Zobrazeno 1 - 10
of 340
pro vyhledávání: '"L Jackson Roberts"'
Autor:
Christi T Salisbury-Ruf, Clinton C Bertram, Aurelia Vergeade, Daniel S Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W Gray Jerome, Quinn S Wells, Josh Fessel, Javid Moslehi, Heidi Chen, L Jackson Roberts II, Olivier Boutaud, Eric R Gamazon, Sandra S Zinkel
Publikováno v:
eLife, Vol 7 (2018)
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein B
Externí odkaz:
https://doaj.org/article/713e95df63974051b6c65861bd7d12a1
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117625 (2015)
Cardiopulmonary bypass (CPB) lyses erythrocytes and induces lipid peroxidation, indicated by increasing plasma concentrations of free hemoglobin, F2-isoprostanes, and isofurans. Acetaminophen attenuates hemeprotein-mediated lipid peroxidation, reduce
Externí odkaz:
https://doaj.org/article/1b8a1b716a93420583ca14bd9a51ac77
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47079 (2012)
ObjectivesIt is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflam
Externí odkaz:
https://doaj.org/article/ee5b90ab1cc14728990523ac23a1a160
Autor:
Youmin Zhang, Linda S. May-Zhang, L. Jackson Roberts, Sean S. Davies, Venkataraman Amarnath, Patricia G. Yancey, Jiansheng Huang, MacRae F. Linton, Lei Ding, Huan Tao, John A. Oates
Publikováno v:
Molecular Metabolism. 67:101651
ObjectiveOxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a8c678082182dc1bd35367affb68e9
https://doi.org/10.1016/j.molmet.2022.101651
https://doi.org/10.1016/j.molmet.2022.101651
Autor:
Elena Matafonova, Valery Yermalitsky, L. Jackson Roberts, Zhuoheng Li, Keri A. Tallman, William E. Zackert, Venkataraman Amarnath, Sean S. Davies
Publikováno v:
Analytical Biochemistry. 566:89-101
Isolevuglandins (IsoLGs) are a family of highly reactive 4-ketoaldehydes formed by lipid peroxidation that modify the lysyl residues of cellular proteins. Modification of proteins by IsoLGs have been shown to contribute to disease processes such as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0258f51eaaceddea6368369cbe8be6c
https://doi.org/10.1016/j.ab.2018.11.007
https://doi.org/10.1016/j.ab.2018.11.007
Autor:
Venkataraman Amarnath, Irene Zagol-Ikapitte, Alexander Panov, Anna Dikalova, Aurelia Vergeade, Frederic T. Billings, Liang Xiao, David G. Harrison, Sean S. Davies, Olivier Boutaud, Rafal R. Nazarewicz, L. Jackson Roberts, Sergey Dikalov, Valery Yermalitsky, Marcos G. Lopez, Mingfang Ao, Vladimir Mayorov
Publikováno v:
Hypertension
Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension, and mitochondria-targeted agents ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a837a006fe2af0b3c3ac487db813d0
https://pubmed.ncbi.nlm.nih.gov/33012204
https://pubmed.ncbi.nlm.nih.gov/33012204
Autor:
Anna Dikalova, Vladimir Mayorov, Liang Xiao, Alexander Panov, Venkataraman Amarnath, Irene Zagol-Ikapitte, Aurelia Vergeade, Mingfang Ao, Valery Yermalitsky, Rafal Nazarewicz, Olivier Boutaud, Marcos G Lopez, Frederic T Billings, Sean S Davies, L. Jackson Roberts, David G Harrison, Sergey I Dikalov
Publikováno v:
Hypertension. 76
Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension and mitochondria-targeted agents can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::878a5e217a94bc839b4662a9423e9dd5
https://doi.org/10.1161/hyp.76.suppl_1.p074
https://doi.org/10.1161/hyp.76.suppl_1.p074
Autor:
Patricia G. Yancey, Huan Tao, Jiansheng Huang, Lei Ding, Venkataraman Amarnath, Fei Ye, John L. Blakemore, John A. Oates, Sean S. Davies, L. Jackson Roberts, Valery Yermalitsky, Irene Zagol-Ikapitte, MacRae F. Linton, Olivier Boutaud, Youmin Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Lipid peroxidation generates reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that covalently modify proteins. Humans with familial hypercholesterolemia (FH) have increased lipoprotein dicarbonyl adducts and dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e77cbbe41e261534941edf6f906c6ee
http://europepmc.org/articles/PMC7429830
http://europepmc.org/articles/PMC7429830
Autor:
Naji N. Abumrad, Olivier Boutaud, Venkataraman Amarnath, Ginger L. Milne, Fei Ye, John A. Rathmacher, John A. Oates, Patricia M. Driver, Wendell S Akers, M. Benjamin Shoemaker, Sheau-Chiann Chen, L. Jackson Roberts, John C. Fuller, Lisa M. Pitchford
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, such as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba15e90b7bcabb7b2a1fd78c79f3fa2
https://doi.org/10.1186/s40360-020-0382-y
https://doi.org/10.1186/s40360-020-0382-y
Publikováno v:
Neurobiology of Disease, Vol 98, Iss, Pp 88-99 (2017)
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and Neuroketals, collectively known as g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfea46e85718cc951defe2041eeb9c07
http://www.sciencedirect.com/science/article/pii/S0969996116302790
http://www.sciencedirect.com/science/article/pii/S0969996116302790