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Evidence that the inhibition of cartilage proteoglycan breakdown by mannosamine is not mediated via inhibition of glycosylphosphatidylinositol anchor formation

Autor: R N Johnatty, R.A.D. Bunning, H. Bryson, David J. Buttle, L D Kozaci

Publikováno v: Biochemical Journal. 345:495-501

The effect of mannosamine, an inhibitor of glycosylphosphatidylinositol (GPI) anchor formation, on chondrocyte-mediated cartilage proteoglycan breakdown was investigated using cartilage explant cultures. Mannosamine inhibited interleukin 1α-, tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ac295083c9524e40ed370e721cf4c5c
https://doi.org/10.1042/bj3450495

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Effects of growth factors and interleukin-1 alpha on proteoglycan and type II collagen turnover in bovine nasal and articular chondrocyte pellet cultures

Autor: L. D. Kozaci, Anthony P. Hollander, Roslin Russell, Astrid Frazer, Babatunde O. Oyajobi, C. Xu

Publikováno v: Endocrinology. 137:3557-3565

The aim of this study was to investigate the effects of insulin-like growth factor-I, transforming growth factor-beta (TGF-beta), and interluekin-1 alpha (IL-1 alpha) on the deposition and degradation of a cartilage-like matrix in high-density pellet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3312f637ba026e1e9899e1ccc729806
https://doi.org/10.1210/endo.137.8.8754787

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Evidence that the inhibition of cartilage proteoglycan breakdown by mannosamine is not mediated via inhibition of glycosylphosphatidylinositol anchor formation

Autor: H, Bryson, D J, Buttle, L D, Kozaci, R N, Johnatty, R A, Bunning

Publikováno v: The Biochemical journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77cf6b2540782d0a00060889fb6ff7dc
https://pubmed.ncbi.nlm.nih.gov/10642507

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Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown

Autor: C Adcocks, D J Buttle, L D Kozaci, A P Hollander, C J Brown, Andy Galloway

Publikováno v: Molecular pathology : MP. 51(5)

AIMS: To determine the collective roles of stromelysin 1, neutrophil collagenase, and collagenase 3 in chondrocyte mediated cartilage proteoglycan and type II collagen degradation in tissue culture model systems. METHODS: Bovine nasal cartilage expla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c770f48012b71e41dc2599c84b2e2b2f
https://pubmed.ncbi.nlm.nih.gov/10193524

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Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures

Autor: J S, Price, S, Wang-Weigand, R, Bohne, L D, Kozaci, A P, Hollander

Publikováno v: Arthritis and rheumatism. 42(1)

To determine the role of matrix metalloproteinases (MMPs) in retinoic acid (RetA)-induced degradation of type II collagen in cartilage.Bovine nasal cartilage explants were cultured with 1 microM RetA or in 3 nM interleukin-1alpha (IL-1alpha). Release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea228f1dacdca82260214af0a615cddf
https://pubmed.ncbi.nlm.nih.gov/9920024

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