertson

Publikováno v: Scopus-Elsevier

Chronically culturing HIT-T15 cells in media containing high glucose concentrations leads to decreased insulin mRNA levels, insulin content, and insulin secretion. These changes can be prevented by culturing the cells in media containing lower glucos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4c50d98b99777b745ca9642866ae69
https://doi.org/10.1172/jci116596

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