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The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects

Autor: Hubert Vidal, Patrick Schrauwen, Jan F. C. Glatz, Wim H. M. Saris, L J Slieker, Ellen E. Blaak, Gert Schaart

Publikováno v: Diabetologia, 43(11), 1408-1416. Springer, Cham

Aims/hypothesis. The aim of this study was to examine the effect of weight loss on UCP2/UCP3 mRNA expression and UCP3 protein content in subjects with Type II (non-insulin-dependent) diabetes mellitus.¶Methods. We studied seven Type II diabetic subj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e78f7a12e375701cc8d1540877c2aba
https://doi.org/10.1007/s001250051547

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Preparation of an Insulin with Improved Pharmacokinetics Relative to Human Insulin through Consideration of Structural Homology with Insulin-Like Growth Factor I

Autor: Harlan Beall Long, James E. Shields, L J Slieker, Ronald E. Chance, Richard D. DiMarchi

Publikováno v: Hormone Research. 41:93-96

The Diabetes Control and Complications Trial has emphasized the need for improved control of blood glucose as a means to diminish long-term complications of diabetes. LysPro-insulin is an analog of human insulin whose design was modeled on structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e626c6fb6f1ca1631163b97fc1f2c
https://doi.org/10.1159/000183967

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Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers

Autor: Hans A. Keizer, Patrick Schrauwen, Gert Schaart, Lars B. Borghouts, L J Slieker, Matthijs K. C. Hesselink, Wim H. M. Saris, C.F.P. Kornips, K.W. Sloop

Publikováno v: The FASEB Journal. 15:1071-1073

SPECIFIC AIMSHumanUCP3, predominantly expressed in skeletal muscle, plays an important role in the dissipation of energy in human energy metabolism and is therefore linked to obesity and type 2 diabetes. It has been deduced from rodent studies that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19ad4c9c8738bb0793cb3356d9fece2f
https://doi.org/10.1096/fj.00-0517fje

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(A-C-B) human proinsulin, a novel insulin agonist and intermediate in the synthesis of biosynthetic human insulin

Autor: S G Reams, L J Slieker, Harlan Beall Long, R M Belagaje, W F Heath, Walter N. Shaw, Gerald Stephen Brooke, Ronald E. Chance, C Roundtree, Jules A. Hoffmann

Publikováno v: Journal of Biological Chemistry. 267:419-425

The hormone insulin is synthesized in the beta cell of the pancreas as the precursor, proinsulin, where the carboxyl terminus of the B-chain is connected to the amino terminus of the A-chain by a connecting or C-peptide. Proinsulin is a weak insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9b98988c87152932241e272ee40aa14
https://doi.org/10.1016/s0021-9258(18)48511-0

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Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor

Autor: K L Sundell, Jules A. Hoffmann, L J Slieker, Gerald Stephen Brooke, L Fan, Harlan Beall Long, L K Green, Ronald E. Chance, Richard D. DiMarchi, David B. Flora, James E. Shields, P. L. Surface

Publikováno v: Diabetologia. 40

Inversion of the natural sequence of the B chain of human insulin (HI) from ProB28LysB29 to LysB28ProB29 generates an insulin analogue with reduced tendency to self-associate. Since this substitution increases the homology of insulin to insulin-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2a826ed7c01046aa5b2a68eecce6a5
https://pubmed.ncbi.nlm.nih.gov/9248702

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(A-C-B) human proinsulin, a novel insulin agonist and intermediate in the synthesis of biosynthetic human insulin

Autor: W F, Heath, R M, Belagaje, G S, Brooke, R E, Chance, J A, Hoffmann, H B, Long, S G, Reams, C, Roundtree, W N, Shaw, L J, Slieker

Publikováno v: The Journal of biological chemistry. 267(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::415fbbd6cdc569c103134546b0954456
https://pubmed.ncbi.nlm.nih.gov/1730606

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