ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function.

Autor: Huijing Xia, Sonia Suda, Sharell Bindom, Yumei Feng, Susan B Gurley, Dale Seth, L Gabriel Navar, Eric Lazartigues

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22682 (2011)

Oxidative stress in the central nervous system mediates the increase in sympathetic tone that precedes the development of hypertension. We hypothesized that by transforming Angiotensin-II (AngII) into Ang-(1-7), ACE2 might reduce AngII-mediated oxida

Externí odkaz: https://doaj.org/article/9b1bf537bb3d4e0b96a8ec1db06802fd

High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney

Autor: Dewan S. A. Majid, Alexander Castillo, Minolfa C. Prieto, L. Gabriel Navar

Publikováno v: Exploration of Medicine. :205-218

Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism of this augmentation is not clearly understood. As tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de4e07513471feaa4dc344534bb05bd4
https://doi.org/10.37349/emed.2022.00086

Immunosuppression by Mycophenolate Mofetil Mitigates Intrarenal Angiotensinogen Augmentation in Angiotensin II-Dependent Hypertension

Autor: Ryousuke Satou, Martha Franco, Courtney M. Dugas, Akemi Katsurada, L. Gabriel Navar

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7680

Augmentation of intrarenal angiotensinogen (AGT) leads to further formation of intrarenal angiotensin II (Ang II) and the development of hypertensive kidney injury. Recent studies demonstrated that macrophages and the enhanced production of pro-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aac069d80a818dd3870b1d4cbca6776
https://pubmed.ncbi.nlm.nih.gov/35887028

Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure

Autor: Antoine H. Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L. Gabriel Navar, David Busija, Patrice Delafontaine

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 235
International Journal of Molecular Sciences, Vol 23, Iss 235, p 235 (2022)

Metabolic remodeling plays an important role in the pathophysiology of heart failure (HF). We sought to characterize metabolic remodeling and implicated signaling pathways in two rat models of early systolic dysfunction (MOD), and overt systolic HF (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fe04aecae53156f927c8c4eb56f5e
http://europepmc.org/articles/PMC8745344

Integration of purinergic and angiotensin II receptor function in renal vascular responses and renal injury in angiotensin II-dependent hypertension

Autor: Martha Franco, Oscar Pérez-Méndez, L. Gabriel Navar, Supaporn Kulthinee

Publikováno v: Purinergic Signalling. 15:277-285

Glomerular arteriolar vasoconstriction and tubulointerstitial injury are observed before glomerular damage occurs in models of hypertension. High interstitial ATP concentrations, caused by the increase in arterial pressure, alter renal mechanisms inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c05c98df7e7e9ed848a9044a67b615b
https://doi.org/10.1007/s11302-019-09662-5