Zobrazeno 1 - 10
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pro vyhledávání: '"L C, Happerfield"'
Publikováno v:
The Journal of Pathology. 183:412-417
Insulin-like growth factors (IGFs) play an important role in normal cellular growth and development and have been implicated in the regulation of tumour growth. Two receptors are recognized, IGFR-1 and IGFR-2, of which one, IGFR-1, is a transmembrane
Publikováno v:
European Journal of Cancer. 33:1846-1850
c-erbB-3, A recently identified member of the type I tyrosine kinase receptor family, has been shown to be overexpressed in invasive ductal carcinoma of breast. In this study, expression of the c-erbB-3 protein was examined in 57 cases of pure ductal
Publikováno v:
Journal of Clinical Pathology. 50:669-673
AIM: To investigate the relation between angiogenesis and inflammation in invasive carcinoma of the breast. METHODS: Sections from 75 invasive carcinomas of the breast were stained using immunohistochemistry for von Willebrand factor, CD3, CD8, CD45R
Publikováno v:
The Journal of Pathology. 181:200-206
Several recent studies suggest that vascular density may be an independent prognostic indicator in invasive carcinoma of the breast. Increased vascularity has also been shown in ductal carcinoma in situ (DCIS). The prognostic significance of the infl
Publikováno v:
British Journal of Cancer
The significance of inflammation in carcinoma of the breast is controversial. Little attention has been paid to different patterns of inflammation or inflammation associated with different histological types of carcinoma. We have looked at the patter
Publikováno v:
Histopathology. 28:301-308
The relevant anti-tumour mechanisms of recombinant interleukin-2 (rIL-2) in vivo are unclear but an influx of T-lymphocytes and macrophages has been noted in regressing lesions. One of the dose limiting toxicities of rIL-2 is the development of a cap
Publikováno v:
The Journal of Pathology. 178:190-194
Laminated occlusive thrombus was induced in the rat inferior vena cava (IVC) by a distal stenosis and injection of thrombin. Immunocytochemistry was performed on serial cryostat sections of the thrombus for tissue plasminogen activator (tPA) and a va
Autor:
L C Happerfield, Pete Smith, Walter M Gregory, L.G. Bobrow, David Miles, R D Rubens, R. Gillibrand
Publikováno v:
British Journal of Cancer
Sialyl-Tn (STn) is a carcinoma-associated carbohydrate determinant expressed on cancer-associated mucins and has the structure NANA alpha(2-6)alpha GalNAc. Expression of STn in colon and ovarian cancer is associated with a poor prognosis independent
Autor:
Yataro Daigo, Carlos Caldas, Paul D.P. Pharoah, L.G. Bobrow, Elena Cattaneo, Grace Callagy, L C Happerfield
Publikováno v:
Diagnostic molecular pathology : the American journal of surgical pathology, part B. 12(1)
The histopathologic classification of breast cancer stratifies tumors based on tumor grade, stage, and type. Despite an overall correlation with survival, this classification is poorly predictive and tumors with identical grade and stage can have mar
Publikováno v:
The Journal of pathology. 183(4)
Insulin-like growth factors (IGFs) play an important role in normal cellular growth and development and have been implicated in the regulation of tumour growth. Two receptors are recognized, IGFR-1 and IGFR-2, of which one, IGFR-1, is a transmembrane