Zobrazeno 1 - 10
of 289
pro vyhledávání: '"L J Berg"'
Publikováno v:
The Journal of Immunology. 159:4708-4719
The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors utilizing the common gamma-chain (gamma(c)). Mice and humans lacking Jak3 have severe immune deficiencies, including defects in B and T lymphocyte development a
Publikováno v:
The Journal of Immunology. 158:5219-5228
Studies of TCR transgenic mice have demonstrated that in these systems positive selection is not an efficient process. The capacity of the thymus to produce mature T cells is limited, even when all immature thymocytes express appropriate Ag receptors
Publikováno v:
The Journal of Immunology. 152:1709-1717
The developmental fate of an immature T cell is determined in the thymus. Depending on the specificity of its TCR, a thymocyte receives signals to either die or differentiate. We have used fetal thymic organ cultures derived from TCR transgenic mice
Autor:
L. J. Berg
Publikováno v:
Journal of Applied Mechanics. 60:229-232
Boundary layers exist at the edges of thin plates undergoing large deformations because the interior of the plate must assume a developable shape. The developable shape is sometimes incompatible with the force and moment resultants prescribed at the
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(10)
The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors using the common gamma-chain. Mice deficient in Jak3 have mature T cells, all of which have an activated/memory cell phenotype but are unresponsive to in vitro
Publikováno v:
Blood. 94(3)
Jak3 is a cytoplasmic tyrosine kinase that associates with the common chain of the interleukin-2 (IL-2) receptor and is involved in the function of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Mice deficient in Jak3 have few T and B cells, an
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(3)
E710.2.3 is a murine thymic lymphoma cell line with an immature phenotype (CD4-CD8-) that proliferates in response to thymocytes or PMA when cultured at low density and proliferates spontaneously when grown at high density. To identify functional mol
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(3)
The T cell coreceptors CD4 and CD8 enhance T cell responses to TCR signals by participating in complexes containing TCR, coreceptor, and MHC molecules. These ternary complexes are also hypothesized to play a seminal role during T cell development, al
Autor:
S C, Bunnell, L J, Berg
Publikováno v:
Genetic engineering. 20
Autor:
C B, Gurniak, L J, Berg
Publikováno v:
Oncogene. 13(4)
Using a PCR-based screen to identify tyrosine kinases involved in T cell development, we have cloned a new member of the Eph-family of receptor tyrosine kinases (Mep, for murine eph-family protein). At the amino acid level Mep is 60% identical to the