Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization

Autor: Daniel E. Otzen, Troels Skrydstrup, Brian S. Vad, Claudia U. Hjørringgaard, Julie L. H. Madsen

Publikováno v: Madsen, J L H, Hjørringgaard, C U, Vad, B S, Otzen, D & Skrydstrup, T 2016, ' Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization ', Chemistry: A European Journal, vol. 22, no. 24, pp. 8358-8367 . https://doi.org/10.1002/chem.201600445

Incorporation of silicon-containing amino acids in peptides is known to endow the peptide with desirable properties such as improved proteolytic stability and increased lipophilicity. In the presented study, we demonstrate that incorporation of β-si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb980e156c3e508d8529b15f88e880c
https://doi.org/10.1002/chem.201600445

Access to 2,5-Diamidopyrroles and 2,5-Diamidofurans by Au(I)-Catalyzed Double Hydroamination or Hydration of 1,3-Diynes

Autor: Mario Rottländer, Troels Skrydstrup, Julie L. H. Madsen, Søren Kramer

Publikováno v: Kramer, S, Madsen, J L H, Rottländer, M & Skrydstrup, T 2010, ' Access to 2,5-diamidopyrroles and 2,5-diamidofurans by Au(I)-catalyzed double hydroamination or hydration of 1,3-diynes ', Organic Letters, vol. 12, no. 12, pp. 2758-2761 . https://doi.org/10.1021/ol1008685

A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes to access 2,5-diamidopyrroles and 2,5-diamidofurans has been developed. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles including the formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5671a14aaaab073444bc60fc7a63c221
https://doi.org/10.1021/ol1008685

Absence of cell-surface annexin V is accompanied by defective collagen matrix binding in the Swarm rat chondrosarcoma

Autor: K B, King, S, Chubinskaya, D L, Reid, L H, Madsen, J, Mollenhauer

Publikováno v: Journal of cellular biochemistry. 65(2)

Annexin V has been characterized as a major collagen type II binding cell-surface component of normal chondrocytes and is also called anchorin CII in chondrogenic populations. Herein we present evidence that in vitro cultured Swarm rat chondrosarcoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b28bd0a7c9b952055e639e3dd8c63e4d
https://pubmed.ncbi.nlm.nih.gov/9136073

[There is talk about gross throwing suspicion on without providing proof]

Autor: L H, Madsen

Publikováno v: Sygeplejersken. 86(18)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c7e3097e4ee66d88752df2c08ad62a7
https://pubmed.ncbi.nlm.nih.gov/3644538