Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody

Autor: N. Stergiou, T. E. Wuensche, M. Schreurs, I. Mes, M. Verlaan, E. J. M. Kooijman, A. D. Windhorst, L. Helboe, S. Vergo, S. Christensen, A. A. Asuni, A. Jensen, G. A. M. S. Van Dongen, B. Bang-Andersen, D. J. Vugts, W. Beaino

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 50(5), 1306-1317. Springer Verlag
Stergiou, N, Wuensche, T E, Schreurs, M, Mes, I, Verlaan, M, Kooijman, E J M, Windhorst, A D, Helboe, L, Vergo, S, Christensen, S, Asuni, A A, Jensen, A, van Dongen, G A M S, Bang-Andersen, B, Vugts, D J & Beaino, W 2023, ' Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 5, pp. 1306-1317 . https://doi.org/10.1007/s00259-023-06109-3

Purpose The recent conditional FDA approval of Aducanumab (Adu) for treating Alzheimer’s disease (AD) and the continued discussions around that decision have increased interest in immunotherapy for AD and other brain diseases. Reliable techniques f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d269ebb8a676eb2d9dd830aa5a138c8
https://doi.org/10.1007/s00259-023-06109-3

Localisation of somatostatin and somatostatin receptors in benign and malignant ovarian tumours

Autor: Lindsay W. Turnbull, I Richmond, Stephen L. Atkin, L Helboe, Glen H. Hall

Publikováno v: British Journal of Cancer

Somatostatin has been identified as having anti-proliferative, anti-angiogenic and pro-apoptotic actions in many tumour systems, and these effects are mediated through a family of five transmembrane G-protein coupled SRIF receptors. Ovarian cancer is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132df939ae921e34af53553885b5591c
http://europepmc.org/articles/PMC2364287

Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation

Autor: M-L, Selenica, H S, Jensen, A K, Larsen, M L, Pedersen, L, Helboe, M, Leist, J, Lotharius

Background and purpose: Glycogen synthase kinase-3 (GSK-3) affects neuropathological events associated with Alzheimers disease (AD) such as hyperphosphorylation of the protein, tau. GSK-3beta expression, enzyme activity and tau phosphorylated at AD-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f8d46df30d6af7d581a084e20153fbe

The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas

Autor: D A Crooks, Nicholas D. Stafford, L T Condon, L Helboe, Stephen L. Atkin, M J C Rogers

Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584a2e5790f26832436249f3ca1a9bc9
https://europepmc.org/articles/PMC1770210/

Somatostatin receptor 2 expression in the human endometrium through the menstrual cycle

Autor: Victoria L, Green, I, Richmond, S, Maguiness, J, Robinson, L, Helboe, I P, Adams, N S, Drummond, S L, Atkin

Publikováno v: Clinical endocrinology. 56(5)

Somatostatin mediates its many inhibitory functions through five G-protein-coupled receptors (sstr1-5); however, it is not known whether somatostatin or its receptors are present in the endometrium.We have used immunohistochemistry on formalin-fixed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0026fe452cf4241b68c3f2aa2d973235
https://pubmed.ncbi.nlm.nih.gov/12030911