Zobrazeno 1 - 10
of 78
pro vyhledávání: '"L Dragone"'
Autor:
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces
Externí odkaz:
https://doaj.org/article/9d629b4edd534fecb283ec7b354fbbc7
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 31, Iss 2, Pp 492-497 (2017)
Background Spinal walking (SW) is described as the acquisition of an involuntary motor function in paraplegic dogs and cats without pain perception affected by a thoracolumbar lesion. Whereas spinal locomotion is well described in cats that underwent
Externí odkaz:
https://doaj.org/article/5e9c246230ae4c41a57e4922224528aa
Autor:
Adrianne L Stefanski, Nadine Martinez, Lisa K Peterson, Tiffany J Callahan, Eric Treacy, Marisa Luck, Samantha F Friend, Amy Hermesch, Emin Maltepe, Tzu Phang, Leonard L Dragone, Virginia D Winn
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0210675 (2019)
The role of extracellular vesicles (EVs), specifically exosomes, in intercellular communication likely plays a key role in placental orchestration of pregnancy and maternal immune sensing of the fetus. While murine models are powerful tools to study
Externí odkaz:
https://doaj.org/article/bf5c81930da2441986c3852e3afc3a04
Akademický článek
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The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation.
Autor:
Samantha F Friend, Lisa K Peterson, Eric Treacy, Adrianne L Stefanski, Tomasz Sosinowski, Nathan D Pennock, Allison J Berger, Virginia D Winn, Leonard L Dragone
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75200 (2013)
While neddylation is known to activate cullin (CUL)-RING ubiquitin ligases (CRLs), its role in regulating T cell signaling is poorly understood. Using the investigational NEDD8 activating enzyme (NAE) inhibitor, MLN4924, we found that neddylation neg
Externí odkaz:
https://doaj.org/article/a9831c2e8e4c40d781ac6f9850536470
Autor:
Jian Dai, Margaret Vesselits, Michael K. Okoreeh, Nirit Mor Vaknin, Leonard L Dragone, Kichul Ko, Andrew J Kinloch, Maureen Legendre, Michael J. Townsend, David M. Markovitz, Matthew D Cascino, Marcus R. Clark, Rene S. Bermea
Publikováno v:
Lupus
BackgroundTubulointerstitial inflammation (TII) in lupus nephritis is associated with a worse prognosis. Vimentin, a filamental antigen, is commonly targeted by in situ activated B-cells in TII. The prognostic importance of high serum anti-vimentin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ebe7d221fbf680686b64614fedc8e3
https://europepmc.org/articles/PMC7278023/
https://europepmc.org/articles/PMC7278023/
Autor:
Kent Riemondy, Anjana Rao, Brian P. O'Connor, S. Harsha Krovi, Laurent Gapin, Adam R. Lefferts, Jay R. Hesselberth, Leonard L. Dragone, Catherine Halluszczak, Philippa Marrack, Jingjing Zhang, Lisa K. Peterson, Kathryn D. Tuttle, Laura Harmacek, James P. Scott-Browne, Romain Bedel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e4c35d3becfa75c6b45c62a82a633
http://link.springer.com/article/10.1038/s41467-018-05026-6
http://link.springer.com/article/10.1038/s41467-018-05026-6
Publikováno v:
Poster Presentations.
Background LUNAR, a randomized controlled trial, investigated the addition of rituximab (RTX) to standard of care for the treatment of lupus nephritis (LN). While this study did not meet its primary endpoint, there was an increase in partial renal re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9aeda3400553b883ad788a8c00882c
https://doi.org/10.1136/annrheumdis-2017-eular.5412
https://doi.org/10.1136/annrheumdis-2017-eular.5412
Publikováno v:
Poster Presentations.
Background Systemic lupus erythematosus (SLE) is heterogeneous in its clinical presentation, course, and prognosis and lupus nephritis (LN) continues to be a major cause of morbidity and mortality among children and adults with SLE. Up to 60% of adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ade180df31dd40545dd55ff92391049
https://doi.org/10.1136/annrheumdis-2017-eular.5526
https://doi.org/10.1136/annrheumdis-2017-eular.5526
Publikováno v:
Poster Presentations.
Background Early identification of patients with lupus nephritis (LN) likely to achieve complete renal response (CRR) may expedite the evaluation of new therapies and guide clinical care. Prior analyses have shown that early improvement in proteinuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5d40a52915a50cb00aa058bfb862f0
https://doi.org/10.1136/annrheumdis-2017-eular.5414
https://doi.org/10.1136/annrheumdis-2017-eular.5414