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Determination and confirmation of selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors in bovine and porcine urine using UHPLC-MS/MS

Autor: Georgios Kaklamanos, Leendert A. van Ginkel, Saskia S. Sterk, Thijs Meijer, Martien L. Essers

Publikováno v: Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment 34 (2017) 4
Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 34(4), 641-651

Selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors are prohibited in human sports doping. However, they also present a risk of being used illegally in animal husbandry for fattening purposes. A method was develope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf23e838fc43aea3051804a977b71a6c
https://pubmed.ncbi.nlm.nih.gov/28140792

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Selective androgen receptor modulators:in vitroandin vivometabolism and analysis

Autor: Saskia S. Sterk, Mario Thevis, Eva de Rijke, Leendert A. van Ginkel, Martien L. Essers, Toine F H Bovee, Jeroen C.W. Rijk

Publikováno v: Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 30(9), 1517-1526
Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment 30 (2013) 9

For future targeted screening in National Residue Control Programmes, the metabolism of seven SARMs, from the arylpropionamide and the quinolinone classes, was studied in vitro using S9 bovine liver enzymes. Metabolites were detected and identified w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1231437f9e51f5522d93188fc37934c
https://doi.org/10.1080/19440049.2013.810346

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Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry

Autor: Martien L. Essers, A.A.M. Stolker, Bjorn J.A. Berendsen, Robin S. Wegh, Stefan Weigel

Publikováno v: Analytical and Bioanalytical Chemistry, 402(4), 1611-1623
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry 402 (2012) 4

A liquid chromatography–tandem mass spectrometry method for the analysis of seven antiviral drugs, zanamivir, ribavirin, oseltamivir, oseltamivir carboxylate, amantadine, rimantadine and arbidol, in poultry muscle is reported. The antiviral drugs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21969559ad3d38e5d33ef7a8f258cf5
https://doi.org/10.1007/s00216-011-5581-3

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A generic method for the quantitative analysis of aminoglycosides (and spectinomycin) in animal tissue using methylated internal standards and liquid chromatography tandem mass spectrometry

Autor: Matthew Sharman, Frédérique L. van Holthoon, Marianne Caldow, Helen Ashwin, Patrick P.J. Mulder, Sara Stead, Martien L. Essers

Publikováno v: Analytica Chimica Acta 637 (2009) 1-2
Analytica Chimica Acta, 637(1-2), 135-143

Aminoglycosides (AGs) are a large and diverse group of antibiotics. Although AGs may cause side effects of nephrotoxicity and ototoxicity, they are still occasionally being used for the treatment of serious infections. In this study the development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe5de60b36523957437e0752e3ed97e
https://doi.org/10.1016/j.aca.2008.09.026

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Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine

Autor: Piet G. van Wikselaar, Ron L.A.P. Hoogenboom, A.S. Bulder, Ad M. van Vuuren, Jan C. H. van Eijkeren, T. Zuidema, Marcel Mengelers, Marco J. Zeilmaker, Martien L. Essers

Publikováno v: Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment 32 (2015) 8
Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 32(8), 1256-1264

Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under the so-called Cascade rules (off-label use), with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85407374ba023e5882e347210b37520d

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Peptide Fine Specificity of Anti-Glycoprotein 100 CTL Is Preserved Following Transfer of Engineered TCRαβ Genes Into Primary Human T Lymphocytes

Autor: Bram W. L. Essers, Gosse J. Adema, R. L. H. Bolhuis, Jolanda De Vries, Jan-Willem Gratama, Carl G. Figdor, Birgit Lankiewicz, Niels Schaft, Ralph A. Willemsen, Reno Debets

Publikováno v: Journal of Immunology, 170, 2186-2194. Amer assoc immunologists
Journal of Immunology, 170, 4, pp. 2186-94
Journal of Immunology, 170, 2186-94

Contains fulltext : 142336.pdf (Publisher’s version ) (Open Access) TCR with known antitumor reactivity can be genetically introduced into primary human T lymphocytes and provide promising tools for immunogene therapy of tumors. We molecularly char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685e0036ac4e7ef6f10530fe7ff92375
https://doi.org/10.4049/jimmunol.170.4.2186

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Bioactivity screening and mass spectrometric confirmation for the detection of PPAR-delta agonists that increase type 1 muscle fibres

Autor: Marco Blokland, Martien L. Essers, Astrid R. M. Hamers, Toine F.H. Bovee, Sander Kersten, Michel W. F. Nielen, H.H. Heskamp, Leendert A. van Ginkel

Publikováno v: Analytical and Bioanalytical Chemistry 406 (2014)
Analytical and Bioanalytical Chemistry, 406, 705-713

Sensitive and robust bioassays able to detect nuclear receptor activation are very useful for veterinary and doping control, pharmaceutical industry and environmental scientists. Here, we used bioassays based on human leukemic monocyte lymphoma U937

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f17b716531d37e76a6b237fdac64aa
https://research.wur.nl/en/publications/bioactivity-screening-and-mass-spectrometric-confirmation-for-the

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Quantitative trace analysis of eight chloramphenicol isomers in urine by chiral liquid chromatography coupled to tandem mass spectrometry

Autor: Linda Stolker, Martien L. Essers, Bjorn J.A. Berendsen, Michel W. F. Nielen

Publikováno v: Journal of Chromatography. A, Including electrophoresis and other separation methods, 1218(41), 7331-7340
Journal of Chromatography. A, Including electrophoresis and other separation methods 1218 (2011) 41

Chloramphenicol is a broad-spectrum antibiotic with, apart from its human medicinal use, veterinary abuse in all major food-producing animals. Chloramphenicol occurs in four stereoisomers (all para-nitro substituted) and furthermore four meta-nitro a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f267e8d5ee0d4c03257e1389b5d0391
https://pubmed.ncbi.nlm.nih.gov/21893319

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