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Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

Autor: S A, Weitzman, L I, Gordon

Publikováno v: Blood. 76:655-663

We have reviewed some of the data that link the reactive oxygen species produced by inflammatory phagocytes to cancer development. While it is clear that these substances induce phenotypic changes characteristic of those produced by known carcinogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f04a2d1f35de01d2af5cc2d8f0f02e
https://doi.org/10.1182/blood.v76.4.655.bloodjournal764655

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Does younger donor age affect the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?

Autor: J, Mehta, L I, Gordon, M S, Tallman, J N, Winter, A M, Evens, A O, Evens, O, Frankfurt, S F, Williams, D, Grinblatt, L, Kaminer, R, Meagher, S, Singhal

Publikováno v: Bone marrow transplantation. 38(2)

Sixty three patients aged 27-66 years (median 52) were allografted from HLA-matched sibling (n=47), 10 of 10 allele-matched unrelated (n=19), or one-antigen/allele-mismatched (n=7) donors aged 24-69 years (median 46) after a conditioning regimen comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d0cd24c5c76fc605082727a7d07041
https://pubmed.ncbi.nlm.nih.gov/16751789

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Ideal rather than actual body weight should be used to calculate cell dose in allogeneic hematopoietic stem cell transplantation

Autor: S, Singhal, L I, Gordon, M S, Tallman, J N, Winter, A M, Evens, A O, Evens, O, Frankfurt, S F, Williams, D, Grinblatt, L, Kaminer, R, Meagher, J, Mehta

Publikováno v: Bone marrow transplantation. 37(6)

Whether the CD34+ and CD3+ cell doses in allogeneic HSCT should be estimated using actual (ABW) or ideal (IBW) body weight has never been definitively determined. We have shown that CD34+ cell doses based upon IBW are better predictive of engraftment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26e89dcb427f02fd386f9efa6697348
https://pubmed.ncbi.nlm.nih.gov/16444282

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Ideal or actual body weight to calculate CD34+ cell doses for autologous hematopoietic stem cell transplantation?

Autor: M Y Ali, Y Oyama, J Monreal, J N Winter, M S Tallman, S F Williams, S Singhal, L I Gordon, J Mehta

Publikováno v: Bone marrow transplantation. 31(10)

The number of CD34+ cells infused influences the speed of hematologic recovery post-transplant. There are limited data on whether ideal (IBW) or actual (ABW) body weight should be used to calculate CD34+ cell dose. We compared the correlation between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d401220f3a57ce0b60b8d90c6c62cd2c
https://pubmed.ncbi.nlm.nih.gov/12748662

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A phase II trial of 200% ProMACE-CytaBOM in patients with previously untreated aggressive lymphomas: analysis of response, toxicity, and dose intensity

Autor: L I, Gordon, M, Young, E, Weller, T M, Habermann, J N, Winter, J, Glick, C, Ghosh, P, Flynn, P A, Cassileth

Publikováno v: Blood. 94(10)

We showed in a phase I trial that the maximum tolerated dose of the ProMACE-CytaBOM regimen in patients with aggressive lymphoma was 200% (Gordon et al, J Clin Oncol 14:1275, 1996). Based on these observations, we initiated a phase II trial designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::500a78e8a8700a537828f950a2d66346
https://pubmed.ncbi.nlm.nih.gov/10552939

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