HSP90: A potential drug target in inflammatory skin diseases

Autor: A. H. Rittig, A. Bregnhøj, C. Johansen, L. Iversen

Publikováno v: JEADV Clinical Practice, Vol 2, Iss 3, Pp 450-455 (2023)

Abstract Heat shock protein 90 (HSP90) is a chaperone protein belonging to the HSP family. HSP90 modulates clients by stabilising, folding, maturing, and tagging clients for proteasomal degradation. Several clients of HSP90 are involved in cancer dev

Externí odkaz: https://doaj.org/article/3ad1443865d14773a678067fdd3d423e

Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus

Autor: Travis K. Warren, Christopher D. Kane, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Jesse Steffens, Laura Gomba, Jessica M. Weidner, Sarah Norris, Xiankun Zeng, Roy Bannister, Tomas Cihlar, Sina Bavari, Danielle P. Porter, Patrick L. Iversen

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory l

Externí odkaz: https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c

Eastern equine encephalitis virus rapidly infects and disseminates in the brain and spinal cord of cynomolgus macaques following aerosol challenge

Autor: Janice A. Williams, Simon Y. Long, Xiankun Zeng, Kathleen Kuehl, April M. Babka, Neil M. Davis, Jun Liu, John C. Trefry, Sharon Daye, Paul R. Facemire, Patrick L. Iversen, Sina Bavari, Margaret L. Pitt, Farooq Nasar

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 5 (2022)

Eastern equine encephalitis virus (EEEV) is mosquito-borne virus that produces fatal encephalitis in humans. We recently conducted a first of its kind study to investigate EEEV clinical disease course following aerosol challenge in a cynomolgus macaq

Externí odkaz: https://doaj.org/article/4f5acd08ce834e0ab487c8ee28a4c1e2

Author Correction: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease

Autor: Kevin A. Lidberg, Andrew J. Annalora, Marija Jozic, Daniel J. Elson, Lu Wang, Theo K. Bammler, Susanne Ramm, Maria Beatriz Monteiro, Jonathan Himmelfarb, Craig B. Marcus, Patrick L. Iversen, Edward J. Kelly

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/ffc507cf83ba4185b5e5704e026f577d

Prevalence and characterization of treatment-refractory psoriasis and super-responders to biologic treatment:a nationwide study

Autor: N. Loft, A. Egeberg, M.K. Rasmussen, L.E. Bryld, C.V. Nissen, T.N. Dam, K.K. Ajgeiy, L. Iversen, L. Skov

Publikováno v: Loft, N, Egeberg, A, Rasmussen, M K, Bryld, L E, Nissen, C V, Dam, T N, Ajgeiy, K K, Iversen, L & Skov, L 2022, ' Prevalence and characterization of treatment-refractory psoriasis and super-responders to biologic treatment : a nationwide study ', Journal of the European Academy of Dermatology and Venereology, vol. 36, no. 8, pp. 1284-1291 . https://doi.org/10.1111/jdv.18126
Loft, N, Egeberg, A, Rasmussen, M K, Bryld, L E, Nissen, C, Dam, T N, Ajgeiy, K K, Iversen, L & Skov, L 2022, ' Prevalence and characterization of treatment-refractory psoriasis and super-responders to biologic treatment : a nationwide study ', Journal of the European Academy of Dermatology and Venereology, vol. 36, no. 8, pp. 1284-1291 . https://doi.org/10.1111/jdv.18126

Introduction Treatment with biologics often leads to clearance of psoriasis. However, some patients do repeatedly fail to respond and/or lose an achieved response (treatment refractory) to the biologic, whereas other patients achieve excellent respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bbb7580ca2cc6829c570070143271b
https://pure.au.dk/portal/da/publications/prevalence-and-characterization-of-treatmentrefractory-psoriasis-and-superresponders-to-biologic-treatment(85b8f643-9fba-4c8c-a312-dd14046b7e85).html