Zobrazeno 1 - 10
of 117
pro vyhledávání: '"L C, Murrin"'
Autor:
H. K. Happe, L. C. Murrin
Publikováno v:
The Journal of Comparative Neurology. 351:94-103
A putative choline transporter (CHOT1) has been cloned from rat brain and is reported to express a high-affinity, sodium-dependent, hemicholinium-3-insensitive choline transporter in oocytes. A second transporter (OCCREATRA) cloned from rabbit brain
Autor:
L. C. Murrin, H. K. Happe
Publikováno v:
Journal of Neurochemistry. 60:1191-1201
High-affinity choline transport (HAChT), the rate-limiting and regulatory step in acetylcholine (ACh) synthesis, is selectively localized to cholinergic neurons. Hemicholinium-3 (HC3), a potent and selective inhibitor of HAChT, has been used as a spe
Autor:
H. K. Happe, L. C. Murrin
Publikováno v:
The Journal of Comparative Neurology. 321:591-611
The development of cholinergic terminals in rat brain has been quantitatively analyzed by [3H]hemicholinium-3 autoradiography. [3H]Hemicholinium-3 binds to high affinity choline transport sites, a specific marker for cholinergic neurons. In neonatal
Autor:
H. K. Happe, L. C. Murrin
Publikováno v:
Journal of Neurochemistry. 58:2053-2059
High-affinity choline transport sites specifically bind [3H]hemicholinium-3. Hemicholinium-3 binding sites are regulated by in vivo drug treatments in the same manner as these drugs alter acetylcholine release and high-affinity choline transport. The
Autoradiographic Localization of Dopaminergic and Noradrenergic Receptors in the Bovine Pineal Gland
Publikováno v:
Journal of Neurochemistry. 57:1796-1802
Dopamine and norepinephrine are involved in regulation of melatonin synthesis in the pineal gland. In bovine pineal gland, D1- and D2-dopaminergic and alpha 1-adrenergic receptors have been characterized pharmacologically in several laboratories, whi
Publikováno v:
Annals of the New York Academy of Sciences. 585:189-201
The hippocampus, a component of the limbic system, is a prominent subcortical structure, which not only contains high concentrations of zinc, but also exhibits regional variations in this essential element, with concentrations being highest in the hi
Publikováno v:
General Pharmacology: The Vascular System. 21:367-386
1. Neuroleptic drugs (antipsychotics) produce numerous side effects which include serious extrapyramidal symptoms consisting of akathisia, dystonia, neuroleptic malignant syndrome, parkinsonian reactions such as postural abnormality, tremor, akinesia
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
Mice with altered alpha(2)-adrenergic receptor genes have become important tools in elucidating the subtype-specific functions of the three alpha(2)-adrenergic receptor subtypes because of the lack of sufficiently subtype-selective pharmacological ag
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
During postnatal development, alpha-2 adrenergic receptors (A2AR) change in both density and distribution. In forebrain, receptor density increases about 4-fold over neonatal levels, reaching adult levels before postnatal day (P) 28, whereas in hindb
Autor:
H. K. Happe, R. Hao, P. Rojas, Ronald F. Pfeiffer, L. C. Murrin, Patrick L. Iversen, Manuchair Ebadi, D. R. Cerutis
Publikováno v:
Neurochemistry international. 27(1)
Many, but not all, zinc-containing neurons in the brain are a subclass of the glutamatergic neurons, and they are found predominantly in the telencephalon. These neurons store zinc in their presynaptic terminals and release it by a calcium-dependent