Common genetic variants do not predict recurrent events in coronary heart disease patients

Autor: P. L. Thompson, J. Hui, J. Beilby, L. J. Palmer, G. F. Watts, M. J. West, A. Kirby, S. Marschner, R. J. Simes, D. R. Sullivan, H. D. White, R. Stewart, A. M. Tonkin

Publikováno v: BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-9 (2022)

Abstract Background It is unclear whether genetic variants identified from single nucleotide polymorphisms (SNPs) strongly associated with coronary heart disease (CHD) in genome-wide association studies (GWAS), or a genetic risk score (GRS) derived f

Externí odkaz: https://doaj.org/article/96fab9ee494749348d0580cefb62476e

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Autor: D. L. Cousminer, D. J. Berry, N. J. Timpson, W. Ang, E. Thiering, E. M. Byrne, H. R. Taal, V. Huikari, J. P. Bradfield, M. Kerkhof, M. M. Groen Blokhuis, E. Kreiner Moller, M. Marinelli, C. Holst, J. T. Leinonen, J. R. B. Perry, I. Surakka, O. Pietilainen, J. Kettunen, V. Anttila, M. Kaakinen, U. Sovio, A. Pouta, S. Das, V. Lagou, C. Power, I. Prokopenko, D. M. Evans, J. P. Kemp, B. St Pourcain, S. Ring, A. Palotie, E. Kajantie, C. Osmond, T. Lehtimaki, J. S. Viikari, M. Kahonen, N. M. Warrington, S. J. Lye, L. J. Palmer, C. M. T. Tiesler, C. Flexeder, G. W. Montgomery, S. E. Medland, A. Hofman, H. Hakonarson, M. Guxens, M. Bartels, V. Salomaa, J. M. Murabito, J. Kaprio, T. I. A. Sorensen, F. Ballester, H. Bisgaard, D. I. Boomsma, G. H. Koppelman, S. F. A. Grant, V. W. V. Jaddoe, N. G. Martin, J. Heinrich, C. E. Pennell, O. T. Raitakari, J. G. Eriksson, G. D. Smith, E. Hypponen, M. R. Jarvelin, M. I. McCarthy, S. Ripatti, E. Widen, Adair LS, Ang W, Atalay M, van Beijsterveldt T, Bergen N, Benke K, Berry DJ, Boomsma DI, Bradfield JP, Charoen P, Coin L, Cooper C, Cousminer DL, Das S, Davis OS, Dedoussis GV, Elliott P, Estivill X, Evans DM, Feenstra B, Flexeder C, Frayling T, Freathy RM, Gaillard R, Geller F, Gillman M, Grant SF, Groen Blokhuis M, Goh LK, Guxens M, Hakonarson H, Hattersley AT, Haworth CM, Hadley D, Hedebrand J, Heinrich J, Hinney A, Hirschhorn JN, Hocher B, Holloway JW, Holst C, Hottenga JJ, Horikoshi M, Huikari V, Hypponen E, Iñiguez C, Jaddoe VW, Jarvelin MR, Kaakinen M, Kilpeläinen TO, Kirin M, Kowgier M, Lakka HM, Lakka TA, Lange LA, Lawlor DA, Lehtimäki T, Lewin A, Lindgren C, Lindi V, Maggi R, Marsh J, McCarthy MI, Melbye M, Middeldorp C, Millwood I, Mohlke KL, Mook Kanamori DO, Murray JC, Nivard M, Nohr EA, Ntalla I, Oken E, Ong KK, O'Reilly PF, Palmer LJ, Panoutsopoulou K, Pararajasingham J, Pearson ER, Pennell CE, Power C, Price TS, Prokopenko I, Raitakari OT, Rodriguez A, Salem RM, Saw SM, Scherag A, Sebert S, Siitonen N, Simell O, Sørensen TI, Sovio U, Pourcain BS, Strachan DP, Sunyer J, Taal HR, Teo YY, Thiering E, Tiesler C, Timpson NJ, Uitterlinden AG, Valcárcel B, Warrington NM, White S, Widén E, Willemsen G, Wilson JF, Yaghootkar H, Zeggini E, Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Gudbjartsson DF, Esko T, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SH, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PK, Smith EN, Ulivi S, Warrington M, Zgaga L, Alavere H, Amin N, Aspelund T, Bandinelli S, Barroso I, Berenson GS, Bergmann S, Blackburn H, Boerwinkle E, Buring JE, Busonero F, Campbell H, Chanock SJ, Chen W, Cornelis MC, Couper D, Coviello AD, de Faire U, de Geus EJ, Deloukas P, Döring A, Davey Smith G, Easton DF, Eiriksdottir G, Emilsson V, Eriksson J, Ferrucci L, Folsom AR, Foroud T, Garcia M, GASPARINI, PAOLO, Gieger C, Gudnason V, Hall P, Hankinson SE, Ferreli L, Heath AC, Hernandez DG, Hofman A, Hu FB, Illig T, Järvelin MR, Johnson AD, Karasik D, Khaw KT, Kiel DP, Kolcic I, Kraft P, Launer LJ, Laven JS, Li S, Liu J, Levy D, Martin NG, McArdle WL, Mooser V, Murray SS, Nalls MA, Navarro P, Nelis M, Ness AR, Northstone K, Oostra BA, Peacock M, Palotie A, Paré G, Parker AN, Pedersen NL, Peltonen L, Pharoah P, Polasek O, Plump AS, Pouta A, Porcu E, Rafnar T, Rice JP, Ring SM, Rivadeneira F, Rudan I, Sala C, Salomaa V, Sanna S, Schlessinger D, Schork NJ, Scuteri A, Segrè AV, Shuldiner AR, Soranzo N, Srinivasan SR, Tammesoo ML, Tikkanen E, Toniolo D, Tsui K, Tryggvadottir L, Tyrer J, Uda M, van Dam RM, van Meurs JB, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Weedon MN, Wichmann HE, Wright AF, Young L, Zhai G, Zhuang WV, Bierut LJ, Boyd HA, Crisponi L, Demerath EW, van Duijn CM, Econs MJ, Harris TB, Hunter DJ, Loos RJ, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Widen E, Murabito JM, Murray A., D'ADAMO, ADAMO PIO

