Zobrazeno 1 - 10
of 30
pro vyhledávání: '"L Bruins, Slot"'
Autor:
Adrian Newman-Tancredi, P. Heusler, L. Bruins Slot, M.B. Assié, Fc C. Colpaert, Bernard Vacher, Cristina Cosi, Emilie Lauressergues, Jean-Claude Martel, J. Buritova, Didier Cussac
Publikováno v:
British Journal of Pharmacology. 156:338-353
Background and purpose: Activation of post-synaptic 5-HT1A receptors may provide enhanced therapy against depression. We describe the signal transduction profile of F15599, a novel 5-HT1A receptor agonist. Experimental approach: F15599 was compared w
Autor:
Laurent Bardin, Francis Colpaert, Mark S. Kleven, Adrian Newman-Tancredi, L. Bruins Slot, Bernard Vacher, Agnès L. Auclair, Ronan Depoortère
Publikováno v:
British Journal of Pharmacology. 151:266-277
Background and purpose: The D2/D3 receptor antagonist, D4 receptor partial agonist, and high efficacy 5-HT1A receptor agonist F15063 was shown to be highly efficacious and potent in rodent models of activity against positive symptoms of schizophrenia
Autor:
J.C. Martel, Cristina Cosi, Christiane Palmier, M.B. Assié, Francis Colpaert, Bernard Vacher, Didier Cussac, L. Bruins Slot, Adrian Newman-Tancredi, Isabelle Rauly-Lestienne
Publikováno v:
British Journal of Pharmacology. 151:237-252
Background and purpose: Combining 5-HT1A receptor activation with dopamine D2/D3 receptor blockade should improve negative symptoms and cognitive deficits in schizophrenia. We describe the in vitro profile of F15063 (N-[(2,2-dimethyl-2,3-dihydro-benz
Autor:
Francis Colpaert, L. Bruins Slot
Publikováno v:
Behavioural Pharmacology. 14:167-171
We determined whether tolerance develops to a morphine-induced state of memory. Rats were injected with 5 mg/kg of morphine and trained to complete a FR-10 schedule of lever presses in daily sessions. The dose-response curve of morphine (1.25-40 mg/k
Publikováno v:
Pharmacology Biochemistry and Behavior. 72:943-951
For the analysis of pharmacotherapeutic regimens for chronic pain in animals, it is important to establish delivery methods in which analgesics can be administered continuously and at a constant rate for a prolonged period of time. This allows for th
Publikováno v:
Pain. 91:33-45
The study examined the validity of oral fentanyl self-administration (FSA) as a measure of the chronic nociceptive pain that develops in rats with adjuvant arthritis independently of acute noxious challenges. Arthritic rats self-administered more of
Autor:
A, Newman-Tancredi, M-B, Assié, J-C, Martel, C, Cosi, L Bruins, Slot, C, Palmier, I, Rauly-Lestienne, F, Colpaert, B, Vacher, D, Cussac
Publikováno v:
British journal of pharmacology. 151(2)
Combining 5-HT(1A) receptor activation with dopamine D(2)/D(3) receptor blockade should improve negative symptoms and cognitive deficits in schizophrenia. We describe the in vitro profile of F15063 (N-[(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)eth
Autor:
L Bruins-Slot, Philip Gorwood, Naïma Hanoun, Jean Adès, Michel Hamon, P Blot, M.C Mouren-Siméoni, Claudette Boni, A Kipman
Publikováno v:
European psychiatry : the journal of the Association of European Psychiatrists. 17(4)
SummaryThe A allele of the 5-HT2A gene (–1438A/G polymorphism) has been associated with anorexia nervosa in four studies, but not in three others. One possibility to explain such a discrepancy is that the A allele acts as a modifying rather than a
Publikováno v:
Behavioural pharmacology. 12(8)
Although it is recognized that retrieval may be state-dependent, only recently has a paradigm been identified that allows state-dependence in rats to be demonstrated reliably and at relevant doses of CNS agents. In humans, the effects of scopolamine