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Autor:
Davies SS; Vanderbilt University, United States. Electronic address: sean.davies@vanderbilt.edu., Fessel JP; NIH/NCATS, United States., Milne GL; Vanderbilt University Medical Center, United States., Moore K; University College of London, United Kingdom., Yin H; City University of Hong Kong, Hong Kong.
Publikováno v:
Free radical biology & medicine [Free Radic Biol Med] 2023 Jul 13; Vol. 207, pp. 45-47. Date of Electronic Publication: 2023 Jul 13.
The discovery of IsoPs has been an interesting development for a number of reasons, apart from the fact that it involves novel biochemistry. The simple fact that prostanoids are produced nonenzymatically in prodigous quantities in vivo and in much gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7383574d562c0bb478687f3c8800f2
https://doi.org/10.1385/1-59259-263-5:257
https://doi.org/10.1385/1-59259-263-5:257
Publikováno v:
Neurobiology of Disease, Vol 98, Iss , Pp 88-99 (2017)
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as g
Externí odkaz:
https://doaj.org/article/7b7809f333204bfe9153813bebc72318
Autor:
Christi T Salisbury-Ruf, Clinton C Bertram, Aurelia Vergeade, Daniel S Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W Gray Jerome, Quinn S Wells, Josh Fessel, Javid Moslehi, Heidi Chen, L Jackson Roberts II, Olivier Boutaud, Eric R Gamazon, Sandra S Zinkel
Publikováno v:
eLife, Vol 7 (2018)
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein B
Externí odkaz:
https://doaj.org/article/713e95df63974051b6c65861bd7d12a1
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1972-1979 (2013)
Despite animal and in vitro studies demonstrating pro-oxidative effects of Hg, previous human work showed no relationship between tissue Hg and plasma levels of F2-isoprostanes (IsoPs), a whole-body oxidative stress marker. We hypothesized that anoth
Externí odkaz:
https://doaj.org/article/fd449cd314c340a084307ab7a21b5eb5
Publikováno v:
In Free Radical Biology and Medicine 1999 27 Supplement 1:S50-S50
Publikováno v:
In Free Radical Biology and Medicine 1999 27 Supplement 1:S43-S43
Autor:
C. Blake Sullivan, Elena Matafonova, L. Jackson Roberts, II, Venkataraman Amarnath, Sean S. Davies
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 999-1009 (2010)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are γ-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions
Externí odkaz:
https://doaj.org/article/2734229a4cd34f52a4bd8558ff93b624
Autor:
Gopal K. Marathe, Kathleen A. Harrison, L. Jackson Roberts, II, Jason D. Morrow, Robert C. Murphy, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 4, Pp 587-596 (2001)
Unmitigated oxidative stress is deleterious, as epitomized by CCl4 intoxication. In this well-characterized model of free radical-initiated damage, liver metabolism of CCl4 to CCl3. causes lipid peroxidation, F-ring isoprostane formation, and patholo
Externí odkaz:
https://doaj.org/article/782ebb3db6c541f2b370e6269796dade