Psychological distress and trauma in doctors providing frontline care during the COVID-19 pandemic in the United Kingdom and Ireland: a prospective longitudinal survey cohort study

Autor: Daniel Horner, Jo Daniels, Charles Reynard, James Foley, Blair Graham, Mark David Lyttle, M Anderson, J Browning, M Clark, S Foster, S Hartshorn, M Jacobs, S Messahel, N Mullen, J Brown, Michael Barrett, S Subramaniam, S Williams, A Ahmed, E Williams, S Hall, Edward Carlton, C Bi, M Khan, R Hannah, S Taylor, L Dunlop, J Gumley, K Knight, C Williams, J Turner, B Taylor, R Mills, M Lim, J Evans, C O’Connell, Tom Roberts, A Rai, P Singh, M Williams, S Graham, Etimbuk Umana, R Taylor, S Rahman, J Wright, J Lynch, S Lewis, P Fitzpatrick, J Ng, V Talwar, N Ali, G Pells, P Ellis, J Bailey, John Cronin, J Morgan, K Samuel, A Ali, M Patel, R Evans, S Morgan, A Hill, S Rao, S Currie, C Thomas, K Thomas, William Hulme, Katie Samuel, Robert Hirst, H Cooper, L McKechnie, S Pradhan, A Brookes, W Niven, L Kane, C Rimmer, K Kaur, R Stewart, T Hussan, P Cuthbert, M Alex, F Barham, R Macfarlane, M Jee Poh Hock, C Ward, C Weegenaar, O Williams, S Manou, MH Elwan, C Nunn, C Reynard, L How, D McConnell, J Muller, H Malik, K Challen, C Magee, S Pintus, S Langston, C Szekeres, L Kehler, C Leech, Y Moulds, A Mackay, R Wright, A Saunders, S Naeem, N Cherian, C Boulind, L Brown, E Grocholski, A Tabner, M Colmar, D Raffo, L Somerset, C Holmes, L Armstrong, S Collins, J Lowe, J Ritchie, F Wood, M Mohammad, S Wilson, R O'Sullivan, R Ellis, M MacKenzie, B Johnson, R Das, L Robinson, P Turton, L Robertson, A Robertson, J Hunt, João Vinagre, H Millar, R Freeman, A Corfield, R McQuillan, A Hormis, L Mackenzie, S Sharma Hajela, J Phizacklea, J Maney, K Malik, D Metcalfe, N Mathai, S Timmis, A Sattout, R Newport, E Fadden, D Bawden, B O'Hare, C Roe, D Bewick, F Taylor, L Barnicott, A Charlton, L McCrae, C Munday, E Godden, A Turner, R Sainsbury, A Lawrence-Ball, R House, S Patil, I Skene, M Winstanley, N Tambe, D Mawhinney, M Elkanzi, T Perry, W Kan, M Cheema, A Clarey, R Greenhalgh, A Gulati, S Marimuthu, K Webster, A Howson, R Doonan, B Shrestha, L Stanley, A Trimble, E Colley, J Lockwood, T Mohamed, H Jarman, S Ramraj, V Worsnop, N Masood, R McLatchie, A Peasley, S Bongale, U Bait, S Nagendran, A Hay, F Mendes, H Raybould, T Baron, C Ponmani, M Depante, R Sneep, Z Al-Janabi, A Rainey, N Marriage, B Mallon, J McLaren, S Hart, M Elsheikh, L Cocker, S Keers, K L Vincent, D Craver, N Sarja, N Moultrie, M Viegas, S Purvis, E Wooffinden, C Davies, S Foreman, A Da-Costa, C Ngua, S Duckitt, N Hoskins, J Fryer, T Hine, F Ihsan, L Frost, H Abdullah, K Bader, K Gray, M Manoharan, R Muswell, P Amiri, M Bonsano, S Shrivastava, F Raza, E Christmas, M Riyat, L O'Rourke, H Knott, K Adeboye, M Ramazany, K Iftikhar, N Abela, R Darke, D Maasdorp, H Murphy, H Edmundson, c Orjioke, L Harwood, D Worley, K Lines, W Collier, J Everson, D Ranasinghe, N Maleki, A Stafford, S Gokani, M Charalambos, A Olajide, H Ahmad, K Holzman, A Patton, S Gilmartin, S Uí Bhroin, S Kukaswadia, C Prendergast, C Dalla Vecchia, M Grummell, I Grossi, B MacManus, A Boyle, A Waite, J Vinagre, D George, C Battle, J Anandarajah, I Hancock, D Manthalapo, Ramesh Babu, FM Burton, I Musliam, Veettil Asif, M JeePoh Hock

Publikováno v: BMJ Open, Vol 11, Iss 7 (2021)

Objectives The psychological impact of the COVID-19 pandemic on doctors is a significant concern. Due to the emergence of multiple pandemic waves, longitudinal data on the impact of COVID-19 are vital to ensure an adequate psychological care response

Externí odkaz: https://doaj.org/article/8bb128d7ad9a43de9f2244ace53ef9c0

Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

Autor: Sachindra R. Joshi, Jun Liu, Troy Bloom, Elif Karaca Atabay, Tzu-Hsing Kuo, Michael Lee, Elitza Belcheva, Matthew Spaits, Rosa Grenha, Michelle C. Maguire, Jeffrey L. Frost, Kathryn Wang, Steven D. Briscoe, Mark J. Alexander, Brantley R. Herrin, Roselyne Castonguay, R. Scott Pearsall, Patrick Andre, Paul B. Yu, Ravindra Kumar, Gang Li

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Abstract Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. How

Externí odkaz: https://doaj.org/article/30b6e26c2ac54524a92a73737016bed3

[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Autor: Tanuj Puri, Michelle L. Frost, Gary J. Cook, Glen M. Blake

Publikováno v: Tomography, Vol 7, Iss 4, Pp 843-854 (2021)

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to unders

Externí odkaz: https://doaj.org/article/2f527499b604496db5460efe1600a9c9

Neurons and Astrocytes Elicit Brain Region Specific Transcriptional Responses to Prion Disease in the Murine CA1 and Thalamus

Autor: Jessy A. Slota, Sarah J. Medina, Kathy L. Frost, Stephanie A. Booth

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Progressive dysfunction and loss of neurons ultimately culminates in the symptoms and eventual fatality of prion disease, yet the pathways and mechanisms that lead to neuronal degeneration remain elusive. Here, we used RNAseq to profile transcription

Externí odkaz: https://doaj.org/article/b93e609511584e249384707caaf117e3

Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease

Autor: Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham, Robert Vendramelli, Yanlong Pei, Nikesh Tailor, Emelissa Valcourt, Anders Leung, Shihua He, Bryan D. Griffin, Jonathan Audet, Marnie Willman, Kevin Tierney, Alixandra Albietz, Kathy L. Frost, Jacob G.E. Yates, Robert C. Mould, Lily Chan, Yeganeh Mehrani, Jason P. Knapp, Jessica A. Minott, Logan Banadyga, David Safronetz, Heidi Wood, Stephanie Booth, Pierre P. Major, Byram W. Bridle, Leonardo Susta, Darwyn Kobasa, Sarah K. Wootton

Publikováno v: iScience, Vol 24, Iss 11, Pp 103219- (2021)

Summary: The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newc

Externí odkaz: https://doaj.org/article/a9d6cd355eb7470ba0489696155667f5