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pro vyhledávání: '"L J J Derijks"'
P592 Effectiveness and safety of thioguanine in thiopurine-naïve Inflammatory Bowel Disease patients
Autor:
F Crouwel, A B Bayoumy, C J J Mulder, J H C Peters, P J Boekema, L J J Derijks, S Y De Boer, P C van de Meeberg, I Ahmad, H J C Buiter, N K de Boer
Publikováno v:
Journal of Crohn's and Colitis. 16:i529-i529
Background Currently thioguanine is considered as off-label rescue therapy for Inflammatory Bowel Disease (IBD) after conventional thiopurine failure. This study aimed to determine the safety, effectiveness and 12-month drug tolerability of thioguani
Publikováno v:
Scandinavian Journal of Gastroenterology. 38:69-72
Background Thiopurines have proven efficacy in inflammatory bowel disease. However, concerns regarding toxicity have limited the use of these agents as first line of medical therapy. Methods Review of the literature regarding metabolism, efficacy and
Publikováno v:
Gut, 57(6). BMJ Publishing Group
With great interest we read the article by Kaskas et al ( Gut 2003; 52 :140–2) about safe treatment of thiopurine S -methyltransferase (TPMT) deficient Crohn’s disease patients with azathioprine (AZA). In this paper it is illustrated that TPMT-de
Autor:
L P L, Gilissen, L J J, Derijks, A, Driessen, L P, Bos, P M, Hooymans, R W, Stockbrügger, L G J B, Engels
Publikováno v:
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 39(2)
6-Thioguanine is used in inflammatory bowel disease since 2001, with promising short-term results. In 2003, liver histology of some 6-thioguanine treated patients showed nodular regenerative hyperplasia. Recently, magnetic resonance imaging revealed