Publikováno v: Human Molecular Genetics Vol. 22 Issue 13: pp. 2735-2747
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Human Molecular Genetics
Hum. Mol. Genet. 22, 2735-2747 (2013)
HUMAN MOLECULAR GENETICS
r-FISABIO. Repositorio Institucional de Producción Científica
Human Molecular Genetics; Vol 22
Cousminer, D L, Berry, D J, Timpson, N J, Ang, W, Thiering, E, Byrne, E M, Taal, H R, Huikari, V, Bradfield, J P, Kerkhof, M, Groen-Blokhuis, M M, Kreiner-Møller, E, Marinelli, M, Holst, C, Leinonen, J T, Perry, J R, Surakka, I, Pietilainen, O P, Kettunen, J, Anttila, V, Kaakinen, M, Sovio, U, Pouta, A, Das, S, Lagou, V, Power, C, Prokopenko, I, Evans, D M, Kemp, J P, St Pourcain, B, Ring, S M, Palotie, A, Kajantie, E, Osmond, C, Lehtimäki, T, Viikari, J S, Kähönen, M, Warrington, N M, Lye, S J, Palmer, L J, Tiesler, C M T, Flexeder, C, Montgomery, G W, Medland, S E, Hofman, A, Hakonarson, H, Guxens, M, Bartels, M, Salomaa, V, Adair, L S, Atalay, M, van Beijsterveldt, C E M, Bergen, N, Benke, K S, Charoen, P, Coin, L, Cooper, C, Davis, O S, Dedoussis, G V, Elliott, P, Estivill, X, Feenstra, B, Frayling, T M, Freathy, R M, Gaillard, R, Geller, F, Gillman, M W, Goh, L K, Hattersley, A T, Haworth, C M, Hadley, D, Hedebrand, J, Hinney, A, Hirschhorn, J N, Hocher, B, Holloway, J W, Hottenga, J J, Horikoshi, M, Iñiguez, C, Järvelin, M R, Kilpeläinen, T O, Kirin, M, Kowgier, M, Lakka, H M, Lakka, T A, Lange, L A, Lawlor, D A, Lewin, A, Lindgren, C M, Lindi, V, Maggi, R, Marsh, J, Melbye, M, Middeldorp, C M, Millwood, I, Mohlke, K L, Mook-Kanamori, D O, Murray, J C, Nivard, M G, Nohr, E A, Ntalla, I, Oken, E, Ong, K K, O'Reilly, P F, Panoutsopoulou, K, Pararajasingham, J, Pearson, E R, Price, T S, Rodriguez, A, Salem, R M, Saw, S M, Scherag, A, Sebert, S, Siitonen, N, Simell, O, Strachan, D P, Sunyer, J, Teo, Y Y, Uitterlinden, A G, Valcárcel, B, White, S, Widén, E, Willemsen, G, Wilson, J F, Yaghootkar, H, Zeggini, E, Elks, C E, Sulem, P, Chasman, D I, Franceschini, N, He, C, Lunetta, K L, Visser, J A, Gudbjartsson, D F, Esko, T, Koller, D L, Kutalik, Z, Lin, P, Mangino, M, Marongiu, M, McArdle, P F, Smith, A V, Stolk, L, van Wingerden, S, Zhao, J H, Albrecht, E, Corre, T, Ingelsson, E, Hayward, C, Magnusson, P K E, Smith, E N, Ulivi, S, Warrington, M, Zgaga, L, Alavere, H, Amin, N, Aspelund, T, Bandinelli, S, Barroso, I, Berenson, G S, Bergmann, S, Blackburn, H, Boerwinkle, E, Buring, J E, Busonero, F, Campbell, H, Chanock, S J, Chen, W, Cornelis, M C, Couper, D, Coviello, A D, d'Adamo, P, de Faire, U, de Geus, E J C, Deloukas, P, Döring, A, Davey Smith, G, Easton, D F, Eiriksdottir, G, Emilsson, V, Ferrucci, L, Folsom, A R, Foroud, T, Garcia, M, Gasparini, P, Gieger, C, Gudnason, V, Hall, P, Hankinson, S E, Ferreli, L, Heath, A C, Hernandez, D G, Hu, F B, Illig, T, Johnson, A D, Karasik, D, Khaw, K T, Kiel, D P, Kolcic, I, Kraft, P, Launer, L J, Laven, J S, Li, S, Liu, J, Levy, D, McArdle, W L, Mooser, V, Murray, S S, Nalls, M A, Navarro, P, Nelis, M, Ness, A R, Northstone, K, Oostra, B A, Peacock, M, Paré, G, Parker, A N, Pedersen, N L, Peltonen, L, Pennell, C E, Pharoah, P, Polasek, O, Plump, A S, Porcu, E, Rafnar, T, Rice, J P, Rivadeneira, F, Rudan, I, Sala, C, Sanna, S, Schlessinger, D, Schork, N J, Scuteri, A, Segrè, A V, Shuldiner, A R, Soranzo, N, Srinivasan, S R, Tammesoo, M L, Tikkanen, E, Toniolo, D, Tsui, K, Tryggvadottir, L, Tyrer, J, Uda, M, Dam, R M, van Meurs, J B, Vollenweider, P, Waeber, G, Wareham, N J, Waterworth, D, Weedon, M N, Wichmann, H E, Wright, A F, Young, L, Zhai, G, Zhuang, W V, Bierut, L J, Boyd, H A, Crisponi, L, Demerath, E W, van Duijn, C M, Econs, M J, Harris, T B, Hunter, D J, Loos, R J, Metspalu, A, Ridker, P M, Spector, T D, Streeten, E A, Stefansson, K, Thorsteinsdottir, U, Murray, A, Murabito, J M, Kaprio, J, Sørensen, T I A, Ballester, F, Bisgaard, H, Boomsma, D I, Koppelman, G H, Grant, S F, Jaddoe, V W, Martin, N G, Heinrich, J, Raitakari, O T, Eriksson, J G, Smith, G D, Hyppönen, E, McCarthy, M I & Ripatti, S 2013, ' Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth pubertal timing and childhood adiposity ', Human Molecular Genetics, vol. 22, no. 13, pp. 2735-2747 . https://doi.org/10.1093/hmg/ddt104
Human Molecular Genetics, 22(13), 2735-2747. Oxford University Press
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b26d537e0fd4cd246c06c21c1a378f
https://hdl.handle.net/1959.8/152978

