Výsledky vyhledávání - "L Fernando Santana"

Akademický článek

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

Autor: Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer, Pei-Chi Yang, Collin Matsumoto, Mindy Tieu, Zhihui Fong, Timothy J Lewis, L Fernando Santana, Colleen E Clancy

Publikováno v: eLife, Vol 12 (2024)

The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the ‘Her

Externí odkaz: https://doaj.org/article/e1c78cfe649246afb454472a4d6e05a3

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Akademický článek

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

Autor: Nicholas C Vierra, Michael Kirmiz, Deborah van der List, L Fernando Santana, James S Trimmer

Publikováno v: eLife, Vol 8 (2019)

The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (

Externí odkaz: https://doaj.org/article/3aac78b407d745ab9efca99cb8492d78

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Akademický článek

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

Autor: Jie-Xian Dong, Yongam Lee, Michael Kirmiz, Stephanie Palacio, Camelia Dumitras, Claudia M Moreno, Richard Sando, L Fernando Santana, Thomas C Südhof, Belvin Gong, Karl D Murray, James S Trimmer

Publikováno v: eLife, Vol 8 (2019)

Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies t

Externí odkaz: https://doaj.org/article/13ea854aadef4d35bafff7c930066b21

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Akademický článek

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

Autor: Heidi Hehnly, David Canton, Paula Bucko, Lorene K Langeberg, Leah Ogier, Irwin Gelman, L Fernando Santana, Linda Wordeman, John D Scott

Publikováno v: eLife, Vol 4 (2015)

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12

Externí odkaz: https://doaj.org/article/7a011613427d4eeaae2a859ad312900d

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Akademický článek

Regulating voltage-gated ion channels with nanobodies

Autor: Declan Manning, L. Fernando Santana

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)

In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca2+ channels associated with β1 subunits and promote their removal from the surface membrane of neurons a

Externí odkaz: https://doaj.org/article/20f08bab69cd4a8b9cc0b34499213acf

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Mechanisms and physiological implications of cooperative gating of clustered ion channels

Autor: Rose E. Dixon, Manuel F. Navedo, Marc D. Binder, L. Fernando Santana

Publikováno v: Physiol Rev

Ion channels play a central role in the regulation of nearly every cellular process. Dating back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion channels have always been thought of as independent agents. A m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdaec94a95f3c27d73a951ccc9fe162
https://pubmed.ncbi.nlm.nih.gov/34927454

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