Zobrazeno 1 - 10
of 33
pro vyhledávání: '"L C McPhail"'
Autor:
S Sergeant, L C McPhail
Publikováno v:
The Journal of Immunology. 159:2877-2885
We examined the ability of opsonized zymosan (OPZ) to stimulate translocation of protein kinase C (PKC) isoforms in human neutrophils. Neutrophils express five PKC isoforms (alpha, betaI, betaII, delta, and zeta), but little is known of their individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e8ca7304735520c4dc5157fb246a42
https://doi.org/10.4049/jimmunol.159.6.2877
https://doi.org/10.4049/jimmunol.159.6.2877
Publikováno v:
The Journal of Immunology. 157:4641-4647
The intracellular mechanisms that regulate the function of human neutrophils are not well understood. Receptor-initiated signaling events result in the production of several second messengers (e.g., Ca2+, diacylglycerol, phosphatidic acid, and arachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3bd6577f8a2444807b84321a4966110
https://doi.org/10.4049/jimmunol.157.10.4641
https://doi.org/10.4049/jimmunol.157.10.4641
Publikováno v:
The Journal of Immunology. 146:3895-3903
In human neutrophils, the chemotactic tripeptide FMLP and the protein kinase C activator PMA stimulate the breakdown of 1-O-[3H]alkyl-2-acyl-sn-glycero-3-phosphocholine ([3H]EAPC) and the formation of 1-O-[3H]alkyl-2-acyl-phosphatidic acid ([3H]-EAPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a802a467db7b1ded5a25ef233bc49b2
https://doi.org/10.4049/jimmunol.146.11.3895
https://doi.org/10.4049/jimmunol.146.11.3895
Publikováno v:
The Journal of biological chemistry. 276(7)
In human neutrophils, the activation of phospholipase D and the Tyr phosphorylation of proteins are early signaling events upon cell stimulation. We found that the pretreatment of neutrophils with ethanol (0.8%) or 1-butanol (0.3%), which results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eec337b9fc936402ff726e049c1c494d
https://pubmed.ncbi.nlm.nih.gov/11078731
https://pubmed.ncbi.nlm.nih.gov/11078731
Publikováno v:
The Journal of biological chemistry. 275(37)
Human neutrophils participate in the host innate immune response, partly mediated by the multicomponent superoxide-generating enzyme NADPH oxidase. A correlation between phosphorylation of cytosolic NADPH oxidase components and enzyme activation has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85ea804bcc659fbbac14915c44479171
https://pubmed.ncbi.nlm.nih.gov/10893420
https://pubmed.ncbi.nlm.nih.gov/10893420
Autor:
J B, Nixon, L C, McPhail
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(8)
The responses of human neutrophils (PMN) involve reorganization and phosphorylation of cytoskeletal components. We investigated the translocation of protein kinase C (PKC) isoforms to PMN cytoskeletal (Triton-insoluble) fractions, in conjunction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df7816592ebf12c9cc4ebb827b0774d8
https://pubmed.ncbi.nlm.nih.gov/10510401
https://pubmed.ncbi.nlm.nih.gov/10510401
Autor:
S, Sergeant, L C, McPhail
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(6)
We examined the ability of opsonized zymosan (OPZ) to stimulate translocation of protein kinase C (PKC) isoforms in human neutrophils. Neutrophils express five PKC isoforms (alpha, betaI, betaII, delta, and zeta), but little is known of their individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22d326ca4af974c6698af24e9500e94f
https://pubmed.ncbi.nlm.nih.gov/9300711
https://pubmed.ncbi.nlm.nih.gov/9300711
Publikováno v:
The Journal of biological chemistry. 272(24)
Phosphatidic acid (PA), generated by phospholipase D activation, has been linked to the activation of the neutrophil respiratory burst enzyme, NADPH oxidase; however, the intracellular enzyme targets for PA remain unclear. We have recently shown (McP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a735ad4c064e748073e4b518b6024865
https://pubmed.ncbi.nlm.nih.gov/9182594
https://pubmed.ncbi.nlm.nih.gov/9182594
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(10)
The intracellular mechanisms that regulate the function of human neutrophils are not well understood. Receptor-initiated signaling events result in the production of several second messengers (e.g., Ca2+, diacylglycerol, phosphatidic acid, and arachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cc08f01b293caa3c4a0f3095e8be56a
https://pubmed.ncbi.nlm.nih.gov/8906844
https://pubmed.ncbi.nlm.nih.gov/8906844
Publikováno v:
The Journal of biological chemistry. 268(32)
NADPH oxidase, the respiratory burst enzyme of human neutrophils, is a multi-component complex that is assembled and activated during stimulation of the cells by inflammatory or phagocytic stimuli. The signal mechanisms leading to activation of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a9f309875ae96f5f08b7a67a33c05a1
https://pubmed.ncbi.nlm.nih.gov/8226922
https://pubmed.ncbi.nlm.nih.gov/8226922