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Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

Autor: R, Dajani, E, Fraser, S M, Roe, N, Young, V, Good, T C, Dale, L H, Pearl

Publikováno v: Cell. 105(6)

Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. The crystal structure of human GSK3 beta sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a0eb7a9ad2a29cd8ef757fd3d144b6a
https://pubmed.ncbi.nlm.nih.gov/11440715

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Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis

Autor: T H, Tan, S A, Edgerton, R, Kumari, M S, McAlister, S M, Roe, S, Nagl, L H, Pearl, M E, Selkirk, A E, Bianco, N F, Totty, C, Engwerda, C A, Gray, D J, Meyer, S M, Rowe

Publikováno v: The Biochemical journal. 357(Pt 2)

cDNAs were obtained for macrophage migration-inhibitory factor (MIF)/L-dopachrome methyl ester tautomerase homologues from the parasitic nematodes Trichinella spiralis (TsMIF) and Trichuris trichiura (TtMIF). The translated sequences, which were part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e2f1834dc8144be121f461712c3046e
https://pubmed.ncbi.nlm.nih.gov/11439086

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Molecular cloning and expression of the Fabs of human autoantibodies in Escherichia coli. Determination of the heavy or light chain contribution to the anti-DNA/-cardiolipin activity of the Fab

Autor: S, Kumar, J, Kalsi, C T, Ravirajan, A, Rahman, D, Athwal, D S, Latchman, D A, Isenberg, L H, Pearl

Publikováno v: The Journal of biological chemistry. 275(45)

The Fabs of three human autoantibodies (B3/33H11, anti-DNA; UK4, anti-phospholipid) and six related hybrids have been cloned, expressed in Escherichia coli, and purified to homogeneity. SDS-polyacrylamide gel electrophoresis and Western blot analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6114910d3e561d33be8ac5515a12363e
https://pubmed.ncbi.nlm.nih.gov/10893224

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Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

Autor: T E, Barrett, R, Savva, G, Panayotou, T, Barlow, T, Brown, J, Jiricny, L H, Pearl

Publikováno v: Cell. 92(1)

G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::046a3521630af2209c0070eb8c4d38c9
https://pubmed.ncbi.nlm.nih.gov/9489705

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Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein

Autor: D T, Jones, C M, Moody, J, Uppenbrink, J H, Viles, P M, Doyle, C J, Harris, L H, Pearl, P J, Sadler, J M, Thornton

Publikováno v: Proteins. 24(4)

In response to the Paracelsus Challenge (Rose and Creamer, Proteins, 19:1-3, 1994), we present here the design, synthesis, and characterization of a helical protein, whose sequence is 50% identical to that of an all-beta protein. The new sequence was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27a84d512500611c3fa6f1812fa6cc34
https://pubmed.ncbi.nlm.nih.gov/8859998

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X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin

Autor: T L, Blundell, J A, Jenkins, B T, Sewell, L H, Pearl, J B, Cooper, I J, Tickle, B, Veerapandian, S P, Wood

Publikováno v: Journal of molecular biology. 211(4)

The molecular structure of endothiapepsin (EC 3.4.23.6), the aspartic proteinase from Endothia parasitica, has been refined to a crystallographic R-factor of 0.178 at 2.1 A resolution. The positions of 2389 protein non-hydrogen atoms have been determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d064dd4416aee29957e4af3269b09c4
https://pubmed.ncbi.nlm.nih.gov/2179568

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Cleavage of RT/RNase H by HIV-1 Protease and Analysis of Substrate Cleavage Sites in vitro

Autor: L. Pavlitzkova, J. Kay, K.-H. Budt, T. Schulze, L. H. Pearl, M. Nawrath, K. Moelling, M. Souček, M.-T. Knoop, V. Kruft

Publikováno v: Retroviral Proteases ISBN: 9780333536124

The pol-gene of HIV-1 expressed in bacteria undergoes autocatalytic processing which results in the generation of the p66 reverse transcriptase (RT)/RN ase H, the p32 endonuclease and the p9 protease. The partially purified protease generates in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ed7d8b237ca3dc399dfec4a5d5e7192
https://doi.org/10.1007/978-1-349-11907-3_4

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Crystallographic studies of reduced bond inhibitors complexed with an aspartic proteinase

Autor: S. I. Foundling, J. Cooper, F. E. Watson, L. H. Pearl, A. Hemmings, S. P. Wood, T. Blundell, A. Hallett, D. M. Jones, J. Sueiras, B. Atrash, M. Szelke

Publikováno v: Journal of cardiovascular pharmacology. 10

To aid in the design of an effective inhibitor to human renin, it is essential to have a detailed knowledge of how this aspartic proteinase interacts with its substrate, angiotensinogen. Human renin shows a stringent specificity toward the Leu-Val bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c566ca055c88ba5344d7a00480c03567
https://pubmed.ncbi.nlm.nih.gov/2485065

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