Zobrazeno 1 - 10
of 25
pro vyhledávání: '"L H Elliott"'
Publikováno v:
The Journal of Immunology. 159:4415-4425
It has been well established that patients with malignant glioblastomas exhibit T cell anergy. In this report, we further investigate the nature of this T cell anergy. The results demonstrate that tumor size but not location correlates with decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9711985ce97eb35c958d63264ae323
https://doi.org/10.4049/jimmunol.159.9.4415
https://doi.org/10.4049/jimmunol.159.9.4415
Autor:
J. Bishop, M. Brewster, J. M. Budd, David Bradshaw, F. Rose, Brown Paul Anthony, William Henry Johnson, K. M. K. Bottomley, Michael J. Broadhurst, K. Wilson, J. S. Nixon, B.M. Sutton, A. Greenham, L H Elliott, E. J. Lewis
Publikováno v:
British Journal of Pharmacology. 121:540-546
1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04ad879a10078b1561ba51fb5a1f8d7b
https://doi.org/10.1038/sj.bjp.0701150
https://doi.org/10.1038/sj.bjp.0701150
Autor:
Hans Werner Lahm, Pat Eyers, Brown Paul Anthony, Michael J. Broadhurst, L H Elliott, John M. Budd, Trevor J. Hallam, Urs Röthlisberger, David Bradshaw, Geoffrey Lawton, Amanda Whittle, J. S. Nixon, Maisie James, Hill Christopher Huw, Janet E. Merritt, Neera Borkakoti, William Henry Johnson, Balraj Krishnan Handa, K. M. K. Bottomley
Publikováno v:
Biochemical Journal. 323:483-488
N-terminal analysis of aggrecan fragments lost from bovine nasal cartilage cultured in the presence of recombinant human interleukin 1alpha revealed a predominant ARGSVIL sequence with an additional ADLEX sequence. Production of the ARGSVIL-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2481197cc0207f066b2fbffa6c53b86
https://doi.org/10.1042/bj3230483
https://doi.org/10.1042/bj3230483
Autor:
H. Kumar, J. Bishop, Hill Christopher Huw, D. Westmacott, Geoffrey Lawton, Peter D. Davis, J. S. Nixon, David Bradshaw, Sandra E. Wilkinson, L H Elliott, E. J. Lewis, MJ Mulqueen, J. Wadsworth
Publikováno v:
Biochemical Society Transactions. 20:419-425
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfcd3713cc7aeabc08a85853944537c
https://doi.org/10.1042/bst0200419
https://doi.org/10.1042/bst0200419
Autor:
Anthony D. Sedgwick, Peter D. Davis, L H Elliott, Geoffrey Lawton, J. S. Nixon, Sandra E. Wilkinson, Hill Christopher Huw
Publikováno v:
Biochemical and Biophysical Research Communications. 171:148-154
The inhibition of phosphorylase kinase by a number of protein kinase inhibitors was examined. Both K252a and staurosporine are potent inhibitors of phosphorylase kinase with IC50 values of 1.7 nM and 0.5 nM respectively. K252a shows a 300-fold select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0057ad08f12869bb037721e71211f0
https://doi.org/10.1016/0006-291x(90)91369-4
https://doi.org/10.1016/0006-291x(90)91369-4
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(9)
It has been well established that patients with malignant glioblastomas exhibit T cell anergy. In this report, we further investigate the nature of this T cell anergy. The results demonstrate that tumor size but not location correlates with decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f61d5d3d3811273b4435b1356aa32da
https://pubmed.ncbi.nlm.nih.gov/9379040
https://pubmed.ncbi.nlm.nih.gov/9379040
Autor:
A M, Birchall, J, Bishop, D, Bradshaw, A, Cline, J, Coffey, L H, Elliott, V M, Gibson, A, Greenham, T J, Hallam, W, Harris
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(2)
Several lines of circumstantial evidence support the assumption that protein kinase C (PKC) activation together with elevated levels of cytosolic Ca++ are necessary for T-cell activation and proliferation in response to a physiological stimulus, i.e.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ee2a26311fc7e321bd339c243d52461
https://pubmed.ncbi.nlm.nih.gov/8114006
https://pubmed.ncbi.nlm.nih.gov/8114006
Autor:
Elizabeth Keech, Harris William, M. K. Hari Kumar, John S. Nixon, L H Elliott, Steven A. Hurst, Sandra E. Wilkinson, Geoffrey Lawton, Hill Christopher Huw, Davis Peter David
Publikováno v:
Journal of medicinal chemistry. 35(6)
A hypothetical mode of inhibition of protein kinase C (PKC) by the natural product staurosporine has been used as a basis for the design of substituted bisindolylmaleimides with improved potency over the parent compound. Structure-activity relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1278979c3e06f4a53fd48df9a4ed1c
https://pubmed.ncbi.nlm.nih.gov/1552513
https://pubmed.ncbi.nlm.nih.gov/1552513
Autor:
J S, Nixon, J, Bishop, D, Bradshaw, P D, Davis, C H, Hill, L H, Elliott, H, Kumar, G, Lawton, E J, Lewis, M, Mulqueen
Publikováno v:
Drugs under experimental and clinical research. 17(8)
Clarification of the precise role of protein kinase C (PKC) in cellular functional responses has been hampered by a lack of potent, selective inhibitors. The structural lead provided by staurosporine, a potent but non-selective protein kinase (PK) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bebf7fae4f69dc40a2b10239e0f4656
https://pubmed.ncbi.nlm.nih.gov/1822831
https://pubmed.ncbi.nlm.nih.gov/1822831
Publikováno v:
Journal of Investigative Medicine. 52:S286.2-S286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a673202d5ce1d53b1ff241050ebab5da
https://doi.org/10.1136/jim-52-suppl1-716
https://doi.org/10.1136/jim-52-suppl1-716