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Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia

Autor: M K Eskandari, G Bolgos, C Miller, D T Nguyen, L E DeForge, D G Remick

Publikováno v: The Journal of Immunology. 148:2724-2730

Cytokines have been studied intensively to delineate their role in the altered pathophysiology observed in septic shock. We studied the role of TNF in the lethality of two well characterized models of septic shock by inhibiting TNF's activity with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9986fc825c7017940abf73fe8a220a48
https://doi.org/10.4049/jimmunol.148.9.2724

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Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood. Separation of LPS- and cytokine-stimulated components using anti-tumor necrosis factor and anti-IL-1 antibodies

Autor: L E DeForge, J S Kenney, M L Jones, J S Warren, D G Remick

Publikováno v: The Journal of Immunology. 148:2133-2141

TNF, IL-1, and IL-6 are integral components of the cytokine cascade released in the response to inflammatory stimuli such as LPS. IL-8 is produced both in response to LPS as well as TNF and IL-1. The early, local production of TNF and IL-1 may theref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88543959ced832b54d129d09b6248c66
https://doi.org/10.4049/jimmunol.148.7.2133

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Cyclosporin a modulation of tumor necrosis factor gene expression and effects in vitro and in vivo

Autor: D T Nguyen, M K Eskandai, L E DeForge, C L Raiford, R M Strieter, S L Kunkel, D G Remick

Publikováno v: The Journal of Immunology. 144:3822-3828

We investigated, in vitro and in vivo, the cyclosporin A (CsA) regulation of LPS-induced TNF gene expression and subsequent pathophysiologic changes. In vitro dose-response kinetics data showed that CsA inhibited TNF bioactivity in the supernatant wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::368c86608cd4922c0544767ab0f83194
https://doi.org/10.4049/jimmunol.144.10.3822

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Rheumatoid arthritis and other inflammatory joint diseases (animal models) (WS-037)

Publikováno v: International Immunology. 22:ii104-ii105

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fd9e83dd66f2d26263ee761147a535e
https://doi.org/10.1093/intimm/dxq300

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Effect of IFN-gamma on the killing of S. aureus in human whole blood. Assessment of bacterial viability by CFU determination and by a new method using alamarBlue

Autor: L E, DeForge, K L, Billeci, S M, Kramer

Publikováno v: Journal of immunological methods. 245(1-2)

Given the increasing incidence of methicillin resistant Staphylococcus aureus (MRSA) and the recent emergence of MRSA with a reduced susceptibility to vancomycin, alternative approaches to the treatment of infection are of increasing relevance. The p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc888f17accece3b6682a0cf5e8f86d9
https://pubmed.ncbi.nlm.nih.gov/11042285

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IL-8 single-chain homodimers and heterodimers: interactions with chemokine receptors CXCR1, CXCR2, and DARC

Autor: S R, Leong, H B, Lowman, J, Liu, S, Shire, L E, Deforge, B L, Gillece-Castro, R, McDowell, C A, Hébert

Publikováno v: Protein science : a publication of the Protein Society. 6(3)

Covalent single-chain dimers of the chemokine interleukin-8 (IL-8) have been designed to mimic the dimeric form of IL-8 in solution and facilitate the production of heterodimer variants of IL-8. Physical studies indicated that use of a simple peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76e99dd3a46e6690607467031fb0c363
https://pubmed.ncbi.nlm.nih.gov/9070443

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Regulation of interleukin 8 gene expression by oxidant stress

Autor: L E, DeForge, A M, Preston, E, Takeuchi, J, Kenney, L A, Boxer, D G, Remick

Publikováno v: The Journal of biological chemistry. 268(34)

Interleukin 8 (IL-8) is a recently described cytokine that functions as a potent neutrophil chemoattractant and activator. We sought to examine the link between the generation of reactive oxygen intermediates (ROI) and the regulation of IL-8 gene exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a8b191fe6d51463a06cd2cf3d1f99a6a
https://pubmed.ncbi.nlm.nih.gov/8244994

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Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia

Autor: M K, Eskandari, G, Bolgos, C, Miller, D T, Nguyen, L E, DeForge, D G, Remick

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 148(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88143c0e062b64953e26bbec311779eb
https://pubmed.ncbi.nlm.nih.gov/1315357

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IL-8 in septic shock, endotoxemia, and after IL-1 administration

Autor: K J, Van Zee, L E, DeForge, E, Fischer, M A, Marano, J S, Kenney, D G, Remick, S F, Lowry, L L, Moldawer

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 146(10)

Much effort has been directed toward elucidating the host response to sepsis and inflammation, resulting in the definition of a cascade of endogenous mediators that direct metabolic and immunological responses. Here we report that IL-8, a novel cytok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f8fa2b4ccbd9acc42bacd53907c0f11
https://pubmed.ncbi.nlm.nih.gov/2026876

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