Zobrazeno 1 - 6
of 6
pro vyhledávání: '"L E, Los"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(1)
Diltiazem (DTZ), a calcium channel blocker, and enalapril (EN), an angiotensin-converting enzyme inhibitor, are being developed as combination therapy for cardiovascular disease. A toxicokinetic evaluation of EN and DTZ drug levels during a 27-week t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1528837cbcbbda6ad70d5f9c4c5874ab
https://pubmed.ncbi.nlm.nih.gov/8825187
https://pubmed.ncbi.nlm.nih.gov/8825187
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(6)
Spironolactone (SP) is used clinically as a renal aldosterone antagonist and as an antiandrogen. It is known that the drug is extensively metabolized and that metabolites mediate its therapeutic actions, but hepatic metabolism of SP has not been comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5d5d7d0a0588609137377eaefe12727
https://pubmed.ncbi.nlm.nih.gov/7895608
https://pubmed.ncbi.nlm.nih.gov/7895608
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(6)
Spironolactone (SL) is a renal aldosterone antagonist that is used clinically in the treatment of hypertension and congestive heart failure. Among the side effects of the drug are degradation of cytochrome P-450 and inhibition of steroidogenesis in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ae2e6ef2ddf71200c64cab0a955c3fc
https://pubmed.ncbi.nlm.nih.gov/7905388
https://pubmed.ncbi.nlm.nih.gov/7905388
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(1)
[5,6-dihydro-4H-4(isobutylamino)thieno(2,3-B)thiopyran-2-sul fonamide-7,7- dioxide] (MK-927), a potent carbonic anhydrase inhibitor capable of reducing intraocular pressure after topical application, is currently under investigation for the treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d30370782023fa6f9e32164ef14dc5ca
https://pubmed.ncbi.nlm.nih.gov/1673405
https://pubmed.ncbi.nlm.nih.gov/1673405
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 16(1)
The H2-receptor antagonists famotidine and cimetidine are both basic drugs that are predominantly eliminated by the kidneys. Cimetidine has been shown to inhibit the renal secretion of tetraethyl-ammonium bromide (TEAB) but not p-aminohippuric acid (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bc516a760f8d8e618bb71bf2b37fb2d
https://pubmed.ncbi.nlm.nih.gov/2894955
https://pubmed.ncbi.nlm.nih.gov/2894955
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(2)
Famotidine is a new histamine H2-receptor antagonist which has been demonstrated to be more potent than cimetidine and ranitidine in inhibiting gastric acid secretion. Nine groups of adult male Sprague-Dawley rats received an ia injection of various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fe2ab2d246157671dcdd2baaf14b6f8
https://pubmed.ncbi.nlm.nih.gov/2882981
https://pubmed.ncbi.nlm.nih.gov/2882981