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T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis

Autor: D C Thomis, W Lee, L J Berg

Publikováno v: The Journal of Immunology. 159:4708-4719

The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors utilizing the common gamma-chain (gamma(c)). Mice and humans lacking Jak3 have severe immune deficiencies, including defects in B and T lymphocyte development a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d715ec8368095eab2740528ee663e898
https://doi.org/10.4049/jimmunol.159.10.4708

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Autor: D Yelon, L J Berg

Publikováno v: The Journal of Immunology. 158:5219-5228

Studies of TCR transgenic mice have demonstrated that in these systems positive selection is not an efficient process. The capacity of the thymus to produce mature T cells is limited, even when all immature thymocytes express appropriate Ag receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f809e404dc9ad595fa7d5c3355e1f92
https://doi.org/10.4049/jimmunol.158.11.5219

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A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes

Autor: L M Spain, J L Jorgensen, M M Davis, L J Berg

Publikováno v: The Journal of Immunology. 152:1709-1717

The developmental fate of an immature T cell is determined in the thymus. Depending on the specificity of its TCR, a thymocyte receives signals to either die or differentiate. We have used fetal thymic organ cultures derived from TCR transgenic mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7c7f81b350530141c89c07cb7d0706a
https://doi.org/10.4049/jimmunol.152.4.1709

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Boundary Layer Phenomena in Large Deflection, Small Strain Plate Theory

Autor: L. J. Berg

Publikováno v: Journal of Applied Mechanics. 60:229-232

Boundary layers exist at the edges of thin plates undergoing large deformations because the interior of the plate must assume a developable shape. The developable shape is sometimes incompatible with the force and moment resultants prescribed at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::021eaec8b9987338209a2c07f0bddb1d
https://doi.org/10.1115/1.2900759

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The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells

Autor: D C, Thomis, J, Aramburu, L J, Berg

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(10)

The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors using the common gamma-chain. Mice deficient in Jak3 have mature T cells, all of which have an activated/memory cell phenotype but are unresponsive to in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fcc824a14567631e931589a1b6bac32
https://pubmed.ncbi.nlm.nih.gov/10553066

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Dysregulated myelopoiesis in mice lacking Jak3

Autor: W J, Grossman, J W, Verbsky, L, Yang, L J, Berg, L E, Fields, D D, Chaplin, L, Ratner

Publikováno v: Blood. 94(3)

Jak3 is a cytoplasmic tyrosine kinase that associates with the common chain of the interleukin-2 (IL-2) receptor and is involved in the function of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Mice deficient in Jak3 have few T and B cells, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d997476513c752efe64900a59051c7d
https://pubmed.ncbi.nlm.nih.gov/10419884

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A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis

Autor: D M, Fernandes, A M, Baird, L J, Berg, K L, Rock

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(3)

E710.2.3 is a murine thymic lymphoma cell line with an immature phenotype (CD4-CD8-) that proliferates in response to thymocytes or PMA when cultured at low density and proliferates spontaneously when grown at high density. To identify functional mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68e82513537ef29f0177d5212d01dc11
https://pubmed.ncbi.nlm.nih.gov/10415028

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Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development

Autor: D, Yelon, K L, Schaefer, L J, Berg

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(3)

The T cell coreceptors CD4 and CD8 enhance T cell responses to TCR signals by participating in complexes containing TCR, coreceptor, and MHC molecules. These ternary complexes are also hypothesized to play a seminal role during T cell development, al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a97fd8b0ed6f8f4c7462e0d1f0d61606
https://pubmed.ncbi.nlm.nih.gov/9973389

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