Výsledky vyhledávání - "L H, Philipson"

Genome wide association studies for diabetes: perspective on results and challenges

Autor: J M, Torres, N J, Cox, L H, Philipson

Publikováno v: Pediatric diabetes. 14(2)

Recent results of genome wide association study (GWAS) for diabetes genes, while reaching impressive technical milestones and implicating new findings for research, have been uniformly disappointing in terms of immediate clinical utility. The relativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b79527f522a9bc94288caae7b8d5ca76
https://pubmed.ncbi.nlm.nih.gov/23350725

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TRP channels of the pancreatic beta cell

Autor: D A, Jacobson, L H, Philipson

Publikováno v: Handbook of experimental pharmacology. (179)

Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f948920c00f72f5e4f5d3baefcf5ba4
https://pubmed.ncbi.nlm.nih.gov/17217070

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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells

Autor: Christopher J. Rhodes, L H Philipson, J M Edwardson, B Wicksteed, J F McCuaig, Lori B. Hays, Y Wang

Publikováno v: The Journal of endocrinology. 185(1)

Several proteins play a role in the mechanism of insulin exocytosis. However, these ‘exocytotic proteins’ have yet to account for the regulated aspect of insulin exocytosis, and other factors are involved. In pancreatic exocrine cells, the intral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0a061949d09f48479869e769af6e1d
https://pubmed.ncbi.nlm.nih.gov/15817827

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beta-Agonists and metabolism

Autor: L H, Philipson

Publikováno v: The Journal of allergy and clinical immunology. 110

This review presents recent concepts of how beta-agonists affect glucose homeostasis by modulating insulin secretion, liver metabolism, and uptake of glucose into muscle, with attention to the influence of hypoglycemia on beta-agonist sensitivity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdc48fb8154acebe651dc6bbc7ed5579
https://pubmed.ncbi.nlm.nih.gov/12464941

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Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors

Autor: L, Sun, L H, Philipson, R J, Miller

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(2)

We examined the ability of rat Y1, Y2 and Y4 neuropeptide Y (NPY) receptors to regulate K+ and Ca++ channels expressed in Xenopus oocytes and HEK 293 cells, respectively. Stimulation of all three receptors with NPY or related peptides activated inwar

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https://pubmed.ncbi.nlm.nih.gov/9454807

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Akademický článek

Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5.

Autor: Ding, Lu¹ (AUTHOR), Sun, Yang¹ (AUTHOR), Liang, Yan¹ (AUTHOR), Zhang, Jie¹ (AUTHOR), Fu, Zhendong¹ (AUTHOR), Ren, Caiyue¹ (AUTHOR), Li, Pengfei² (AUTHOR), Liu, Wen¹ (AUTHOR), Xiao, Rong¹ (AUTHOR), Wang, Hao¹ (AUTHOR), Zhang, Zhaoying¹ (AUTHOR), Yue, Xuetian³ (AUTHOR), Li, Chunyang⁴ (AUTHOR), Wu, Zhuanchang¹ (AUTHOR), Feng, Yuemin⁵ (AUTHOR), Liang, Xiaohong¹ (AUTHOR), Ma, Chunhong¹ (AUTHOR), Gao, Lifen¹ (AUTHOR) glfflg@sdu.edu.cn

Publikováno v: Advanced Science. Apr2024, Vol. 11 Issue 16, p1-17. 17p.

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Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling

Autor: M W, Roe, J F, Worley, A A, Mittal, A, Kuznetsov, S, DasGupta, R J, Mertz, S M, Witherspoon, N, Blair, M E, Lancaster, M S, McIntyre, W R, Shehee, I D, Dukes, L H, Philipson

Publikováno v: The Journal of biological chemistry. 271(50)

Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles to these channels has proved problematic. Using transgenically derived insulinoma cells (bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::723326b060f01dedebfff1b11c2ad0bc
https://pubmed.ncbi.nlm.nih.gov/8943282

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Isoform expression of the voltage-dependent calcium channel alpha 1E

Autor: L M, Marubio, M, Röenfeld, S, Dasgupta, R J, Miller, L H, Philipson

Publikováno v: Receptorschannels. 4(4)

The alpha 1E voltage-dependent calcium channel has not been clearly identified with a specific neuronal calcium current. To help identify the role of alpha 1E, we examined differential expression of alpha 1E splice variants in mouse brain and culture

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https://pubmed.ncbi.nlm.nih.gov/9065972

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