Zobrazeno 1 - 10
of 18
pro vyhledávání: '"L I Harrison"'
Publikováno v:
Biopharmaceuticsdrug disposition. 19(5)
3M has formulated a new chlorofluorocarbon-free (CFC-free) beclomethasone dipropionate (BDP) metered-dose inhaler (MDI) with the use of the propellant HFA-134a (HFA). Lung deposition studies demonstrated that the HFA BDP MDI delivers to the lungs app
Autor:
L I, Harrison, D R, Dahl, A, Cline, S F, Chang, J, Machacek, J, Nelson, C, Kannianinen, A, Purrington
Publikováno v:
Biopharmaceuticsdrug disposition. 18(7)
As part of a development program to offer alternatives to chlorofluorocarbon (CFC) containing metered-dose inhalers, beclomethasone dipropionate has been formulated in a CFC-free system at three strengths: 50, 100, and 200 micrograms/actuation ex val
Autor:
L I, Harrison, D J, Riedel
Publikováno v:
Clinical therapeutics. 13(3)
A number of transdermal nitroglycerin delivery systems are able to maintain a constant plasma level of nitroglycerin for up to 24 hours, even though the drug's elimination half-life is only a few minutes. Unfortunately, wide variations in plasma drug
Publikováno v:
Journal of Pharmaceutical Sciences. 69:1268-1271
A high-pressure liquid chromatographic method was developed for the separation and quantitation of salicylsalicylic acid (I), aspirin (II), and salicylic acid (III) in human plasma and urine. The method for plasma involves the selective extraction of
Autor:
M L Funk, L I Harrison, D Schuppan, A R Hansen, S R Rohlfing, C S Hansen, R E Ober, S H Collins
Publikováno v:
Antimicrobial Agents and Chemotherapy. 25:301-305
A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentra
Publikováno v:
Therapeutic Drug Monitoring. 5:401-404
Plasma salicyclic acid levels from the recommended multiple dose regimen of Norgesic Forte (orphenadrine citrate, aspirin, and caffeine) were compared to those from an equivalent multiple dose regimen of aspirin alone in 24 volunteers. The drugs were
Publikováno v:
Clinical therapeutics. 4(1)
This single-dose, three-way crossover study in 18 healthy adults compared the oral absorption of theophylline from a theophylline-guaifenesin tablet and from a theophylline-guaifenesin liquid with absorption from a theophylline liquid. Each dose form
Autor:
L I, Harrison, M, Gibaldi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 4(1)
Previous studies on the pharmacokinetics of 3H-digoxin in the rat have been based on total radioactivity in the plasma, even though the drug is extensively metabolized in this species. A comparison of total radioactivity vs. unchanged drug in rat pla
Autor:
D J, Riedel, K A, Wick, R W, Hawkinson, C A, Kolars, J K, Crowley, K E, Armstrong, S F, Chang, L I, Harrison, S R, de Dennis
Publikováno v:
Clinical therapeutics. 11(2)
This two-period crossover study in 24 healthy men compared the transdermal absorption of nitroglycerin from a new 20-cm2 nitroglycerin adhesive transdermal patch applied for a single 24-hour period (q24hr) with that from one inch of 2% nitroglycerin
Publikováno v:
Journal of bacteriology. 122(3)
The uptake of L-4-azaleucine was examined in Escherichia coli K-12 strains to determine the systems that serve for its accumulation. L-4=Azaleucine in radio-labeled form was synthesized and resolved by the action of hog kidney N-acylamino-acid amidoh