Zobrazeno 1 - 6 of 6 pro vyhledávání: '"L C Hsi"'
1
Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice
Autor: J D Roberts, L C Hsi, J E Adair, Kenneth B. Tomer, Thomas E. Eling, Tasuku Matsuoka, Kenneth Olden, Mark Rubino, Fred B. Lih, Masakazu Yashiro, Kousei Hirakawa
Publikováno v: British Journal of Cancer
Background: Dietary (n-6)-polyunsaturated fatty acids influence cancer development, but the mechanisms have not been well characterised in gastric carcinoma. Methods: We used two in vivo models to investigate the effects of these common dietary compo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5e0fe1184b2c06fdad651183b644c
https://doi.org/10.1038/sj.bjc.6605881
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2
15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor γ
Autor: Peiying Yang, L. C. Hsi, Jeri Kim, Gabriella Mendoza, Vemparala Subbarayan, David G. Menter, P. Krieg, Robert A. Newman, Scott M. Lippman, Anita L. Sabichi, Christopher J. Logothetis, Norma Llansa
Publikováno v: Oncogene. 25:6015-6025
An inverse relationship exists between the expression of 15-lipoxygenase-2 (15-LOX-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) in normal prostate epithelial cells (PrECs) compared with their expression in prostate carcinoma ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770f4a7eaea5029e77fb35ec130c4a16
https://doi.org/10.1038/sj.onc.1209617
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3
Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385
Autor: D C, Goodwin, M R, Gunther, L C, Hsi, B C, Crews, T E, Eling, R P, Mason, L J, Marnett
Publikováno v: The Journal of biological chemistry. 273(15)
Tyrosyl radicals have been detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they are speculated to participate in cyclooxygenase catalysis. Spectroscopic approaches to elucidate the identity of the radicals have not been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8712c8e004af27150353482606af1e0
https://pubmed.ncbi.nlm.nih.gov/9535872
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4
Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis
Autor: A, Tsai, L C, Hsi, R J, Kulmacz, G, Palmer, W L, Smith
Publikováno v: The Journal of biological chemistry. 269(7)
Several free radical species, attributed to tyrosyl radicals, have been previously observed by electron paramagnetic resonance (EPR) spectroscopy during reaction of pure ovine prostaglandin H synthase-1 (PGHS-1) with hydroperoxide or fatty acid subst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21486fec9abf1b3a317d9da84a402cfd
https://pubmed.ncbi.nlm.nih.gov/8106487
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5
Trp387 and the putative leucine zippers of PGH synthases-1 and -2
Autor: L C, Hsi, A L, Tsai, R J, Kulmacz, D G, English, A O, Siefker, J C, Otto, W L, Smith
Publikováno v: Journal of lipid mediators. 6(1-3)
The active site sequence 385-YHWH-388 of ovine prostaglandin endoperoxide synthase-1 (PGHS-1) has residues critical for cyclooxygenase and peroxidase catalysis. Tyr385 is essential for cyclooxygenase activity, His386, for peroxidase activity, and His
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a9dfef06aa66dabec377104caac5ad7
https://pubmed.ncbi.nlm.nih.gov/8357979
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