Zobrazeno 1 - 10
of 31
pro vyhledávání: '"L H, Matherly"'
Publikováno v:
British Journal of Cancer
Confocal microscopy was used to visualize the intracellular uptake of the fluorescent methotrexate analogue, fluorescein-MTX (F-MTX), in human leukaemic cell lines and leukaemic blasts. Cytosolic labelling of wild-type K562 human erythroleukaemia cel
Publikováno v:
Advances in Down Syndrome Research ISBN: 9783211407769
Down syndrome (trisomy of chromosome 21) (DS) is the most common genetic cause of mental retardation. In our study we employed immunoblotting to evaluate protein expression of reduced folate carrier (hRFC), encoded by a gene localised on chromosome 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac4e620e0fe303f17625cdc2cbcd7d5
https://doi.org/10.1007/978-3-7091-6721-2_8
https://doi.org/10.1007/978-3-7091-6721-2_8
Autor:
L H, Matherly
Publikováno v:
Progress in nucleic acid research and molecular biology. 67
The natural folates are water-soluble members of the B class of vitamins that are essential for cell proliferation and tissue regeneration. Since mammalian cells cannot synthesize folates de novo, tightly regulated and sophisticated cellular uptake p
Autor:
X Y, Liu, L H, Matherly
Publikováno v:
The Biochemical journal. 358(Pt 2)
The human reduced folate carrier (hRFC) is an integral membrane protein that mediates cellular uptake of reduced folates and antifolates. hRFC contains several highly conserved charged residues predicted to lie in the transmembrane domains (TMDs). To
Publikováno v:
The Biochemical journal. 357(Pt 1)
Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine. Human CBS encodes five distinct 5' non-coding exons, the most frequent termed CBS -1a an
Autor:
S J, Shah, J W, Taub, T L, Witt, B H, Pollock, B C, Ding, D S, Moore, M, Amylon, J, Pullen, Y, Ravindranath, L H, Matherly
Publikováno v:
British journal of haematology. 113(3)
The downstream effects of p15 and p16 gene deletions and loss of transcripts on dihydrofolate reductase (DHFR) were examined in 63 B-precursor (BP) acute lymphoblastic leukaemia (ALL) samples. p15 and/or p16 gene deletions were seen in 6% and 8%, res
Autor:
J W, Taub, X, Huang, Y, Ge, J A, Dutcher, M L, Stout, R M, Mohammad, Y, Ravindranath, L H, Matherly
Publikováno v:
Cancer research. 60(22)
The significantly higher event-free survival rates of Down syndrome (DS) children with acute myeloid leukemia compared with non-DS children is linked to increased sensitivity of DS myeloblasts to 1-beta-D-arabinofuranosylcytosine (ara-C) and the enha
Autor:
J W, Taub, X, Huang, L H, Matherly, M L, Stout, S A, Buck, G V, Massey, D L, Becton, M N, Chang, H J, Weinstein, Y, Ravindranath
Publikováno v:
Blood. 94(4)
The high event-free survival rates of Down syndrome (DS) children with acute myeloid leukemia (AML) are due, in part, to increased in vitro sensitivity of DS myeloblasts to cytosine arabinoside (ara-C) and daunorubicin and the greater generation of a
Autor:
A J, Gifford, M, Kavallaris, J, Madafiglio, L H, Matherly, B W, Stewart, M, Haber, M D, Norris
Publikováno v:
International journal of cancer. 78(2)
We have previously described a series of methotrexate (MTX)-selected CCRF-CEM sublines (CEM/MTX R1-3) displaying increased resistance to drugs associated with the multidrug resistance phenotype and have provided evidence that MDR1 P-glycoprotein cont
Autor:
L, Zhang, J W, Taub, M, Williamson, S C, Wong, B, Hukku, J, Pullen, Y, Ravindranath, L H, Matherly
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(9)
Reduced folate carrier (RFC) transcripts in human leukemias were measured by a competitive PCR assay. Total RNAs were reverse transcribed and amplified in the presence of competitive templates for RFC and beta-actin. RFC transcripts were normalized t