Výsledky vyhledávání - "L E, Schnipper"

DNA topoisomerase II alpha expression is associated with alkylating agent resistance

Autor: J P, Eder, V T, Chan, S W, Ng, N A, Rizvi, S, Zacharoulis, B A, Teicher, L E, Schnipper

Publikováno v: Cancer research. 55(24)

Increased expression of DNA topoisomerase II alpha has been associated with resistance to certain DNA-damaging alkylating agents, but no causal relationship or mechanism has been established. To investigate this observation, we developed a model of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e123e88d8066f1404b08ad8041fc5939
https://pubmed.ncbi.nlm.nih.gov/8521401

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Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: complete response in a patient with Hodgkin's disease refractory to chemotherapy

Autor: I, Tepler, G, Schwartz, K, Parker, J, Charette, M E, Kadin, T G, Woodworth, L E, Schnipper

Publikováno v: Cancer. 73(4)

DAB486IL-2 is a recombinant fusion toxin in which the native diphtheria toxin-receptor binding-domain has been replaced with human interleukin-2 (IL-2). This molecule is specifically cytotoxic in vitro within 30 minutes for cells that express the hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4959c7d94bd70a16ea9bb341aeb853a
https://pubmed.ncbi.nlm.nih.gov/8313331

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High-dose cyclophosphamide, thiotepa, and carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy: analysis by age

Autor: K, Antman, L, Ayash, A, Elias, C, Wheeler, G, Schwartz, R, Mazanet, I, Tepler, L E, Schnipper, E, Frei

Publikováno v: Journal of the National Cancer Institute. Monographs. (16)

The analysis was undertaken to determine if the time to progression and survival for women with breast cancer treated with high-dose chemotherapy after a conventional-dose induction therapy differs significantly for women younger and older than 40 ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb0f538ec072908b167a7d59dadf4a9c
https://pubmed.ncbi.nlm.nih.gov/7528031

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Conditional expression of wild-type topoisomerase II complements a mutant enzyme in mammalian cells

Autor: J P, Eder, V T, Chan, E, Niemierko, B A, Teicher, L E, Schnipper

Publikováno v: The Journal of biological chemistry. 268(19)

Alterations in the amino acid composition, phosphorylation pattern, or intracellular levels of topoisomerase II have been associated with resistance to antineoplastic agents whose effects are mediated through interactions with this enzyme. To develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b3829f793ce6d727d8c12010ffaf3e9
https://pubmed.ncbi.nlm.nih.gov/8390979

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Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line

Autor: V T, Chan, S W, Ng, J P, Eder, L E, Schnipper

Publikováno v: The Journal of biological chemistry. 268(3)

Topoisomerase II (Top II) is the target enzyme for many antineoplastic drugs such as epipodophyllotoxins, anthracyclines, and acridines. Cell lines with alterations in Top II are resistant to drugs that interact with the enzyme. Studies of the Top II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb09006a95944f3a8aec376ed6eeb2e7
https://pubmed.ncbi.nlm.nih.gov/8380592

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Pulmonary toxicity associated with high dose chemotherapy in the treatment of solid tumors with autologous marrow transplant: an analysis of four chemotherapy regimens

Autor: M V, Seiden, A, Elias, L, Ayash, M, Hunt, J P, Eder, L E, Schnipper, E, Frei, K H, Antman

Publikováno v: Bone marrow transplantation. 10(1)

We retrospectively reviewed the pulmonary toxicity of six high dose chemotherapy protocols using four chemotherapy regimens in the treatment of solid tumors. All protocols used either high dose cyclophosphamide or ifosfamide in combination with one t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bf2c97e91139bd30e426860d61b753d
https://pubmed.ncbi.nlm.nih.gov/1515880

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Cisplatin, continuous-infusion 5-fluorouracil, and intermediate-dose methotrexate in the treatment of unresectable non-small cell carcinoma of the lung

Autor: C A, Wheeler, L N, Shulman, T, Ervin, S E, Come, L E, Schnipper

Publikováno v: Cancer. 67(4)

Forty-one patients with unresectable non-small cell carcinoma of the lung (NSCCL) were treated with cisplatin 20 mg/m2/d for 5 days as a daily bolus injection, 5-fluorouracil 800 mg/m2/d by continuous infusion for 5 days, and intermediate-dose methot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3524758d12e073c0f558851ead2a0506
https://pubmed.ncbi.nlm.nih.gov/1846768

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Malignant melanoma. Treatment with high-dose combination alkylating agent chemotherapy and autologous bone marrow support

Autor: T C, Shea, K H, Antman, J P, Eder, A, Elias, W P, Peters, S, Schryber, W D, Henner, D A, Schoenfeld, L E, Schnipper, E, Frei

Publikováno v: Archives of Dermatology. 124:878-884

Nineteen patients with metastatic malignant melanoma were treated with 20 courses of high-dose combination alkylating agent chemotherapy and autologous bone marrow support. All 20 treatment courses were evaluable for toxic reactions and 17 of 20 cour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a771af4eb223795f3e5e353d503aef
https://doi.org/10.1001/archderm.124.6.878

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