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Autor:
L. J. Rubin, M. Humbert
Publikováno v:
European Respiratory Review, Vol 18, Iss 113, Pp 135-136 (2009)
Externí odkaz:
https://doaj.org/article/7fa11a5a15004b919ece84b49b67c146
Publikováno v:
European Respiratory Journal. 33:1247-1249
The earliest clinical descriptions of primary pulmonary hypertension, now known as idiopathic pulmonary arterial hypertension (IPAH), were accompanied by the hypothesis that pulmonary vasoconstriction was one of its key pathophysiological elements 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda71b8ed58ea46600ab153bf1bbec29
https://doi.org/10.1183/09031936.00033809
https://doi.org/10.1183/09031936.00033809
Autor:
S P, Gaine, L J, Rubin
Publikováno v:
The American Journal of the Medical Sciences. 315:179-184
Significant advances in the treatment of pulmonary hypertension have been achieved in the past decade. Approximately one quarter of patients with primary pulmonary hypertension (PPH) can be effectively managed with chronic calcium channel blocker the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0927a8215076b379edb6e99c26933f13
https://doi.org/10.1097/00000441-199803000-00006
https://doi.org/10.1097/00000441-199803000-00006
Autor:
R J, Barst, L J, Rubin, W A, Long, M D, McGoon, S, Rich, D B, Badesch, B M, Groves, V F, Tapson, R C, Bourge, B H, Brundage, S K, Koerner, D, Langleben, C A, Keller, S, Murali, B F, Uretsky, L M, Clayton, M M, Jöbsis, S D, Blackburn, D, Shortino, J W, Crow, A, Krichman
Publikováno v:
New England Journal of Medicine. 334:296-301
Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospective, randomized trial to improve survival.We conducted a 12-week prospective, randomized, multicenter open trial comparing the effects of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fcdc722d85df856d288efb3642fa1b
https://doi.org/10.1056/nejm199602013340504
https://doi.org/10.1056/nejm199602013340504
Publikováno v:
American Journal of Physiology-Cell Physiology. 268:C259-C270
Cytochrome P-450 (P-450) is a NADPH-requiring and O2-dependent monooxygenase system. It is present in lung and has been postulated to act as an O2 sensor in hypoxic pulmonary vasoconstriction. To determine whether P-450 is involved in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af647aebf8c2fc44569d8771ad5501d
https://doi.org/10.1152/ajpcell.1995.268.1.c259
https://doi.org/10.1152/ajpcell.1995.268.1.c259
Publikováno v:
Scopus-Elsevier
Altered release of endothelium-derived relaxing factor/nitric oxide (EDRF/NO) has been proposed as a final common pathway underlying the abnormal vasodilator responses to gram-negative lipopolysaccharide (endotoxin). However, mechanisms responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b243539bd5b1609be438f7af010e4b11
https://doi.org/10.1161/01.res.75.4.659
https://doi.org/10.1161/01.res.75.4.659
Autor:
R. M. Palazzo, P. C. Tuteur, J. Theodore, J. R. Maurer, Talmadge E. King, Thomas M. Egan, J. D. Cooper, R. M. Bolman, Carol E. Vreim, B. P. Griffith, V. A. Starnes, M. I. Hertz, E. P. Trulock, I. L. Paradis, T. W. Higenbottam, R. A. Goldstein, L. J. Rubin, D. E. Low, A. C.G. Platzkev
Publikováno v:
American Review of Respiratory Disease. 147:772-776
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa5fa7c9fa69e70f0eb449b82340105
https://doi.org/10.1164/ajrccm/147.3.772
https://doi.org/10.1164/ajrccm/147.3.772
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 259:H281-H289
The effects of hypoxia on resting and K-stimulated tension were tested on small rings of rat pulmonary and mesenteric resistance arteries (SPA and SMA, respectively) and on the large branches of the main pulmonary artery (LPA). Reduction of PO2 from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a9d5e309f467b881af106d3cea1878
https://doi.org/10.1152/ajpheart.1990.259.2.h281
https://doi.org/10.1152/ajpheart.1990.259.2.h281
Autor:
S. H. Lee, L. J. Rubin
Publikováno v:
Journal of internal medicine. 258(3)
Pulmonary arterial hypertension (PAH) is a disease characterized by an elevation in pulmonary artery pressure that can lead to right ventricular failure and death. Although there is no cure for PAH, newer medical therapies have been shown to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef19e8b1eb54eab5eb653344b4321386
https://pubmed.ncbi.nlm.nih.gov/16115293
https://pubmed.ncbi.nlm.nih.gov/16115293