Zobrazeno 1 - 10
of 712
pro vyhledávání: '"L Grogan"'
Autor:
Avantika S. Chitre, Ping Wu, Benjamin T. Walters, Xiangdan Wang, Alexandre Bouyssou, Xiangnan Du, Isabelle Lehoux, Rina Fong, Alisa Arata, Joyce Chan, Die Wang, Yvonne Franke, Jane L. Grogan, Ira Mellman, Laetitia Comps-Agrar, Weiru Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell receptor signaling and as such is an attractive target for cancer immunotherapy. Although the role of the HPK1 kinase domain (KD) has been extensively characterized,
Externí odkaz:
https://doaj.org/article/606ad94308a5488bb57edc5d41149491
Autor:
Robert J. Lentz, MD, Katherine Frederick-Dyer, MD, Virginia B. Planz, MD, Tatsuki Koyama, PhD, Matthew C. Aboudara, MD, Briana Swanner, BS, Lance Roller, MS, See-Wei Low, MD, Cristina Salmon, MD, Sameer K. Avasarala, MD, Todd C. Hoopman, MD, Momen M. Wahidi, MD, Kamran Mahmood, MD, MPH, George Z. Cheng, MD, PhD, James M. Katsis, MD, Jonathan S. Kurman, MD, Pierre-François D’Haese, PhD, Joyce Johnson, MD, Eric L. Grogan, MD, MPH, Charla Walston, AGACNP-BC, Lonny Yarmus, DO, Gerard A. Silvestri, MD, Otis B. Rickman, DO, Najib M. Rahman, DPhil, Fabien Maldonado, MD
Publikováno v:
CHEST Pulmonary, Vol 2, Iss 3, Pp 100050- (2024)
Background: Lung nodule incidence is increasing. Many nodules require biopsy to discriminate between benign and malignant causes. The gold standard for minimally invasive biopsy, CT scan-guided transthoracic needle biopsy (CT-TTNB), has not been comp
Externí odkaz:
https://doaj.org/article/898186340bd7445888d47d6e9038e66b
Autor:
Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, Kristen L. Seim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Jo
Externí odkaz:
https://doaj.org/article/620ea33bf16f4f77a76fcba73efa8992
Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness
Autor:
Georgii Vasiukov, Yong Zou, Maria-Fernanda Senosain, Jamshedur S. M. Rahman, Sanja Antic, Katherine M. Young, Eric L. Grogan, Michael N. Kammer, Fabien Maldonado, Cynthia A. Reinhart-King, Pierre P. Massion
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can i
Externí odkaz:
https://doaj.org/article/0aa600558c58426ca5beeb5b7def2354
Autor:
Daniel J. Craig, Erin L. Crawford, Heidi Chen, Eric L. Grogan, Steven A. Deppen, Thomas Morrison, Sanja L. Antic, Pierre P. Massion, James C. Willey
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective lung cancer screenin
Externí odkaz:
https://doaj.org/article/132d8247a9a24f2c96428fa8c097bbfb
Autor:
Rafael Paez, Michael N. Kammer, Aneri Balar, Dhairya A. Lakhani, Michael Knight, Dianna Rowe, David Xiao, Brent E. Heideman, Sanja L. Antic, Heidi Chen, Sheau-Chiann Chen, Tobias Peikert, Kim L. Sandler, Bennett A. Landman, Stephen A. Deppen, Eric L. Grogan, Fabien Maldonado
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract A deep learning model (LCP CNN) for the stratification of indeterminate pulmonary nodules (IPNs) demonstrated better discrimination than commonly used clinical prediction models. However, the LCP CNN score is based on a single timepoint that
Externí odkaz:
https://doaj.org/article/7b78666c04264aa586a2c11b09157b75
Autor:
Michael N. Kammer, PhD, Hidetoshi Mori, PhD, Dianna J. Rowe, BS, Sheau-Chiann Chen, PhD, Georgii Vasiukov, PhD, Thomas Atwater, MD, Maria Fernanda Senosain, PhD, Sanja Antic, MD, Yong Zou, MS, Heidi Chen, PhD, Tobias Peikert, MD, Steve Deppen, PhD, Eric L. Grogan, MD, Pierre P. Massion, MD, Steve Dubinett, MD, Marc Lenburg, PhD, Alexander Borowsky, MD, Fabien Maldonado, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 9, Pp 100504- (2023)
Introduction: Lung cancer is the deadliest cancer in the United States and worldwide, and lung adenocarcinoma (LUAD) is the most prevalent histologic subtype in the United States. LUAD exhibits a wide range of aggressiveness and risk of recurrence, b
Externí odkaz:
https://doaj.org/article/965e0718212541d0a561efc2131ac3f6
Autor:
Daniel R. Freno, MD, Maren E. Shipe, MD, MPH, Melissa M. Levack, MD, Ashish S. Shah, MD, Stephen A. Deppen, PhD, Jared M. O'Leary, MD, Eric L. Grogan, MD, MPH, FACS
Publikováno v:
JTCVS Open, Vol 7, Iss , Pp 63-71 (2021)
Objective: The aim of this study was to model the short term and 2-year overall survival (OS) for intermediate-risk and low-risk patients with severe symptomatic aortic stenosis (AS) undergoing timely or delayed transcatheter aortic valve replacement
Externí odkaz:
https://doaj.org/article/f18275e11858425d98dc15eb48917844
Autor:
Moore, Meredith L. Grogan, Kortlever, Joost T.P., Keulen, Mark H.F., Brigati, David P., Bozic, Kevin J., Koenig, Karl M.
Publikováno v:
In Journal of Orthopaedics September-October 2020 21:58-61
Autor:
Rafael Paez, Chirayu Shah, Angelina J. Cords, Anel Muterspaugh, John E. Helton, Sanja Antic, Rosana Eisenberg, Heidi Chen, Eric L. Grogan, Henry C. Manning, Ronald C. Walker, Pierre P. Massion
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Background 18F-fluorodeoxyglucose (FDG) PET/CT is recommended for evaluation of intermediate-risk indeterminate pulmonary nodules (IPNs). While highly sensitive, the specificity of FDG remains suboptimal for differentiating malignant from benign nodu
Externí odkaz:
https://doaj.org/article/4a8fe88963fd4a9da8bcb3f6593e791a