Mouse models in the era of large human tumour sequencing studies

Autor: J. R. de Ruiter, L. F. A. Wessels, J. Jonkers

Publikováno v: Open Biology, Vol 8, Iss 8 (2018)

Cancer is a complex disease in which cells progressively accumulate mutations disrupting their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour suppressor genes, but many mutations are passengers

Externí odkaz: https://doaj.org/article/e2ee2d21a73a49ceb0f3858c483add14

Author response for 'Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases'

Autor: Srinivasan Yegnasubramanian, Matthew L. Freedman, Angelo M. De Marzo, Andries M. Bergman, Yanyun Zhu, Michael C. Haffner, Wilbert Zwart, Jonathan W. Simons, L. F. A. Wessels, Tracy Jones, Tesa M. Severson, William G. Nelson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d1be595681131bd3f374f40ee08d3b0
https://doi.org/10.1002/1878-0261.12923/v2/response1

Integrative epigenetic taxonomy of primary prostate cancer

Autor: Andries M. Bergman, Eider Valle-Encinas, Seiwon Laura Chang, Karianne Schuurman, João Lobo, Rui Henrique, Felix Y. Feng, Carmen Jerónimo, Suzan Stelloo, Wilbert Zwart, Ekaterina Nevedomskaya, Oscar Krijgsman, Daniel S. Peeper, L. F. A. Wessels, Yongsoo Kim

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, 9(1):4900. Nature Publishing Group UK
Nature Communications, 9(1)
Nature Communications, 9(1):4900. Nature Publishing Group
Nature Communications
Stelloo, S, Nevedomskaya, E, Kim, Y, Schuurman, K, Valle-Encinas, E, Lobo, J, Krijgsman, O, Peeper, D S, Chang, S L, Feng, F Y C, Wessels, L F A, Henrique, R, Jerónimo, C, Bergman, A M & Zwart, W 2018, ' Integrative epigenetic taxonomy of primary prostate cancer ', Nature Communications, vol. 9, no. 1, 4900 . https://doi.org/10.1038/s41467-018-07270-2

The Androgen Receptor (AR) is the key-driving transcription factor in prostate cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has been performed in cell lines or limited tissue samples. Here, to comprehensivel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58706f4a309a0d63b3615133ef24ae38
http://link.springer.com/article/10.1038/s41467-018-07270-2

82O Genomic evolution of metastatic tumours under therapeutic pressure

Autor: Emile E. Voest, L.R. Hoes, L. F. A. Wessels, J. van de Haar, Edwin Cuppen, Paul Roepman

Publikováno v: Annals of Oncology. 31:S274

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5452791a7bd161117f9f2c15f8cef8d5
https://doi.org/10.1016/j.annonc.2020.08.203

Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis

Autor: Liesbeth Hoekman, T Mirza, Onno B. Bleijerveld, Wilbert Zwart, L. F. A. Wessels, Suzan Stelloo, Yongsoo Kim, W.M. van Weerden, Andries M. Bergman, A F M Altelaar, Ekaterina Nevedomskaya

Publikováno v: Oncogene, 37(3), 313-322. Nature Publishing Group
Stelloo, S, Nevedomskaya, E, Kim, Y, Hoekman, L, Bleijerveld, O B, Mirza, T, Wessels, L F A, Van Weerden, W M, Altelaar, A F M, Bergman, A M & Zwart, W 2018, ' Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis ', Oncogene, vol. 37, no. 3, pp. 313-322 . https://doi.org/10.1038/onc.2017.330
Oncogene, 37. Nature Publishing Group

Androgen receptor (AR) is a key player in prostate cancer development and progression. Here we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to identify components of the AR transcriptional complex. In total, 66 known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2429f5480396141ca15ad7224d72aa2
https://dspace.library.uu.nl/handle/1874/428130