Zobrazeno 1 - 10
of 55
pro vyhledávání: '"L I, Wiebe"'
Publikováno v:
Medicinal Chemistry. 5:118-129
18F-Labelled fluoroazomycin arabinoside ([18F]FAZA) is a 2-nitroimidazole (azomycin) based PET tracer used extensively in cancer clinics to diagnose tumour hypoxia. The hypoxia-specific uptake and rapid blood clearance kinetics of FAZA contribute to
Publikováno v:
Letters in Drug Design & Discovery. 6:82-85
Publikováno v:
Radiochemistry. 47:204-208
Seven new nitrophenol derivatives were synthesized; their 99m Tc complexes (N2OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [99m Tc]NaTcO4 in the presence of SnCl2 at pH 10. The in vitro biostabilty
Publikováno v:
Journal of Carbohydrate Chemistry. 18:209-223
Three fluorinated β-cyclodextrin derivatives, namely 5, 9 and 12, were prepared with the hope that the fluorine reporter group may assist in direct evaluation of the complexation properties of these potential drug carriers. Two of the synthesized de
Publikováno v:
British Journal of Cancer
Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The poss
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 5(2)
(18)F-Labelled fluoroazomycin arabinoside ([(18)F]FAZA) is a 2-nitroimidazole (azomycin) based PET tracer used extensively in cancer clinics to diagnose tumour hypoxia. The hypoxia-specific uptake and rapid blood clearance kinetics of FAZA contribute
Autor:
H-F, Li, A, Winkeler, S, Moharram, E E, Knaus, K, Dittmar, M, Stöckle, W D, Heiss, L I, Wiebe, A H, Jacobs, A J, Jacob
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 27(1)
Radioiodinated 5-iodo-1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)uracil (F *IAU) is most commonly used for noninvasive assessment of herpes simplex virus type 1 thymidine kinase (HSV-1-tk) gene expression. However, it does not permeate the intact bl
Publikováno v:
Pharmaceutical Chemistry Journal. 40
The synthesis of seven 99mTc-labeled nitrophenol radiosensitizers (N2OS chelates) was undertaken for evaluating their in vitro biostabilty as possible hypoxia tumor imaging agents. The title compounds (2–7) were successively synthesized, characteri
Autor:
L I, Wiebe
Publikováno v:
IDrugs : the investigational drugs journal. 2(12)
Functional diagnostic imaging techniques, including planar radioscintography, single photon emission tomography, positron emission tomography and computed magnetic resonance imaging, are universally-accepted procedures in medical diagnosis. This symp
Autor:
L I, Wiebe
Publikováno v:
IDrugs : the investigational drugs journal. 3(3)
The field of drug delivery is moving rapidly from the more efficacious delivery of 'old' drugs, to the delivery of therapeutic peptides, proteins, oligonucleotides and genes. Liposomes, polymers, microbubbles, nanoparticles, wafers and chips are the