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Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2

Autor: Lei Han, Keqian Yang, L. C. Vining

Publikováno v: Journal of Bacteriology. 177:6111-6117

The nucleotide sequence of a region upstream of the type II polyketide synthase genes in the cluster for biosynthesis of the polyketide antibiotic jadomycin B in Streptomyces venezuelae contained an open reading frame encoding a sequence of 196 amino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e0da093d8e5e0260bdafbb43a3f026
https://doi.org/10.1128/jb.177.21.6111-6117.1995

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Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration

Autor: Z, Chang, L C, Vining

Publikováno v: Microbiology (Reading, England). 148(Pt 7)

A 0.5 kb fragment of Streptomyces venezuelae ISP5230 genomic DNA was amplified by PCR using primers based on consensus sequences of cysteine synthase isozyme A from bacteria. The deduced amino acid sequence of the PCR product resembled not only cyste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::270e9125bd72d4460bfd9c3541aebce2
https://pubmed.ncbi.nlm.nih.gov/12101301

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The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene

Autor: J, He, N, Magarvey, M, Piraee, L C, Vining

Publikováno v: Microbiology (Reading, England). 147(Pt 10)

Regions of the Streptomyces venezuelae ISP5230 chromosome flanking pabAB, an amino-deoxychorismate synthase gene needed for chloramphenicol (Cm) production, were examined for involvement in biosynthesis of the antibiotic. Three of four ORFs in the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3874cd00df694a4600ce8c829b8206bd
https://pubmed.ncbi.nlm.nih.gov/11577160

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The pdx genetic marker adjacent to the chloramphenicol biosynthesis gene cluster in Streptomyces venezuelae ISP5230: functional characterization

Autor: N, Magarvey, J, He, K A, Aidoo, L C, Vining

Publikováno v: Microbiology (Reading, England). 147(Pt 8)

The pdx-4 mutation in Streptomyces venezuelae ISP5230 confers a growth requirement for pyridoxal (pdx) and is a marker for the genetically mapped cluster of genes associated with chloramphenicol biosynthesis. A gene regulating salvage synthesis of vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37d4f0a6eda97810542e9f6f24528665
https://pubmed.ncbi.nlm.nih.gov/11495988

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An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230

Autor: L, Han, K, Yang, K, Kulowski, E, Wendt-Pienkowski, C R, Hutchinson, L C, Vining

Publikováno v: Microbiology (Reading, England). 146

Analysis of a region of chromosomal DNA lying between jadR1 and jadI in the gene cluster for jadomycin biosynthesis in Streptomyces venezuelae ISP5230 detected an ORF encoding 584 amino acids similar in sequence to the biotin carboxylase (BC) and bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90944967ebc9c640003f792c02246690
https://pubmed.ncbi.nlm.nih.gov/10784049

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Probing the substrate specificity of an enzyme catalyzing inactivation of streptogramin B antibiotics using LC-MS and LC-MS/MS

Autor: K P, Bateman, P, Thibault, K, Yang, R L, White, L C, Vining

Publikováno v: Journal of mass spectrometry : JMS. 32(10)

LC-MS and LC-MS/MS analyses indicated that an enzyme responsible for inactivating the antibiotic etamycin is specific for streptogramins and acts on both type B-I and B-II streptogramin subgroups. No enzymatic activity was detected for other cyclodep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4940631cae2bb68718284e249fdba936
https://pubmed.ncbi.nlm.nih.gov/9358629

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