Phylogenetic analysis and molecular methods for the detection of lymphocystis disease virus from yellow perch, Perca flavescens (Mitchell)

Autor: L J, Palmer, N S, Hogan, M R, van den Heuvel

Publikováno v: Journal of fish diseases. 35(9)

Lymphocystis disease is a prevalent, non-fatal disease that affects many teleost fish and is caused by the DNA virus lymphocystis disease virus (LCDV). Lymphocystis-like lesions have been observed in yellow perch, Perca flavescens (Mitchell), in lake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b9584a4c01354705466d2c85345c05f
https://pubmed.ncbi.nlm.nih.gov/22804739

Severe hypoglycemia due to overdose of insulin; recovery with cerebral damage

Autor: L J, PALMER, A H B, PEDERSEN

Publikováno v: Clinics of the Virginia Mason Hospital. 24(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ee6cc95e57d0c4274dec01d03d7f22b
https://pubmed.ncbi.nlm.nih.gov/20261274

Linkages and associations to intermediate phenotypes underlying asthma and allergic disease

Autor: L J, Palmer

Publikováno v: Current opinion in allergy and clinical immunology. 1(5)

Considerable effort and expense has been expended in attempts to detect specific polymorphisms in genetic loci contributing to susceptibility to allergic diseases. Increasingly, 'intermediate' phenotypes for asthma and other allergic diseases have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aac41971c24360bae36a3abd190ecf95
https://pubmed.ncbi.nlm.nih.gov/11964718