Zobrazeno 1 - 10
of 80
pro vyhledávání: '"L Gradoville"'
Autor:
L Gradoville, J. Countryman, Lee Heston, George Miller, Jianjiang Ye, Sarah Himmelfarb, Sumita Bhaduri-McIntosh, Duane Shedd
Publikováno v:
Journal of Virology. 83:10694-10709
Epstein-Barr virus (EBV) can be reactivated from latency into the lytic cycle by many stimuli believed to operate by different mechanisms. Cell lines containing EBV differ in their responses to inducing stimuli, yet all stimuli require de novo protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97be862d25d9b7643bfaa11d4b87c84e
https://doi.org/10.1128/jvi.01172-09
https://doi.org/10.1128/jvi.01172-09
Publikováno v:
Journal of Virology. 81:9279-9291
The oncogenic human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are latent in cultured lymphoma cells. We asked whether reactivation from latency of either virus requires de novo protein synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012784b727d4a35f5935646d010b659e
https://doi.org/10.1128/jvi.00982-07
https://doi.org/10.1128/jvi.00982-07
Publikováno v:
Journal of Virology. 76:5612-5626
The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a PKC agonist, is one of the best understood activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ca60818b30c3ed8a21035c6103abc4
https://doi.org/10.1128/jvi.76.11.5612-5626.2002
https://doi.org/10.1128/jvi.76.11.5612-5626.2002
Publikováno v:
Proceedings of the National Academy of Sciences. 95:10866-10871
Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e78289a6d31d2db6b35adc7380b19
https://doi.org/10.1073/pnas.95.18.10866
https://doi.org/10.1073/pnas.95.18.10866
Publikováno v:
Journal of Virology. 71:3054-3061
The ZEBRA protein from Epstein-Barr virus (EBV) activates a switch from the latent to the lytic expression program of the virus. ZEBRA, a member of the bZIP family of DNA-binding proteins, is a transcriptional activator capable of inducing expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3619f9e70a79393e87d9677878bc83e9
https://doi.org/10.1128/jvi.71.4.3054-3061.1997
https://doi.org/10.1128/jvi.71.4.3054-3061.1997
Publikováno v:
Journal of Virology. 70:1493-1504
The lytic cycle of Epstein-Barr virus (EBV) can be activated by transfection of the gene for ZEBRA, a viral basic-zipper (bZip) transcriptional activator. ZEBRA and cellular AP-1 bZip activators, such as c-Fos, have homologous DNA-binding domains, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d233625b46e688846d8b49de88034896
https://doi.org/10.1128/jvi.70.3.1493-1504.1996
https://doi.org/10.1128/jvi.70.3.1493-1504.1996
Publikováno v:
Journal of virology. 84(23)
The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b04867c5eab2324f50d8a567c0428e
https://pubmed.ncbi.nlm.nih.gov/20861250
https://pubmed.ncbi.nlm.nih.gov/20861250
Publikováno v:
Journal of virology. 82(10)
Activation of the Epstein-Barr virus (EBV) lytic cycle is mediated through the combined actions of ZEBRA and Rta, the products of the viral BZLF1 and BRLF1 genes. During latency, these two genes are tightly repressed. Histone deacetylase inhibitors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db47c82e86096088843d732a916bf5d
https://pubmed.ncbi.nlm.nih.gov/18337569
https://pubmed.ncbi.nlm.nih.gov/18337569
Autor:
Craig Metroka, Duane Shedd, L Gradoville, Sarah Nikiforow, Elizabeth Grogan, George Miller, Jennifer Gerlach
Rta, the gene product of Kaposi's sarcoma-associated herpesvirus (KSHV) encoded mainly in open reading frame 50 (ORF50), is capable of activating expression of viral lytic cycle genes. What was not demonstrated in previous studies was whether KSHV Rt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79511a719258e0cd82f3513a7f97263e
https://europepmc.org/articles/PMC112123/
https://europepmc.org/articles/PMC112123/
Autor:
Ren Sun, George Miller, L Gradoville, Elizabeth Grogan, Katherine Staskus, Su-Fang Lin, Ashley T. Haase
Herpesvirus gene expression can be classified into four distinct kinetic stages: latent, immediate early, early, and late. Here we characterize the kinetic class of a group of 16 Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a8854c8e433552d9ffda1b57627577
https://europepmc.org/articles/PMC104468/
https://europepmc.org/articles/PMC104468/