Deep-Sea Sponges and Corals off the Western Coast of Florida—Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances Supporting the Drug Discovery Pipeline

Autor: Mina Iskandar, Kira M. Ruiz-Houston, Steven D. Bracco, Sami R. Sharkasi, Cecilia L. Calabi Villarroel, Meghna N. Desai, Alexandra G. Gerges, Natalia A. Ortiz Lopez, Miguel Xiao Barbero, Amelia A. German, Vinoothna S. Moluguri, Selina M. Walker, Juliana Silva Higashi, Justin M. Palma, Daena Z. Medina, Miit Patel, Prachi Patel, Michaela Valentin, Angelica C. Diaz, Jonathan P. Karthaka, Atzin D. Santiago, Riley B. Skiles, Luis A. Romero Umana, Maxwell D. Ungrey, Anya Wojtkowiak, Domenica V. Howard, Remy Nurge, Katharine G. Woods, Meera Nanjundan

Publikováno v: Marine Drugs, Vol 21, Iss 12, p 615 (2023)

The majority of natural products utilized to treat a diverse array of human conditions and diseases are derived from terrestrial sources. In recent years, marine ecosystems have proven to be a valuable resource of diverse natural products that are ge

Externí odkaz: https://doaj.org/article/53d4c3203f9148e6a94a706813d12a0e

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On Darwin's 'metaphysical notebooks'. II: 'Metaphysics' and final cause

Autor: L, Calabi

Publikováno v: Rivista di biologia. 94(2)

The first part of this paper was published in Rivista di Biologia/Biology Forum 94 (2001). In the second part below an examination is made of the meaning of the term Metaphysics in some passages of the Darwinian Notebooks for the years 1836-1844. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0601e65bfdc960fe3ed85c51360cff0d
https://pubmed.ncbi.nlm.nih.gov/11702652

Gadobenate dimeglumine 0.5 M solution for injection (MultiHance) pharmaceutical formulation and physicochemical properties of a new magnetic resonance imaging contrast medium

Autor: L Calabi, M Cabrini, L Akhnana, C. De Haën, D Ratti, Luigia Gozzini

Publikováno v: Journal of computer assisted tomography. 23

Objective: To characterize the proton-magnetic relaxation properties and complexation equilibria of gadobenate dimeglumine and to develop a pharmaceutical formulation for injection. Methods: Proton-magnetic relaxivities were determined at 20 MHz and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d0d1a4908ceaeb743019f19d92f02b
https://pubmed.ncbi.nlm.nih.gov/10608412

[Gd(HB-DO3A)]: Equilibrium, Dissociation Kinetic and Structural Differences in a Simple Homolog of [Gd(HP-DO3A)] (Prohance ^® ).

Autor: Versolatto S; Dipartimento di Scienze Chimiche e Farmaceutiche Università di Trieste, Piazzale Europa 1, 34127, Trieste, TS, Italy., Boccalon M; Bracco Imaging Spa, CRB Trieste, AREA Science Park, 34149, Basovizza, TS, Italy., Guidolin N; Bracco Imaging Spa, CRB Trieste, AREA Science Park, 34149, Basovizza, TS, Italy., Travagin F; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, Novara, NO, 28100, Italy., Alessio E; Dipartimento di Scienze Chimiche e Farmaceutiche Università di Trieste, Piazzale Europa 1, 34127, Trieste, TS, Italy., Aime S; IRCCS SDN Research Institute Diagnostics and Nuclear SynLab, Via Emanuele Gianturco, 113, 80143, Napoli, NA, Italy., Balducci G; Dipartimento di Scienze Chimiche e Farmaceutiche Università di Trieste, Piazzale Europa 1, 34127, Trieste, TS, Italy., Giovenzana GB; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, Novara, NO, 28100, Italy., Baranyai Z; Bracco Imaging Spa, CRB Trieste, AREA Science Park, 34149, Basovizza, TS, Italy.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 May 17; Vol. 30 (28), pp. e202400344. Date of Electronic Publication: 2024 Apr 04.