Randomised, open-label, multicentric phase III trial to evaluate the safety and efficacy of palbociclib in combination with endocrine therapy, guided by ESR1 mutation monitoring in oestrogen receptor-positive, HER2-negative metastatic breast cancer patients: study design of PADA-1

Autor: C Cheneau, S Barthier, J Lemonnier, Fabrice Andre, C Dubot, L Teixeira, A Escande, T De La Motte Rouge, T Petit, L Arnould, Laurent Arnould, Suzette Delaloge, Jerome Lemonnier, A Marti, L Stefani, F Berger, C Levy, P Barthelemy, S Nguyen, M Gardner, A Lortholary, François-Clément Bidard, J Plaza, L Joly, Thibault de la Motte Rouge, F Andre, I Bièche, C Alleaume, R Sabatier, B Lucas, Ivan Bieche, O Derbel, L Venat-Bouvet, F Del Piano, Florian Clatot, Anne-Claire Hardy-Bessard, Frédérique Berger, Margaux Marce, Thomas Bachelot, Anne Pradines, Jean-Luc Canon, Sandrine Marques, M Achille, H Ammarguellat, O Arsene, T Bachelot, C Bernard-Marty, F-C Bidard, N Bonichon-Lamichhane, N Bonnin, R Bouaita, A Boudrant, V-A Brunel, C Chakiba, F Clatot, F Dalenc, A De Gramont, L Deiana, C Delbaldo, V Delecroix, H Desclos, V D'Hondt, N Dohollou, J-M Ferrero, C Foa, J-S Frenel, C Garnier Tixidre, D Genet, O Gisserot, M Gozy, C Greilsamer, J Grenier, F Guinet, A-C Hardy-Bessard, J-P Jacquin, E Lachaier, S Ladoire, A-P Laurenty, R Le Scodan, N Leduc, E Legouffe, C Levache, F Lorchel, N Marques, J Medioni, A Melis, D Mille, D Mollon, L Moreau, I Moullet, M-A Mouret-Reynier, A Najem, H Orfeuvre, J-F Paitel, B Pistilli, C Riedl, P Soulie, D Spaeth, F Trouboul, C Valmar, H Vegas, A Zannetti, FC Bidard, S Delaloge, A Pradines, JL Canon, S Marques

Publikováno v: BMJ Open, Vol 12, Iss 3 (2022)

Introduction The combination of a CDK4/6 inhibitor with an aromatase inhibitor (AI) has recently become the gold standard for AI-sensitive first line treatment of oestrogen receptor-positive (ER+) HER2-negative (HER2−) advanced breast cancer. Howev

Externí odkaz: https://doaj.org/article/8faf6bbc845f4ceeb90674dd08e198da

Improved calibration procedures for the EM27/SUN spectrometers of the COllaborative Carbon Column Observing Network (COCCON)

Autor: C. Alberti, F. Hase, M. Frey, D. Dubravica, T. Blumenstock, A. Dehn, P. Castracane, G. Surawicz, R. Harig, B. C. Baier, C. Bès, J. Bi, H. Boesch, A. Butz, Z. Cai, J. Chen, S. M. Crowell, N. M. Deutscher, D. Ene, J. E. Franklin, O. García, D. Griffith, B. Grouiez, M. Grutter, A. Hamdouni, S. Houweling, N. Humpage, N. Jacobs, S. Jeong, L. Joly, N. B. Jones, D. Jouglet, R. Kivi, R. Kleinschek, M. Lopez, D. J. Medeiros, I. Morino, N. Mostafavipak, A. Müller, H. Ohyama, P. I. Palmer, M. Pathakoti, D. F. Pollard, U. Raffalski, M. Ramonet, R. Ramsay, M. K. Sha, K. Shiomi, W. Simpson, W. Stremme, Y. Sun, H. Tanimoto, Y. Té, G. M. Tsidu, V. A. Velazco, F. Vogel, M. Watanabe, C. Wei, D. Wunch, M. Yamasoe, L. Zhang, J. Orphal

Publikováno v: Atmospheric Measurement Techniques, Vol 15, Pp 2433-2463 (2022)

In this study, an extension on the previously reported status of the COllaborative Carbon Column Observing Network's (COCCON) calibration procedures incorporating refined methods is presented. COCCON is a global network of portable Bruker EM27/SUN FT

Externí odkaz: https://doaj.org/article/871c53e1d30a44a3b942f53bfbf2d7e9

The development of the Atmospheric Measurements by Ultra-Light Spectrometer (AMULSE) greenhouse gas profiling system and application for satellite retrieval validation

Autor: L. Joly, O. Coopmann, V. Guidard, T. Decarpenterie, N. Dumelié, J. Cousin, J. Burgalat, N. Chauvin, G. Albora, R. Maamary, Z. Miftah El Khair, D. Tzanos, J. Barrié, É. Moulin, P. Aressy, A. Belleudy

Publikováno v: Atmospheric Measurement Techniques, Vol 13, Pp 3099-3118 (2020)

We report in this paper the development of an embedded ultralight spectrometer ( kg) based on tuneable diode laser absorption spectroscopy (with a sampling rate of 24 Hz) in the mid-infrared spectral region. This instrument is dedicated to in sit

Externí odkaz: https://doaj.org/article/9f7cdcc4324844fbb0157699ced2c695

Genome-Wide Characterization of the MLO Gene Family in Cannabis sativa Reveals Two Genes as Strong Candidates for Powdery Mildew Susceptibility

Autor: Noémi Pépin, Francois Olivier Hebert, David L. Joly

Publikováno v: Frontiers in Plant Science, Vol 12 (2021)

Cannabis sativa is increasingly being grown around the world for medicinal, industrial, and recreational purposes. As in all cultivated plants, cannabis is exposed to a wide range of pathogens, including powdery mildew (PM). This fungal disease stres

Externí odkaz: https://doaj.org/article/d9e2ea98b46240b2820b51c890f351e1

Expression of Putative Defense Responses in Cannabis Primed by Pseudomonas and/or Bacillus Strains and Infected by Botrytis cinerea

Autor: Carole Balthazar, Gabrielle Cantin, Amy Novinscak, David L. Joly, Martin Filion

Publikováno v: Frontiers in Plant Science, Vol 11 (2020)

Cannabis (Cannabis sativa L.) offers many industrial, agricultural, and medicinal applications, but is commonly threatened by the gray mold disease caused by the fungus Botrytis cinerea. With few effective control measures currently available, the us

Externí odkaz: https://doaj.org/article/08405a63248a4c8b950ad17e91a26a71