Zobrazeno 1 - 10
of 30
pro vyhledávání: '"L J, Hammond"'
Autor:
R. Mirakian, Nasim Yousaf, Michael F. McDermott, Graham A. Hitman, Yuti Chernajovsky, L. J. Hammond, Mark D. Turner, David Gould, Ebun Aganna
Publikováno v:
Arthritis & Rheumatism. 52:2906-2916
Objective To investigate the molecular consequences of expressing mutated forms of tumor necrosis factor receptor I (TNFRI) as found in patients with TNFR-associated periodic syndrome (TRAPS). Methods We cloned and expressed full-length wild-type (WT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9aaddc3bc4a76060c82128a06feb04
https://doi.org/10.1002/art.21268
https://doi.org/10.1002/art.21268
Autor:
Philip N. Hawkins, Sharron Worthington, Michael G. Molloy, Nicholas Baker, Michael F. McDermott, Juan I. Aróstegui, Jeff L. Bidwell, Joost Frenkel, José L. Castañer, Margo Whiteford, Graham A. Hitman, L. J. Hammond, Helen J. Lachmann, Jordi Yagüe, Shane McKee, Pilar Solis, Micaela La Regina, Kirsten Minden, Kevin P. High, Richard J. Powell, Elizabeth M. McDermott, P. L. Janssens-Korpola, Josep M. Campistol, Koichi Kusuhara, Claudia Mischung, Alison Bybee, Ebun Aganna, R. Mirakian, Anna Aldea, Hans Kristian Ploos van Amstel, Raffaele Manna, Frank T. Saulsbury, Patricia Woo
Publikováno v:
Arthritis & Rheumatism. 48:2632-2644
Objective To investigate the prevalence of tumor necrosis factor receptor–associated periodic syndrome (TRAPS) among outpatients presenting with recurrent fevers and clinical features consistent with TRAPS. Methods Mutational screening was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5355de41b261852a59321fcca082990b
https://doi.org/10.1002/art.11215
https://doi.org/10.1002/art.11215
Publikováno v:
Journal of Immunological Methods. 265:161-175
Over the last few years, the importance of apoptosis in determining the fate of thyrocytes in autoimmune thyroid disease has been the topic of intense investigation. It is now clear that thyrocytes from patients with Hashimoto's thyroiditis are destr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5754e5473c0b8dbd2dfdee7d588920
https://doi.org/10.1016/s0022-1759(02)00078-9
https://doi.org/10.1016/s0022-1759(02)00078-9
Publikováno v:
Thyroid. 11:919-927
In Hashimoto's thyroiditis, thyrocytes die by apoptosis. Whether this is the result of impaired antiapoptotic gene expression or hyperexpression of proapoptotic signals or other mechanisms is not fully established. Following the suggestion that thyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629d61faa8cb50668f0fbc17d6fab4d1
https://doi.org/10.1089/105072501753210975
https://doi.org/10.1089/105072501753210975
Publikováno v:
Thyroid. 10:561-572
Programmed cell death or apoptosis is central both in physiology during development and in disease. The mechanism of apoptosis is under the control of antiapoptotic survival genes of the Bcl-2 family and proapoptotic death receptors of the TNF superf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9cb34a44efb2f60fab0840cd5d31002
https://doi.org/10.1089/thy.2000.10.561
https://doi.org/10.1089/thy.2000.10.561
Autor:
Alessandra Fierabracci, L. J. Hammond, G. F. Bottazzo, A. W. Goode, R Mirakian, Luca Chiovato, Mark W. Lowdell
Publikováno v:
Journal of Autoimmunity. 12:305-314
Microbial superantigens have been implicated in the pathogenesis of human autoimmune diseases. In autoimmune glands, thyrocytes inappropriately express HLA-DR molecules and these cells may function as antigen presenting cells (APC) We studied the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a84360e38d4d94f911909f691dcb61
https://doi.org/10.1006/jaut.1999.0279
https://doi.org/10.1006/jaut.1999.0279
Publikováno v:
The Journal of Pathology. 182:138-144
The level of apoptosis has been investigated in thyroid tissue from eight patients with Graves's disease, one with Hashitoxicosis, three with Hashimoto's thyroiditis, and five patients with multinodular goitre, using flow cytometry and an in situ imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8ed922e5a10c8c45bd817e49d36dd1
https://doi.org/10.1002/(sici)1096-9896(199706)182:2<138::aid-path810>3.0.co
https://doi.org/10.1002/(sici)1096-9896(199706)182:2<138::aid-path810>3.0.co
Autor:
Francesco Saverio Ambesi-Impiombato, L. J. Hammond, Rita Mirakian, Paul Andrew Biro, G. F. Bottazzo, Z. Wu, Francesco Curcio
SUMMARYExpression of HLA class II molecules on thyrocytes is a characteristic feature of autoimmune thyroid disease and may lead the thyroid cells to present autoantigens to CD4+ T lymphocytes. Since HLA-DM is a critical molecule in class II-restrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c448aba0a0116bc0c66c1f0e89404
http://hdl.handle.net/11390/883758
http://hdl.handle.net/11390/883758
IL-10 is a cytokine which not only suppresses cellular immunity but also stimulates the humoral response. In certain animal models of autoimmunity, IL-10 exerts a protective effect against auto-destruction. This study was to ascertain whether there c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add3195a3f8f0bf3e5d467609dbb93ac
https://europepmc.org/articles/PMC1905025/
https://europepmc.org/articles/PMC1905025/
Publikováno v:
Immunology today. 19(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::431e4a811e7529086f4ccdb8e5e1919e
https://pubmed.ncbi.nlm.nih.gov/9153948
https://pubmed.ncbi.nlm.nih.gov/9153948