Zobrazeno 1 - 10 of 106 pro vyhledávání: '"L D Shultz"'
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Preservation of Functioning Human Thyroid 'Organoids' in the scid Mouse. IV. In Vivo Selection of an Intrathyroidal T Cell Receptor Repertoire*
Autor: E. W. Friedman, A. Martin, Pamela D. Unger, J. Zhang, A. Zhou, Arthur E. Schwartz, M. Nakashima, N Matsuoka, Terry F. Davies, L D Shultz
Publikováno v: Endocrinology. 138:4868-4875
To study the in vivo influence of thyroid cells on the T cell receptor repertoire in human autoimmune thyroid disease, we mixed lymphocyte-free thyrocytes (approximately 1.2 x 10[6]) from patients with Graves' disease with autologous peripheral blood
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0dca94dde9efc53377d85bffc7ac76
https://doi.org/10.1210/endo.138.11.5537
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3
DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance
Autor: C M Westhoff, A Whittier, S Kathol, J McHugh, C Zajicek, L D Shultz, D E Wylie
Publikováno v: The Journal of Immunology. 159:3024-3033
C57BL/6 me(v)/me(v) (viable motheaten) mice have defective hemopoietic cell protein-tyrosine phosphatase (HCP, SHP-1) and are a model in which to study the role of this phosphatase in immune regulation and hemopoietic development. Immune defects in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1154fd0ed3dc164882dfd547ec64ded1
https://doi.org/10.4049/jimmunol.159.6.3024
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4
Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent
Autor: D V Serreze, H D Chapman, D S Varnum, I Gerling, E H Leiter, L D Shultz
Publikováno v: The Journal of Immunology. 158:3978-3986
MHC class II alleles clearly contribute a primary genetic component of susceptibility to autoimmune insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. However, IDDM does not occur in NOD mice made MHC class I-deficient by a f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::288ddd57cf95152a1cd54929bd6e5c0a
https://doi.org/10.4049/jimmunol.158.8.3978
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6
Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice
Autor: D T Kim, Cariel Taylor Edwards, C G Fathman, L D Shultz, Brett Charlton, P W Rohane, A. Shimada
Publikováno v: Diabetes. 44:550-554
In an effort to study the development of diabetes in NOD mice, our laboratory developed a novel adoptive transfer model using NOD-scid/scid (NOD-scid) mice as recipients of islet-infiltrating lymphocytes from donor prediabetic female NOD mice. We fir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14879e3de651170dd318e39bf07c6c08
https://doi.org/10.2337/diabetes.44.5.550
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7
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
Autor: L D Shultz, P A Schweitzer, S W Christianson, B Gott, I B Schweitzer, B Tennent, S McKenna, L Mobraaten, T V Rajan, D L Greiner
Publikováno v: The Journal of Immunology. 154:180-191
The scid mutation was backcrossed ten generations onto the NOD/Lt strain background, resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive as well as nonadaptive immunologic function. NOD/LtSz-scid/scid mice lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cda21d0949980f74efcaf8a158ac633a
https://doi.org/10.4049/jimmunol.154.1.180
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8
Engraftment of human lymphocytes and thyroid tissue into scid and rag2-deficient mice: absent progression of lymphocytic infiltration
Autor: Terry F. Davies, A. Martin, M Valentine, Pamela D. Unger, S W Yeung, L D Shultz
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 79:716-723
To study human autoimmune thyroid disease in an animal model we have investigated the in vivo survival of human thyroid tissues and functionality of human lymphocytes in severe combined immunodeficient (scid) mice and recombination-activating gene (r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1978c51f46aa7f237e2010112e0af487
https://doi.org/10.1210/jcem.79.3.8077352
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9
Preservation of functioning human thyroid 'organoids' in the severe combined immunodeficient mouse. III. Thyrotropin independence of thyroid follicle formation
Autor: Terry F. Davies, N Katz, L D Shultz, A. Martin, M Valentine, Pamela D. Unger
Publikováno v: Endocrinology. 134:1225-1230
The severe combined immunodeficient (scid) mouse allows the in vivo reconstitution of thyroid follicles from thyroid monolayer cells when transplanted sc within an extracellular basement membrane matrix. After 2-3 weeks, these human thyroid organoids
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a00debfff56e57a9ee981b0d477fef1
https://doi.org/10.1210/endo.134.3.8119163
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