Zobrazeno 1 - 10
of 240
pro vyhledávání: '"L Fok"'
Autor:
Dharaminder Singh, Sudhir P Deosarkar, Elaine Cadogan, Vikki Flemington, Alysha Bray, Jingwen Zhang, Ronald S Reiserer, David K Schaffer, Gregory B Gerken, Clayton M Britt, Erik M Werner, Francis D Gibbons, Tomasz Kostrzewski, Christopher E Chambers, Emma J Davies, Antonio Ramos Montoya, Jacqueline H L Fok, David Hughes, Kristin Fabre, Matthew P Wagoner, John P Wikswo, Clay W Scott
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001624 (2022)
Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly replicates the pharmacokinetic (PK) concentration changes seen in vivo and reduces the predictiv
Externí odkaz:
https://doaj.org/article/55008e3ff350462b806cde78444e0ef3
Autor:
Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies, Elaine B. Cadogan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibit
Externí odkaz:
https://doaj.org/article/7547983126794fc0a17cf1c4d462a298
Akademický článek
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Publikováno v:
International Endodontic Journal. 55:1091-1102
The use of high-concentration sodium hypochlorite (NaOCl) as an endodontic irrigant remains controversial because of its potential impact on the fracture strength of endodontically treated teeth. This study evaluated the effects of using different Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4735d65bd6f3bbcf44acb9c13125e43
https://doi.org/10.1111/iej.13800
https://doi.org/10.1111/iej.13800
Publikováno v:
Journal of Endocrinological Investigation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cd14bfe943bca6069abe30925fed1f9
https://doi.org/10.1007/s40618-023-02055-x
https://doi.org/10.1007/s40618-023-02055-x
Publikováno v:
Dent Mater
OBJECTIVE: To investigate the fatigue behavior of restored teeth, in particular the mechanisms of longitudinal dentinal cracking under cyclic mechanical loading, using finite element analysis (FEA) and the stress-life (S-N) approach. METHODS: Ten roo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d376b0fc66bd4b667a59db558cb79a6
https://doi.org/10.1016/j.dental.2021.12.005
https://doi.org/10.1016/j.dental.2021.12.005
Publikováno v:
J Dent Res
Due to the severe mechano-biochemical conditions in the oral cavity, many dental restorations will degrade and eventually fail. For teeth restored with resin composite, the major modes of failure are secondary caries and fracture of the tooth or rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66874a212fd66af035e2aee5dd6f126
https://doi.org/10.1177/00220345211026918
https://doi.org/10.1177/00220345211026918
Autor:
Alan Lau, Susan Galbraith, Sonja J. Gill, Mark J. O'Connor, Joshua Armenia, Jacqueline H. L. Fok, Conchita Vens, Rebecca L. Lloyd, Jonathan Cairns, Jenni Nikkilä, Christopher J. Bakkenist, Paul W. G. Wijnhoven
Publikováno v:
Mol Cancer Ther
Radiotherapy is an effective anticancer treatment, but combinations with targeted agents that maximize efficacy while sparing normal tissue are needed. Here, we assess the radiopotentiation profiles of DNA damage response inhibitors (DDRi) olaparib (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633fe37e32a0d72b0b66bc4989529109
https://doi.org/10.1158/1535-7163.mct-20-0502
https://doi.org/10.1158/1535-7163.mct-20-0502
Akademický článek
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Akademický článek
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