The effect of fluoride on the structure, function, and proteome of intestinal epithelia

Autor: Flávia Amadeu de Oliveira, Simran Amin, J. Michael Edwardson, Maria Pieri, Aline de Lima Leite, Chetanya Sharma, Mariana R. Santesso, Ioanna Mela, L J MacVinish, Zohaib Nisar Khan, Duleni Herath, Rodrigo Cardoso de Oliveira, Gavin E. Jarvis, Marília Afonso Rabelo Buzalaf, Flávia Mauad Levy, Pia Jeggle

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f174e44f98da1a7f048abb1d82e8a2
https://doi.org/10.1002/tox.22495

Intra-amniotic Delivery of CFTR-expressing Adenovirus Does Not Reverse Cystic Fibrosis Phenotype in Inbred CFTR-knockout Mice

Autor: Suzanne M. K. Buckley, Alan W. Cuthbert, S Jezzard, Simon N. Waddington, A Bergau, William H. Colledge, L J MacVinish, Charles Coutelle, Michael Themis

Publikováno v: Molecular Therapy. 16(5):819-824

This article is available open access through the publisher’s website at the link below. Copyright © 2008 The American Society of Gene Therapy. Due to its early onset and severe prognosis, cystic fibrosis (CF) has been suggested as a candidate dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4c3b6bc1692c833751d9640cc5a256

4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells

Autor: L J MacVinish, Alan W. Cuthbert, Meena Murthy, A J Szkotak, Marek Duszyk

Publikováno v: British Journal of Pharmacology. 142:531-542

Calu-3 cells have been used to investigate the actions of 4-chloro-benzo[F]isoquinoline (CBIQ) on short-circuit current (SCC) in monolayers, whole-cell recording from single cells and by patch clamping. CBIQ caused a sustained, reversible and repeata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93d231f6c5926e87abf56f92fe427f91
https://doi.org/10.1038/sj.bjp.0705846

Selective in vivo transfection of murine biliary epithelia using polycation-enhanced adenovirus

Autor: Michael Themis, A Pavirani, S Jezzard, Robert D. Goldin, M. E. Hickman, Tristan R. McKay, Alan W. Cuthbert, Charles Coutelle, Ben Carpenter, L J MacVinish

Publikováno v: Gene Therapy. 7:644-652

We have investigated the use of polycations to increase adenovirus-mediated expression of transgenic protein to the biliary epithelia with a view to gene therapy for hepatobiliary disease in CF. We have shown that adenovirus carrying the β-galactosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54abfde02556694c69d55f615ab0d6e0
https://doi.org/10.1038/sj.gt.3301144

Importance of basolateral K+conductance in maintaining Cl−secretion in murine nasal and colonic epithelia

Autor: Alan W. Cuthbert, Dina A. H. Mufti, Hannah J. Durrington, M. E. Hickman, L J MacVinish

Publikováno v: The Journal of Physiology. 510:237-247

The hyperpolarization of the apical membrane which results from the activation of basolateral K+ channels increases the driving force for the exit of Cl− ions in electrogenic secretory epithelia, as first proposed by Smith & Frizzel in 1984. In sit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e1383769141873d17743f7d5b64b71
https://doi.org/10.1111/j.1469-7793.1998.237bz.x