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Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study1 1The other PROACTIVE Study Group investigators included the following: Vijayan Balan, M.D., Mayo Clinic Scottsdale, Scottsdale, Arizona; Norbert Bräu, M.D., Bronx VA Medical Center, Bronx, New York; Robert Brown, M.D., M.P.H., NY Presbyterian Medical Center, New York, New York; William Carey, M.D., Cleveland Clinic Foundation, Cleveland, Ohio; Andrea Duchini, M.D., Baylor College of Medicine, Houston, Texas; Greg Everson, M.D., University of Colorado Health Sciences Center, Denver, Colorado; Michael Fried, M.D., University of North Carolina, Chapel Hill, North Carolina; Robert Gish, M.D., California Pacific Medical Center, San Francisco, California; Ira Jacobson, M.D., Weill Medical College of Cornell University, New York, New York; John W. King, LSU Health Sciences Center, Shreveport, LA; Raymond Koff, M.D., University of Massachusetts Memorial Health Care, Worcester, Massachusetts; William Lee, M.D., University of Texas Southwestern Medical Center, Dallas, Texas; Mark A. Levstik, M.D., The University of Tennessee, Memphis, Tennessee; John G. McHutchison, M.D., Scripps Clinic, La Jolla, California; Marion Peters, M.D., University of California San Francisco, San Francisco, California; Kenneth Sherman, M.D., Ph.D., University of Cincinnati College of Medicine, Cincinnati, Ohio; Coleman Smith, M.D., Minnesota Clinical Research Center, St. Paul, MN; Ronald Wasserman, M.D., Hepatitis Resource Center, Walnut Creek, California

Autor: Mitchell L. Shiffman, Mark S. Sulkowski, Zobair M. Younossi, Paul J. Pockros, Eugene R. Schiff, Peter J. Bowers, Betty L. Goon, Douglas T. Dieterich, Nezam H. Afdhal, K. Linda Tang, Teresa L. Wright

Publikováno v: Gastroenterology. 126:1302-1311

Background & Aims: Combination therapy with interferon α (IFN-α) and ribavirin (RBV) or pegylated IFN-α (PEG-IFN-α)/RBV for chronic hepatitis C virus (HCV) infection often causes anemia, prompting RBV dose reduction/discontinuation. This study as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71e7b0ebf629de21132180cdc98cfc3b
https://doi.org/10.1053/j.gastro.2004.01.027

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Cell volume response to hyposmotic shock and elevated cAMP in bovine trabecular meshwork cells

Autor: M. Satpathy, Beatrice Y.J.T. Yue, L H Goon, Sangly P. Srinivas, Guillaume Droogmans, L Goon, Bernd Nilius, Chantal Maertens

Publikováno v: Experimental Eye Research. 78:15-26

Purpose . Hyposmolar perfusion of intact trabecular meshwork (TM) induces a decrease in its hydraulic conductivity (Lp). However, exposure to agents that elevate intracellular cAMP in TM cells increases Lp. Since volume of TM cells could directly inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6656753aee6082defaafb8572918670d
https://doi.org/10.1016/j.exer.2003.10.001

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Erythropoietic response to anemia in chronic hepatitis C patients receiving combination pegylated interferon/ribavirin

Autor: Peter J. Bowers, Vijayan Balan, Betty L. Goon, Reem Ghalib, Andrew J. Muir, A. Burnett, David E. Schwartz, John Jackson, George Y Wu, Gerhard Leitz, Emmet B. Keeffe, Lorenzo Rossaro

Publikováno v: The American journal of gastroenterology. 100(2)

In hepatitis C virus (HCV)-infected patients receiving pegylated interferon (PEG-IFN)/ribavirin (RBV) combination therapy, anemia is a well-known side effect. The purpose of this study was to describe the time course and extent of hemoglobin (Hb) cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237ebee985684d5108b861b7922f50e8
https://pubmed.ncbi.nlm.nih.gov/15667486

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Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy

Autor: Teresa L. Wright, Eugene R. Schiff, Gerhard Leitz, Mitchell L. Shiffman, Zobair M. Younossi, Betty L. Goon, Nezam H. Afdhal, Paul J. Pockros, Mark S. Sulkowski, K. Linda Tang, Samir H. Mody, Douglas T. Dieterich, Peter J. Bowers

Publikováno v: Hepatology (Baltimore, Md.). 40(6)

Anemia and decreased health-related quality of life (HRQL) are common in patients receiving combination therapy of interferon alfa (IFN) and ribavirin (RBV) for chronic hepatitis C virus (HCV) infection. In a randomized, prospective study evaluating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7820f26ad1a8ab9fe3c74c3d0dcc9aa3
https://pubmed.ncbi.nlm.nih.gov/15565613

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Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study

Autor: Nezam H, Afdhal, Douglas T, Dieterich, Paul J, Pockros, Eugene R, Schiff, Mitchell L, Shiffman, Mark S, Sulkowski, Teresa, Wright, Zobair, Younossi, Betty L, Goon, K Linda, Tang, Peter J, Bowers

Publikováno v: Gastroenterology. 126(5)

Combination therapy with interferon alpha (IFN-alpha) and ribavirin (RBV) or pegylated IFN-alpha (PEG-IFN-alpha)/RBV for chronic hepatitis C virus (HCV) infection often causes anemia, prompting RBV dose reduction/discontinuation. This study assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4b6b0c98c3c265ba6169276bf3e9b55
https://pubmed.ncbi.nlm.nih.gov/16265040

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Data mining ocean model output at the Naval Oceanographic Office Shared Resource Center

Autor: P. Gruzinskas, L. Goon, A. Haas

Publikováno v: Oceans '02 MTS/IEEE.

One of the computational technology areas supported by the High Performance Computing Modernization Program is Climate, Weather, and Ocean (CWO) modeling. To this end, state-of-art computing architectures are leveraged against the extremely difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed846d9b922a952141a3e4fc2e20a77c
https://doi.org/10.1109/oceans.2002.1192064

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Akademický článek

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Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin after single and multiple subcutaneous doses to healthy subjects

Autor: Mary C. Wacholtz, Mary C. Guilfoyle, Betty L. Goon, Wing K. Cheung

Publikováno v: Clinical pharmacology and therapeutics. 64(4)

Objectives To understand the pharmacokinetic and pharmacodynamic properties of recombinant human erythropoietin (epoetin alfa) and to continue to optimize dosing regimens by determining whether administration of single high doses of epoetin alfa is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e7cc3e3bd3ef572b2279a02135354d
https://pubmed.ncbi.nlm.nih.gov/9797798

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