Zobrazeno 1 - 4
of 4
pro vyhledávání: '"L H, Kondejewski"'
Publikováno v:
Journal of biomolecular NMR. 21(3)
The antimicrobial properties of the cyclic beta-sheet peptide gramicidin S are attributed to its destabilizing effect on lipid membranes. Here we present the membrane-bound structure and alignment of a derivative of this peptide, based on angular and
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 58(4)
As a step towards understanding the mechanism of the biological activity of cyclic antimicrobial peptides, the biophysical properties and conformations of four membrane-active cyclic peptide antibiotics, based on gramicidin S (GS), were examined in a
Publikováno v:
Methods in enzymology. 289
Publikováno v:
Bioconjugate chemistry. 5(6)
Efficacy of antibody mediated targeting depends on retention of immunoreactivity in conjugates. Retention can be improved by site-specific linkage of drugs or drug-loaded carriers to residues that are located well away from the antigen-binding sites.