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Akademický článek

Loss of ZNF148 enhances insulin secretion in human pancreatic β cells

Autor: Eleonora de Klerk, Yini Xiao, Christopher H. Emfinger, Mark P. Keller, David I. Berrios, Valentina Loconte, Axel A. Ekman, Kate L. White, Rebecca L. Cardone, Richard G. Kibbey, Alan D. Attie, Matthias Hebrok

Publikováno v: JCI Insight, Vol 8, Iss 11 (2023)

Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. Defects in this process result in diabetes. Identifying genetic regulators that impair insulin secretion is crucial for the identification of novel the

Externí odkaz: https://doaj.org/article/b4b5dbeb38934b90baccd9d13f8ca114

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Akademický článek

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

Autor: Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins

Publikováno v: eLife, Vol 11 (2022)

Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP c

Externí odkaz: https://doaj.org/article/fa152f2fa3f04b6c9965e3c25ec9218f

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Akademický článek

β Cell–specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses

Publikováno v: JCI Insight, Vol 7, Iss 10 (2022)

Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell–specific deletion of Zfp148 (β-Zfp148KO) improves glucose to

Externí odkaz: https://doaj.org/article/89940b8a0be241239ae78674f9a31df7

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Akademický článek

Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

Autor: Neha Bhat, Anand Narayanan, Mohsen Fathzadeh, Mario Kahn, Dongyan Zhang, Leigh Goedeke, Arpita Neogi, Rebecca L. Cardone, Richard G. Kibbey, Carlos Fernandez-Hernando, Henry N. Ginsberg, Dhanpat Jain, Gerald I. Shulman, Arya Mani

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)

Mutations in Dyrk1b are associated with metabolic syndrome and nonalcoholic fatty liver disease in humans. Our investigations showed that DYRK1B levels are increased in the liver of patients with nonalcoholic steatohepatitis (NASH) and in mice fed wi

Externí odkaz: https://doaj.org/article/081ebed6b4d0408c85b832ff0ab525fb

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Akademický článek

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

Autor: Rachel J. Perry, Aviva Rabin-Court, Joongyu D. Song, Rebecca L. Cardone, Yongliang Wang, Richard G. Kibbey, Gerald I. Shulman

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

The use of sodium-glucose transport protein 2 (SGLT2) inhibitors for the treatment of diabetes has been associated with euglycemic ketoacidosis and increased glucose production and glucagon secretion. Here Perry et al. show that these effects rely on

Externí odkaz: https://doaj.org/article/1491a567866a435e9938ca80389140c5

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Akademický článek

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

Autor: Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart

Publikováno v: Cell Reports, Vol 29, Iss 11, Pp 3394-3404.e9 (2019)

Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-f

Externí odkaz: https://doaj.org/article/843a5a89bddc469f9d601bd5b6452f15

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Akademický článek

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Autor: Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, William M. Philbrick, Ian R. Sweet, Orian H. Shirihai, Richard G. Kibbey

Publikováno v: Cell Reports, Vol 28, Iss 3, Pp 759-772.e10 (2019)

Summary: Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the mitochondrial GTP (mtGTP) cycle. In this cycle, mtGTP synthesized by s

Externí odkaz: https://doaj.org/article/be7e1143ef2a432fb03f9abb2af5253d

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Akademický článek

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