Zobrazeno 1 - 10
of 11
pro vyhledávání: '"L C, Quattrochi"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(8)
We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction. HepG2 cells, stably integrated with reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51d65ec352a4b33a11074a0892273822
https://pubmed.ncbi.nlm.nih.gov/11454723
https://pubmed.ncbi.nlm.nih.gov/11454723
Autor:
L C, Quattrochi, P S, Guzelian
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
Among the human liver cytochrome P450s (P450s), a family of microsomal hemoproteins responsible for catalyzing the oxidative metabolism of clinically used drugs and environmental chemicals, attention has been focused on CYP3A, a form that is the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::446f85e4f97da882f6c0288a0824fccd
https://pubmed.ncbi.nlm.nih.gov/11302925
https://pubmed.ncbi.nlm.nih.gov/11302925
Publikováno v:
Molecular pharmacology. 50(1)
Interindividual variation in the spontaneous and in the glucocorticoid-or rifampicin-inducible expression of the CYP3A cytochromes P450, the dominant froms of this supergene family that catalyze the oxidation of numerous drugs and environmental chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1139db479abc9ce51eb5859eefe0ba0d
https://pubmed.ncbi.nlm.nih.gov/8700101
https://pubmed.ncbi.nlm.nih.gov/8700101
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 73(6)
Although it has been known for more than three decades that administration of lipophilic chemicals, including phenobarbital, produces liver hypertrophy, proliferation of smooth endoplasmic reticulum, and induction of liver microsomal enzymes such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b83b478a5cc63f7a388f8f009e825d8
https://pubmed.ncbi.nlm.nih.gov/8558843
https://pubmed.ncbi.nlm.nih.gov/8558843
Publikováno v:
The Journal of biological chemistry. 269(9)
The gene for cytochrome P4501A2 is constitutively expressed in the liver of vertebrates and shows induced expression when an organism is exposed to polycyclic aromatic hydrocarbons and halogenated hydrocarbons. To identify DNA elements regulating tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e3b522879b2eb16741d875a923a185c
https://pubmed.ncbi.nlm.nih.gov/8120057
https://pubmed.ncbi.nlm.nih.gov/8120057
Autor:
W, Tassaneeyakul, D J, Birkett, M E, Veronese, M E, McManus, R H, Tukey, L C, Quattrochi, H V, Gelboin, J O, Miners
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(1)
Kinetic and inhibitor studies using cDNA-expressed enzymes and human liver microsomes have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and inhibitor probes towards the two isoforms comprising this subfamily. Express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::682216fa9b3747ef6e4be8d8bc47d78d
https://pubmed.ncbi.nlm.nih.gov/8474022
https://pubmed.ncbi.nlm.nih.gov/8474022
Autor:
L C, Quattrochi, R H, Tukey
Publikováno v:
Molecular pharmacology. 43(4)
In the presence of halogenated and polycyclic aromatic hydrocarbons, the CYP1A1 gene is regulated through induction after ligand binding to the cytosolic Ah receptor (AhR). Ligand-dependent AhR activation leads to nuclear translocation and binding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a78b466f1c2c8515199f484e7e613cfb
https://pubmed.ncbi.nlm.nih.gov/8386305
https://pubmed.ncbi.nlm.nih.gov/8386305
Publikováno v:
Cancer research. 50(11)
The human P-450 CYP1A1 gene and a P450IA2 complementary DNA have been expressed in Cos-1 cells and the expressed proteins were assayed for their capacity to metabolize the carcinogens 2-acetylaminofluorene (AAF), benzo(a)pyrene, 2-amino-3-methylimida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ab1730989e174aafd1534323a57de0c
https://pubmed.ncbi.nlm.nih.gov/2334931
https://pubmed.ncbi.nlm.nih.gov/2334931
Autor:
M E, McManus, W M, Burgess, M E, Veronese, J S, Felton, M G, Knize, E G, Snyderwine, L C, Quattrochi, R H, Tukey
Publikováno v:
Progress in clinical and biological research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9088b75a9b6b7f01c9df75be178496cd
https://pubmed.ncbi.nlm.nih.gov/2392457
https://pubmed.ncbi.nlm.nih.gov/2392457
Autor:
L C, Quattrochi, R H, Tukey
Publikováno v:
Molecular pharmacology. 36(1)
The regulation of the human cytochrome Cyp1A2 gene by 3-methylcholanthrene was studied through the transfection of 5'-flanking sequences into human cells. The Cyp1A2 promoter sequence and 3700 bases 5' to the cap site were linked to the procaryotic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d04051661efed3ef738bce5da3b17bfb
https://pubmed.ncbi.nlm.nih.gov/2747632
https://pubmed.ncbi.nlm.nih.gov/2747632