Zobrazeno 1 - 10
of 362
pro vyhledávání: '"L Jackson Roberts"'
Autor:
Christi T Salisbury-Ruf, Clinton C Bertram, Aurelia Vergeade, Daniel S Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W Gray Jerome, Quinn S Wells, Josh Fessel, Javid Moslehi, Heidi Chen, L Jackson Roberts II, Olivier Boutaud, Eric R Gamazon, Sandra S Zinkel
Publikováno v:
eLife, Vol 7 (2018)
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein B
Externí odkaz:
https://doaj.org/article/713e95df63974051b6c65861bd7d12a1
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117625 (2015)
Cardiopulmonary bypass (CPB) lyses erythrocytes and induces lipid peroxidation, indicated by increasing plasma concentrations of free hemoglobin, F2-isoprostanes, and isofurans. Acetaminophen attenuates hemeprotein-mediated lipid peroxidation, reduce
Externí odkaz:
https://doaj.org/article/1b8a1b716a93420583ca14bd9a51ac77
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47079 (2012)
ObjectivesIt is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflam
Externí odkaz:
https://doaj.org/article/ee5b90ab1cc14728990523ac23a1a160
Autor:
Lisa M. Pitchford, Patricia M. Driver, John C. Fuller, Wendell S. Akers, Naji N. Abumrad, Venkataraman Amarnath, Ginger L. Milne, Sheau-Chiann Chen, Fei Ye, L. Jackson Roberts, M. Benjamin Shoemaker, John A. Oates, John A. Rathmacher, Olivier Boutaud
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, su
Externí odkaz:
https://doaj.org/article/aa4bb108a03440a0be1f206802adc5d2
Publikováno v:
Neurobiology of Disease, Vol 98, Iss , Pp 88-99 (2017)
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as g
Externí odkaz:
https://doaj.org/article/7b7809f333204bfe9153813bebc72318
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1972-1979 (2013)
Despite animal and in vitro studies demonstrating pro-oxidative effects of Hg, previous human work showed no relationship between tissue Hg and plasma levels of F2-isoprostanes (IsoPs), a whole-body oxidative stress marker. We hypothesized that anoth
Externí odkaz:
https://doaj.org/article/fd449cd314c340a084307ab7a21b5eb5
Autor:
Youmin Zhang, Linda S. May-Zhang, L. Jackson Roberts, Sean S. Davies, Venkataraman Amarnath, Patricia G. Yancey, Jiansheng Huang, MacRae F. Linton, Lei Ding, Huan Tao, John A. Oates
Publikováno v:
Molecular Metabolism. 67:101651
ObjectiveOxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a8c678082182dc1bd35367affb68e9
https://doi.org/10.1016/j.molmet.2022.101651
https://doi.org/10.1016/j.molmet.2022.101651
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 1, Pp 113-124 (2011)
15-Deoxy-Δ12,14-prostaglandin J2 (15-d-PGJ2) is a reactive cyclopentenone eicosanoid generated from the dehydration of cyclooxygenase-derived prostaglandin D2 (PGD2). This compound possesses an α,β-unsaturated carbonyl moiety that can readily addu
Externí odkaz:
https://doaj.org/article/7b82ac2cd0164f22a4752b850669f4ad
Autor:
C. Blake Sullivan, Elena Matafonova, L. Jackson Roberts, II, Venkataraman Amarnath, Sean S. Davies
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 999-1009 (2010)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are γ-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions
Externí odkaz:
https://doaj.org/article/2734229a4cd34f52a4bd8558ff93b624
Autor:
Elena Matafonova, Valery Yermalitsky, L. Jackson Roberts, Zhuoheng Li, Keri A. Tallman, William E. Zackert, Venkataraman Amarnath, Sean S. Davies
Publikováno v:
Analytical Biochemistry. 566:89-101
Isolevuglandins (IsoLGs) are a family of highly reactive 4-ketoaldehydes formed by lipid peroxidation that modify the lysyl residues of cellular proteins. Modification of proteins by IsoLGs have been shown to contribute to disease processes such as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0258f51eaaceddea6368369cbe8be6c
https://doi.org/10.1016/j.ab.2018.11.007
https://doi.org/10.1016/j.ab.2018.11.007