Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation.

Autor: Zhang L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Liu W; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zheng Z; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China.; Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Zhang Q; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., He Y; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Gu J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Wang D; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Shu H; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Yu J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Liu J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Yin X; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zhang L; Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, 200245, China., Zhang J; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China.; Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., You Q; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Wang L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 24, pp. e202413618. Date of Electronic Publication: 2024 Nov 24.

Structure, function, and mechanism of the Hsp90 molecular chaperone

Autor: L H, Pearl, C, Prodromou

Publikováno v: Advances in protein chemistry. 59

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbd312f16049993fa15b41694a6da201
https://pubmed.ncbi.nlm.nih.gov/11868271

Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis

Autor: T H, Tan, S A, Edgerton, R, Kumari, M S, McAlister, S M, Roe, S, Nagl, L H, Pearl, M E, Selkirk, A E, Bianco, N F, Totty, C, Engwerda, C A, Gray, D J, Meyer, S M, Rowe

Publikováno v: The Biochemical journal. 357(Pt 2)

cDNAs were obtained for macrophage migration-inhibitory factor (MIF)/L-dopachrome methyl ester tautomerase homologues from the parasitic nematodes Trichinella spiralis (TsMIF) and Trichuris trichiura (TtMIF). The translated sequences, which were part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e2f1834dc8144be121f461712c3046e
https://pubmed.ncbi.nlm.nih.gov/11439086

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

Autor: T E, Barrett, R, Savva, G, Panayotou, T, Barlow, T, Brown, J, Jiricny, L H, Pearl

Publikováno v: Cell. 92(1)

G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::046a3521630af2209c0070eb8c4d38c9
https://pubmed.ncbi.nlm.nih.gov/9489705

Kinome‐Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma.

Autor: Vella, Viviana¹ (AUTHOR) vv62@sussex.ac.uk, Ditsiou, Angeliki¹ (AUTHOR), Chalari, Anna² (AUTHOR), Eravci, Murat¹ (AUTHOR), Wooller, Sarah K.³ (AUTHOR), Gagliano, Teresa⁴ (AUTHOR), Bani, Cecilia¹ (AUTHOR), Kerschbamer, Emanuela⁴ (AUTHOR), Karakostas, Christos² (AUTHOR), Xu, Bin⁵ (AUTHOR), Zhang, Yongchang⁶ (AUTHOR), Pearl, Frances M.G.³ (AUTHOR), Lopez, Gianluca^7,8 (AUTHOR), Peng, Ling⁹ (AUTHOR), Stebbing, Justin¹⁰ (AUTHOR), Klinakis, Apostolos² (AUTHOR), Giamas, Georgios¹ (AUTHOR) g.giamas@sussex.ac.uk

Publikováno v: Advanced Science. 4/17/2024, Vol. 11 Issue 15, p1-23. 23p.