Zobrazeno 1 - 10
of 15
pro vyhledávání: '"L E, Dillehay"'
Autor:
E, Weber, R K, Ravi, E S, Knudsen, J R, Williams, L E, Dillehay, B D, Nelkin, G P, Kalemkerian, J R, Feramisco, M, Mabry
Publikováno v:
International journal of cancer. 80(6)
Human lung cancer cells, including small cell lung carcinoma (SCLC), frequently lose expression of retinoic acid receptor beta (RAR-beta) and are resistant to the growth inhibitory activity of all-trans retinoic acid (RA). To elucidate the role of RA
Publikováno v:
Journal of cellular biochemistry. 72(4)
Prostate cancer is the most commonly diagnosed neoplasm in men. LNCaP cells continue to possess many of the molecular characteristics of in situ prostate cancer. These cells lack ras mutations, and mitogen-activated protein kinase (MAPK) is not exten
Publikováno v:
Radiation oncology investigations. 6(6)
Clinical modulation of radiosensitivity via combined fractionated high dose rate and continuous ultra-low dose rate irradiation (ULDR) holds promise for the radiosensitization of human malignant gliomas. We measured both the in vitro and in vivo resp
Publikováno v:
Radiation oncology investigations. 6(2)
The purpose of this study was to investigate the feasibility and the efficacy of administering tirapazamine by a slow-releasing polymer disc that was implanted interstitially into a U251 (human glioblastoma multiforme) tumor grown in nude mice. Tumor
Publikováno v:
Journal of neuro-oncology. 32(3)
The potential of halogenated pyrimidines for the radiosensitization of human malignant gliomas remains unrealized. To assess the role of local delivery for radiosensitization, we tested a synthetic, implantable biodegradable polymer for the controlle
Autor:
L E, Dillehay
Publikováno v:
Anticancer research. 17(1A)
High interstitial pressure limits the uptake of systemically-administered macromolecular agents. Fast infusion, which has been found to spread by convection macromolecules in the brain, was examined in a xenograft tumor system. Subcutaneous human U25
Publikováno v:
Cancer. 73
Large differences in uptake between tumors, even for the same size, frequently observed in clinical and experimental radioimmunotherapy (RAIT), make monitoring of uptake in individual tumors imperative in comparing protocols. 90Y, widely-used for RAI
Autor:
L E, Dillehay
Publikováno v:
Radiation research. 124(2)
A computer model that simulates the killing of exponentially growing cells by low-dose-rate radiation is described. The model incorporates cell killing by single-hit damage and double-hit (sublethal) damage, as well as repair of sublethal damage, del
Autor:
L E, Dillehay, J R, Williams
Publikováno v:
Frontiers of radiation therapy and oncology. 24
Publikováno v:
Radiation research. 117(1)
The ability of mutagens to transform benign papillomas to malignancy in the mouse skin model of multistage carcinogenesis [Hennings et al. Nature 303, 67-68 (1983)] suggests that multiple events may underlie carcinogenic progression, and that mutagen